Frederik Nevens
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View article: Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis
Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis Open
Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis. However, the clinical relevance and how discordant biochemical and LSM changes should be best interp…
View article: EFFICACY AND SAFETY OF SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND COMPENSATED CIRRHOSIS IN THE PHASE 3 PLACEBO-CONTROLLED RESPONSE TRIAL
EFFICACY AND SAFETY OF SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND COMPENSATED CIRRHOSIS IN THE PHASE 3 PLACEBO-CONTROLLED RESPONSE TRIAL Open
Introduction and Objectives: In the Phase 3 RESPONSE trial (NCT04620733), seladelpar, a first-in-class delpar (selective peroxisome proliferator–activated receptor delta agonist), significantly improved biomarkers of cholestasis in patient…
View article: 532: EFFICACY AND SAFETY OF SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND COMPENSATED CIRRHOSIS IN THE PHASE 3 PLACEBO-CONTROLLED RESPONSE TRIAL
532: EFFICACY AND SAFETY OF SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND COMPENSATED CIRRHOSIS IN THE PHASE 3 PLACEBO-CONTROLLED RESPONSE TRIAL Open
View article: Phosphatidylethanol and ethyl glucuronide to categorize alcohol consumption in alcohol-related cirrhosis
Phosphatidylethanol and ethyl glucuronide to categorize alcohol consumption in alcohol-related cirrhosis Open
View article: Development of a Question Prompt List for People Living With Primary Biliary Cholangitis: A Delphi Study
Development of a Question Prompt List for People Living With Primary Biliary Cholangitis: A Delphi Study Open
The PBC patient question prompt list serves as a user-facing document, to enhance the patient experience, and drive value-based healthcare in routine clinical practice.
View article: The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT
The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT Open
Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejec…
View article: Fibrate-Oca (FI-OCA) Study - a Global snapshot of PBC practice around the Globe
Fibrate-Oca (FI-OCA) Study - a Global snapshot of PBC practice around the Globe Open
View article: Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression
Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression Open
View article: Risk factors for SARS-CoV-2 infection and severe COVID-19 in unvaccinated solid organ transplant recipients
Risk factors for SARS-CoV-2 infection and severe COVID-19 in unvaccinated solid organ transplant recipients Open
View article: Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome
Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome Open
View article: Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis
Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis Open
View article: Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis
Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis Open
View article: Clinical management of liver cyst infections: an international, modified Delphi-based clinical decision framework
Clinical management of liver cyst infections: an international, modified Delphi-based clinical decision framework Open
View article: Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation
Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation Open
View article: Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure
Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure Open
Background and Aims: Acute-on-chronic liver failure (ACLF) is a complication of cirrhosis characterized by multiple organ failure and high short-term mortality. The pathophysiology of ACLF involves elevated systemic inflammation leading to…
View article: Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis
Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis Open
Plasma NfL deserves further evaluation as potential diagnostic biomarker for oHE and correlates with the MELD score.
View article: Tacrolimus Drug Exposure Level and Smoking Are Modifiable Risk Factors for Early De Novo Malignancy After Liver Transplantation for Alcohol-Related Liver Disease
Tacrolimus Drug Exposure Level and Smoking Are Modifiable Risk Factors for Early De Novo Malignancy After Liver Transplantation for Alcohol-Related Liver Disease Open
De novo malignancy (DNM) is the primary cause of mortality after liver transplantation (LT) for alcohol-related liver disease (ALD). However, data on risk factors for DNM development after LT are limited, specifically in patients with ALD.…
View article: Histological characteristics in patients admitted to the hospital with alcoholic hepatitis complicated by acute-on-chronic liver failure
Histological characteristics in patients admitted to the hospital with alcoholic hepatitis complicated by acute-on-chronic liver failure Open
In this well-defined cohort of patients with biopsy-proven AH, DB was associated with the presence of ACLF. This finding fits with the pathophysiology of this syndrome, which is characterized by systemic inflammation and an increased risk …
View article: Contemporary and historical human migration patterns shape hepatitis B virus diversity
Contemporary and historical human migration patterns shape hepatitis B virus diversity Open
Infection by hepatitis B virus (HBV) is responsible for approximately 296 million chronic cases of hepatitis B, and roughly 880,000 deaths annually. The global burden of HBV is distributed unevenly, largely owing to the heterogeneous geogr…
View article: SARS-CoV-2 anti-spike IgG antibodies are present in all liver transplant recipients after fifth vaccine dose
SARS-CoV-2 anti-spike IgG antibodies are present in all liver transplant recipients after fifth vaccine dose Open
View article: Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease
Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease Open
View article: Phylogenetic Analysis of Hepatitis C Virus Infections in a Large Belgian Cohort Using Next-Generation Sequencing of Full-Length Genomes
Phylogenetic Analysis of Hepatitis C Virus Infections in a Large Belgian Cohort Using Next-Generation Sequencing of Full-Length Genomes Open
The hepatitis C virus (HCV) epidemic in Western countries is primarily perpetuated by the sub-populations of men who have sex with men (MSM) and people who inject drugs (PWID). Understanding the dynamics of transmission in these communitie…
View article: Outcomes of liver transplantation for hepatopulmonary syndrome in patients with concomitant respiratory disease
Outcomes of liver transplantation for hepatopulmonary syndrome in patients with concomitant respiratory disease Open
Background & aims Concomitant respiratory disease is a common finding in patients with hepatopulmonary syndrome (HPS). Among patients who underwent liver transplantation (LT) for HPS, we compared characteristics and outcome of patients wit…
View article: Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding
Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding Open
View article: Higher need for polycystic liver disease therapy in female patients: Sex-specific association between liver volume and need for therapy
Higher need for polycystic liver disease therapy in female patients: Sex-specific association between liver volume and need for therapy Open
Background and Aims: Prognostic tools or biomarkers are urgently needed in polycystic liver disease (PLD) to monitor disease progression and evaluate treatment outcomes. Total liver volume (TLV) is currently used to assess cross-sectional …
View article: Corrigendum to “EASL clinical practice guidelines on the management of cystic liver diseases” [J Hepatol (77) 1083–1108]
Corrigendum to “EASL clinical practice guidelines on the management of cystic liver diseases” [J Hepatol (77) 1083–1108] Open
View article: Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ)
Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ) Open
View article: Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?
Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain? Open
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated with better long-term outcome. However, second-line therapies are currently…
View article: Questionnaire PLD‐complaint‐specific assessment identifies need for therapy in polycystic liver disease: A multi‐centric prospective study
Questionnaire PLD‐complaint‐specific assessment identifies need for therapy in polycystic liver disease: A multi‐centric prospective study Open
Background and Aims Polycystic liver disease (PLD) can lead to extensive hepatomegaly. Symptom relief is the primary goal of the treatment. The role of the recently developed disease‐specific questionnaires for identification of the thresh…
View article: Setanaxib, a first‐in‐class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo‐controlled, phase 2 trial
Setanaxib, a first‐in‐class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo‐controlled, phase 2 trial Open
Background Primary biliary cholangitis (PBC) is a rare liver disease with significant unmet need for second‐line/add‐on treatments. Setanaxib, a NOX1/4 inhibitor, has shown anti‐fibrotic effects in in vitro and animal studies. This phase 2…