Frederik Gwinner
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View article: A highly versatile biopolymer‐based platform for the maturation of human pluripotent stem cell‐derived cardiomyocytes enables functional analysis in vitro and <scp>3D</scp> printing of heart patches
A highly versatile biopolymer‐based platform for the maturation of human pluripotent stem cell‐derived cardiomyocytes enables functional analysis in vitro and <span>3D</span> printing of heart patches Open
Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) represent a valuable tool for in vitro modeling of the cardiac niche and possess great potential in tissue engineering applications. However, conventional polystyrene‐based cell…
View article: Long-term monitoring of mercury in young German adults: Time trend analyses from the German Environmental Specimen Bank, 1995–2018
Long-term monitoring of mercury in young German adults: Time trend analyses from the German Environmental Specimen Bank, 1995–2018 Open
As highlighted in the Minamata Convention, Mercury (Hg) in its various forms poses a substantial risk to human health and the environment. The health relevance of Hg is also recognized by the European Human Biomonitoring Initiative (HBM4EU…
View article: Sea Bass Primary Cultures versus RTgill-W1 Cell Line: Influence of Cell Model on the Sensitivity to Nanoparticles
Sea Bass Primary Cultures versus RTgill-W1 Cell Line: Influence of Cell Model on the Sensitivity to Nanoparticles Open
Determination of acute toxicity to vertebrates in aquatic environments is mainly performed following OECD test guideline 203, requiring the use of a large number of fish and with mortality as endpoint. This test is also used to determine t…
View article: Pitfalls in HLA Ligandomics—How to Catch a Li(e)gand
Pitfalls in HLA Ligandomics—How to Catch a Li(e)gand Open
Knowledge about the peptide repertoire presented by human leukocyte antigens (HLA) holds the key to unlock target-specific cancer immunotherapies such as adoptive cell therapies or bispecific T cell engaging receptors. Therefore, comprehen…
View article: Long-term time trend of lead exposure in young German adults – Evaluation of more than 35 Years of data of the German Environmental Specimen Bank
Long-term time trend of lead exposure in young German adults – Evaluation of more than 35 Years of data of the German Environmental Specimen Bank Open
Lead is a ubiquitous pollutant with well-known effects on human health. As there is no lower toxicological threshold for lead in blood and since data gaps on lead exposure still exist in many European countries, HBM data on lead is of high…
View article: Towards Harmonized Biobanking for Biomonitoring: A Comparison of Human Biomonitoring-Related and Clinical Biorepositories
Towards Harmonized Biobanking for Biomonitoring: A Comparison of Human Biomonitoring-Related and Clinical Biorepositories Open
Human biomonitoring (HBM) depends on high-quality human samples to identify status and trends in exposure and ensure comparability of results. In this context, much effort has been put into the development of standardized processes and qua…
View article: Trends in characteristics of 24-h urine samples and their relevance for human biomonitoring studies – 20 years of experience in the German Environmental Specimen Bank
Trends in characteristics of 24-h urine samples and their relevance for human biomonitoring studies – 20 years of experience in the German Environmental Specimen Bank Open
View article: Network-based analysis of omics data: the LEAN method
Network-based analysis of omics data: the LEAN method Open
Motivation Most computational approaches for the analysis of omics data in the context of interaction networks have very long running times, provide single or partial, often heuristic, solutions and/or contain user-tuneable parameters. Res…
View article: Bacterial Internalization, Localization, and Effectors Shape the Epithelial Immune Response during Shigella flexneri Infection
Bacterial Internalization, Localization, and Effectors Shape the Epithelial Immune Response during Shigella flexneri Infection Open
Intracellular pathogens are differentially sensed by the compartmentalized host immune system. Nevertheless, gene expression studies of infected cells commonly average the immune responses, neglecting the precise pathogen localization. To …
View article: Identification and characterization of an <scp>ABA</scp>‐activated <scp>MAP</scp> kinase cascade in <i>Arabidopsis thaliana</i>
Identification and characterization of an <span>ABA</span>‐activated <span>MAP</span> kinase cascade in <i>Arabidopsis thaliana</i> Open
Summary Abscisic acid ( ABA ) is a major phytohormone involved in important stress‐related and developmental plant processes. Recent phosphoproteomic analyses revealed a large set of ABA ‐triggered phosphoproteins as putative mitogen‐activ…