Frédérik Fournier
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View article: Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy
Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy Open
Tissue inflammation is often broadly associated with cellular damage, yet sterile inflammation also plays critical roles in beneficial tissue remodeling. In the central nervous system, this is observed through a predominantly innate immune…
View article: Corticosteroids prevent pathological angiogenesis yet compromise reparative vascular remodeling in the retina
Corticosteroids prevent pathological angiogenesis yet compromise reparative vascular remodeling in the retina Open
Tissue inflammation is often broadly associated with cellular damage, yet sterile inflammation also plays critical roles in beneficial tissue remodeling. In the central nervous system (CNS), this is observed through a predominantly innate …
View article: Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life
Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life Open
Pathological neovascularization in age-related macular degeneration (nvAMD) drives the principal cause of blindness in the elderly. While there is a robust genetic association between genes of innate immunity and AMD, genome-to-phenome rel…
View article: Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis
Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis Open
Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet underlying mechanisms remain ill-defined. Here, we show that t…
View article: Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity
Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity Open
View article: Inhibition of BCL-xL with the small molecule UBX1967 targets Col1a1-positive endothelial cells in ischemic retinopathy
Inhibition of BCL-xL with the small molecule UBX1967 targets Col1a1-positive endothelial cells in ischemic retinopathy Open
View article: Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation
Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation Open
View article: Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition Open
View article: Cylindrical type integrable classical systems in a magnetic field
Cylindrical type integrable classical systems in a magnetic field Open
We present all second order classical integrable systems of the cylindrical\ntype in a three dimensional Euclidean space $\\mathbb{E}_3$ with a nontrivial\nmagnetic field. The Hamiltonian and integrals of motion have the form\n $H =\\frac{…
View article: Neuropilin-1 Deficiency on Myeloid Cells Promotes a Pro-inflammatory Phenotype while Inhibiting Choroidal Neovascularization.
Neuropilin-1 Deficiency on Myeloid Cells Promotes a Pro-inflammatory Phenotype while Inhibiting Choroidal Neovascularization. Open