Frederik J. Verweij
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View article: Beyond the Secretory Pathway: New Insights Into Protein Release
Beyond the Secretory Pathway: New Insights Into Protein Release Open
In eukaryotes, protein secretion plays essential roles in intercellular communications and extracellular niche‐building. Protein secretion generally requires a signal sequence that targets cargos to the canonical secretory pathway consisti…
View article: Author response: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Author response: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
View article: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs
HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs Open
Amyloid precursor protein (APP) is a key player in various neuronal functions but also the source for toxic Aβ that accumulates in the brain of Alzheimer patients. APP trafficking and processing depend on the endo-lysosomal system, but the…
View article: Beyond the Secretory Pathway: New Insights into Protein Release
Beyond the Secretory Pathway: New Insights into Protein Release Open
View article: Author response: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Author response: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
View article: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion
CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion Open
Extracellular vesicles (EVs) are crucial mediators of intercellular communication that originate through one of two pathways: outward budding of the plasma membrane (PM) or fusion of mature (late) endosomes with the PM. How cells balance t…
View article: Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes
Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes Open
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyo…
View article: ExoJ – a Fiji/ImageJ2 plugin for automated spatiotemporal detection and analysis of exocytosis
ExoJ – a Fiji/ImageJ2 plugin for automated spatiotemporal detection and analysis of exocytosis Open
Exocytosis is a dynamic physiological process that enables the release of biomolecules to the surrounding environment via the fusion of membrane compartments to the plasma membrane. Understanding its mechanisms is crucial, as defects can c…
View article: CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes Open
View article: Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes
Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes Open
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyo…
View article: Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Reviewer #2 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Reviewer #2 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Reviewer #1 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI
Reviewer #1 (Public Review): Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI
Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI Open
The extracellular matrix (ECM) supports blood vessel architecture and functionality and undergoes active remodelling during vascular repair and atherogenesis. Vascular smooth muscle cells (VSMCs) are essential for vessel repair and, via th…
View article: Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging Open
View article: Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition
Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition Open
Dysregulated extracellular vesicle (EV) release has been implicated in various pathologies, including cancer, neurodegenerative disease and osteoarthritis. Despite clear therapeutic potential, drug screening for EV release modulators has y…
View article: CD63 regulates cholesterol storage within endosomes and its distribution via exosomes
CD63 regulates cholesterol storage within endosomes and its distribution via exosomes Open
Exosomes are small extracellular vesicles that are enriched in specific proteins and lipids during their generation as intraluminal vesicles in multivesicular endosomes. Contrary to proteins, the endosomal sorting mechanisms of lipids on i…
View article: ER membrane contact sites support endosomal small GTPase conversion for exosome secretion
ER membrane contact sites support endosomal small GTPase conversion for exosome secretion Open
Exosomes are endosome-derived extracellular vesicles involved in intercellular communication. They are generated as intraluminal vesicles within endosomal compartments that fuse with the plasma membrane (PM). The molecular events that gene…
View article: ExoJ: an ImageJ2/Fiji plugin for automated spatiotemporal detection and analysis of exocytosis
ExoJ: an ImageJ2/Fiji plugin for automated spatiotemporal detection and analysis of exocytosis Open
Exocytosis is a dynamic physiological process that enables the release of biomolecules to the surrounding environment via the fusion of membrane compartments to the plasma membrane. Understanding its mechanisms is crucial, as defects can c…
View article: The power of imaging to understand extracellular vesicle biology in vivo
The power of imaging to understand extracellular vesicle biology in vivo Open
View article: In vivo imaging of EVs in zebrafish: New perspectives from “the waterside”
In vivo imaging of EVs in zebrafish: New perspectives from “the waterside” Open
To harmoniously coordinate the activities of all its different cell types, a multicellular organism critically depends on intercellular communication. One recently discovered mode of intercellular cross‐talk is based on the exchange of "ex…
View article: Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9
Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9 Open
View article: Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking and synchronized extracellular vesicle release of CD9 and CD63
Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking and synchronized extracellular vesicle release of CD9 and CD63 Open
Despite their important and multiple roles in intercellular communications, the different populations of extracellular vesicles (EVs) and their secretion mechanisms are not fully characterized yet. In particular, how and to what extent EVs…
View article: Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
Origin and role of the cerebrospinal fluid bidirectional flow in the central canal Open
Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain development. Here, we investigated the unexplained origins of the CSF flow bidirectionality in the central canal of the spinal cord of 30 hpf zebrafi…
View article: Meeting Abstracts of the American Society for Exosomes and Microvesicles 2020 Annual Meeting
Meeting Abstracts of the American Society for Exosomes and Microvesicles 2020 Annual Meeting Open
Extracellular Vesicles and Circulating Nucleic Acids is an open access journal, focusing on extracellular vesicles and circulating nucleic acids including DNA, RNA, and miRNA and their therapeutic use.
View article: Real-time imaging of multivesicular body–plasma membrane fusion to quantify exosome release from single cells
Real-time imaging of multivesicular body–plasma membrane fusion to quantify exosome release from single cells Open
View article: Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop Open
Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer membranes. To ev…