Frederik A. Verburg
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Author Swipe
View article: Pre-administration of caffeine anhydrous food supplement potentially improves suppression of physiologic myocardial [18F]FDG uptake: a feasibility study.
Pre-administration of caffeine anhydrous food supplement potentially improves suppression of physiologic myocardial [18F]FDG uptake: a feasibility study. Open
Background Positron emission tomography/Computed tomography (PET/CT) with [ 18 F]FDG has an increasingly relevant role in diagnosing and treatment management of myocardial inflammation and infection. A major confounding factor i…
View article: In medio stat virtus: towards an evidence rather than dogma based discussion on indicating post-operative I-131 therapy for differentiated thyroid carcinoma
In medio stat virtus: towards an evidence rather than dogma based discussion on indicating post-operative I-131 therapy for differentiated thyroid carcinoma Open
View article: Core Outcome Set of the Surgical Treatment of Differentiated Thyroid Carcinoma: International Consensus by Delphi Study
Core Outcome Set of the Surgical Treatment of Differentiated Thyroid Carcinoma: International Consensus by Delphi Study Open
Background: No international consensus exists on the selection and reporting of outcomes after differentiated thyroid cancer (DTC) surgery, hindering assessment of new treatments and guideline formation. Therefore, we aimed t…
View article: Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation
Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation Open
Background Patients with resistance to thyroid hormone β (RTHβ) show elevated thyroid hormone concentrations with non-suppressed thyroid-stimulating hormone (TSH) concentrations and large phenotypic variability. Triac therapy has been succ…
View article: [ <sup>18</sup> F]Tetrafluoroborate PET/CT for detecting differentiated thyroid cancer: phase-II study protocol
[ <sup>18</sup> F]Tetrafluoroborate PET/CT for detecting differentiated thyroid cancer: phase-II study protocol Open
This prospective, multicenter phase-2 clinical trial includes adult patients with DTC and pathologically confirmed cervical lymph node metastases scheduled for thyroidectomy and lymph node dissection (Group 1) and patients with recurrent o…
View article: Thyroid Arterial Embolization for the Management of Benign and Malignant Thyroid Disease: A Systematic Review
Thyroid Arterial Embolization for the Management of Benign and Malignant Thyroid Disease: A Systematic Review Open
This review presents an overview of the literature regarding safety and efficacy of TAE. The lack of robust data, significant risk of serious complications (including nontarget embolization and mortality), and absence of a standardized, sa…
View article: Predictive factors of radioiodine ablation success: results from a MEDIRAD prospective clinical study for thyroid cancer
Predictive factors of radioiodine ablation success: results from a MEDIRAD prospective clinical study for thyroid cancer Open
Objective Serum thyroglobulin measurements are used in the long-term management of patients with differentiated thyroid cancer following thyroidectomy and radioiodine therapy. The use of predictive biomarkers, such as post-operative stimul…
View article: 131I SPECT/CT provides prognostic information in patients with differentiated thyroid cancer
131I SPECT/CT provides prognostic information in patients with differentiated thyroid cancer Open
View article: First real-world clinical experience with [177Lu]Lu-PSMA-I&T in patients with metastatic castration-resistant prostate cancer beyond VISION and TheraP criteria
First real-world clinical experience with [177Lu]Lu-PSMA-I&T in patients with metastatic castration-resistant prostate cancer beyond VISION and TheraP criteria Open
View article: Cardiovascular disease and radiopharmaceutical therapies– an underestimated risk?
Cardiovascular disease and radiopharmaceutical therapies– an underestimated risk? Open
View article: The Definition of Recurrence of Differentiated Thyroid Cancer: A Systematic Review of the Literature
The Definition of Recurrence of Differentiated Thyroid Cancer: A Systematic Review of the Literature Open
Background: Recurrence is a key outcome to evaluate the treatment effect of differentiated thyroid carcinoma (DTC). However, no consistent definition of recurrence is available in current literature or international guideline…
View article: Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass
Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass Open
View article: Advances in the Development of Positron Emission Tomography Tracers for Improved Detection of Differentiated Thyroid Cancer
Advances in the Development of Positron Emission Tomography Tracers for Improved Detection of Differentiated Thyroid Cancer Open
Thyroid cancer poses a significant challenge in clinical management, necessitating precise diagnostic tools and treatment strategies for optimal patient outcomes. This review explores the evolving field of radiotracers in the diagnosis and…
View article: Potential of PSMA-targeting radioligand therapy for malignant primary and secondary brain tumours using super-selective intra-arterial administration: a single centre, open label, non-randomised prospective imaging study
Potential of PSMA-targeting radioligand therapy for malignant primary and secondary brain tumours using super-selective intra-arterial administration: a single centre, open label, non-randomised prospective imaging study Open
View article: [<sup>18</sup>F]FET PET/MRI: An Accurate Technique for Detection of Small Functional Pituitary Tumors
[<sup>18</sup>F]FET PET/MRI: An Accurate Technique for Detection of Small Functional Pituitary Tumors Open
Small functional pituitary tumors can cause severely disabling symptoms and early death. The gold standard diagnostic approach includes laboratory tests and MRI, with or without inferior petrosal sinus sampling (IPSS). In up to 40% of pati…
View article: Replacing Lu-177 with Tb-161 in DOTA-TATE and PSMA-617 therapy: potential dosimetric implications for activity selection
Replacing Lu-177 with Tb-161 in DOTA-TATE and PSMA-617 therapy: potential dosimetric implications for activity selection Open
Aim To explore the dosimetric effect of substituting Lu-177 with Tb-161 in targeted radionuclide therapy (TRT) using the registered tracers DOTA-TATE and PSMA-617. Methods Using established kinetic data for [ 177 Lu]Lu-DOTA-TATE and [ 177 …
View article: The EANM guideline on radioiodine therapy of benign thyroid disease
The EANM guideline on radioiodine therapy of benign thyroid disease Open
This document provides the new EANM guideline on radioiodine therapy of benign thyroid disease. Its aim is to guide nuclear medicine physicians, endocrinologists, and practitioners in the selection of patients for radioiodine therapy. Its …
View article: Tumor size and presence of metastases in differentiated thyroid cancer: comparing cohorts from two countries
Tumor size and presence of metastases in differentiated thyroid cancer: comparing cohorts from two countries Open
Objective Incidence of thyroid cancer varies widely, even across neighboring countries. Data on this phenomenon are largely lacking but are likely related to differences in health care systems. Therefore, we explored whether there are diff…
View article: Adjuvant Radioiodine for Intermediate-Risk Papillary Thyroid Cancer—To Treat or Not to Treat
Adjuvant Radioiodine for Intermediate-Risk Papillary Thyroid Cancer—To Treat or Not to Treat Open
View article: Long‐term predictive value of highly sensitive thyroglobulin measurement
Long‐term predictive value of highly sensitive thyroglobulin measurement Open
Objective To examine the predictive value of unremarkable nonstimulated highly sensitive thyroglobulin (hsTg) measurement with regard to the results of stimulated thyroglobulin (Tg) measurement, diagnostic whole‐body scintigraphy, recurren…
View article: To give or not to give? A critical appraisal of a clinical trial on radioiodine treatment
To give or not to give? A critical appraisal of a clinical trial on radioiodine treatment Open
View article: Evaluating the use of a two-step age-based cutoff for the UICC/AJCC TNM staging system in patients with papillary or follicular thyroid cancer
Evaluating the use of a two-step age-based cutoff for the UICC/AJCC TNM staging system in patients with papillary or follicular thyroid cancer Open
Background The joint Union International Contre le Cancer and American Joint Committee on Cancer (UICC/AJCC) Tumor, Node, Metastasis (TNM) staging system for differentiated thyroid cancer (DTC) involves a single age cutoff as a prognostic …
View article: Thyroglobulin and thyroglobulin antibodies: assay-dependent management consequences in patients with differentiated thyroid carcinoma
Thyroglobulin and thyroglobulin antibodies: assay-dependent management consequences in patients with differentiated thyroid carcinoma Open
Objectives International guidelines recommend fixed cut-off values for thyroglobulin (Tg). These cut-offs do not take potential assay differences into account. This study aimed to evaluate if different assays for Tg and Tg antibodies (TgAb…
View article: The EANM practice guidelines for parathyroid imaging
The EANM practice guidelines for parathyroid imaging Open
View article: Questions and Controversies in the Clinical Application of Tyrosine Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated Thyroid Carcinoma: Expert Perspectives
Questions and Controversies in the Clinical Application of Tyrosine Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated Thyroid Carcinoma: Expert Perspectives Open
Notwithstanding regulatory approval of lenvatinib and sorafenib to treat radioiodine-refractory differentiated thyroid carcinoma (RAI-R DTC), important questions and controversies persist regarding this use of these tyrosine kinase inhibit…
View article: The efficacy and short- and long-term side effects of radioactive iodine treatment in pediatric Graves’ disease: a systematic review
The efficacy and short- and long-term side effects of radioactive iodine treatment in pediatric Graves’ disease: a systematic review Open
View article: The Efficacy and Short- and Long-Term Side Effects of Radioactive Iodine Treatment in Pediatric Graves’ Disease: A Systematic Review
The Efficacy and Short- and Long-Term Side Effects of Radioactive Iodine Treatment in Pediatric Graves’ Disease: A Systematic Review Open
Background: Graves’s disease (GD) is the most common cause of hyperthyroidism. Maximal 30% of pediatric GD patients achieve remission with antithyroid drugs. The majority of patients therefore require definitive treatment. Bo…
View article: Clinical performance of calcitonin and procalcitonin Elecsys<sup>®</sup> immunoassays in patients with medullary thyroid carcinoma
Clinical performance of calcitonin and procalcitonin Elecsys<sup>®</sup> immunoassays in patients with medullary thyroid carcinoma Open
Objectives Medullary thyroid carcinoma (MTC) is caused by a malignant transformation in the parafollicular C-cells of the thyroid, where calcitonin (CT) is released. Nowadays, CT is the main tumor marker used in the diagnosis and follow-up…
View article: EANM position paper on article 56 of the Council Directive 2013/59/Euratom (basic safety standards) for nuclear medicine therapy
EANM position paper on article 56 of the Council Directive 2013/59/Euratom (basic safety standards) for nuclear medicine therapy Open