Frederike T. Fellendorf
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View article: The Role of Sex in Clinical Characteristics and Pharmacological Treatment of Bipolar Disorder
The Role of Sex in Clinical Characteristics and Pharmacological Treatment of Bipolar Disorder Open
Introduction: There has been an increasing focus on sex differences in bipolar disorder in recent years, yet much remains to be understood about their impact on clinical characteristics and treatment approaches. The aim of this study was t…
View article: Fine-mapping genomic loci refines bipolar disorder risk genes
Fine-mapping genomic loci refines bipolar disorder risk genes Open
View article: Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity
Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity Open
Importance The clinical heterogeneity of bipolar disorder (BD) is a major obstacle to improving diagnosis, predicting patient outcomes, and developing personalized treatments. A genetic approach is needed to deconstruct the disorder and un…
View article: Cognitive abilities and psychosocial functioning in bipolar disorder: findings from the BIPLONG study
Cognitive abilities and psychosocial functioning in bipolar disorder: findings from the BIPLONG study Open
Background Bipolar disorder is associated with impairments in cognition and psychosocial functioning. Although these impairments occur frequently, often persist during euthymic times, and worsen quality of life, the impact of cognitive abi…
View article: Social robots in adult psychiatry: a summary of utilisation and impact
Social robots in adult psychiatry: a summary of utilisation and impact Open
Social robots are increasingly becoming more prevalent in healthcare, including nursing, geriatric care, and treatment for children on the autism spectrum. Their assistance is believed to hold promise in mitigating the effects of staffing …
View article: Genomics yields biological and phenotypic insights into bipolar disorder
Genomics yields biological and phenotypic insights into bipolar disorder Open
Bipolar disorder is a leading contributor to the global burden of disease1. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown2. We analysed data from participants o…
View article: Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review
Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review Open
Background: Bipolar disorder (BD) is a psychiatric condition with significant health implications due to its comorbidities, premature mortality, and functional impairments. Despite extensive research on treatment and rehabilitation, gaps r…
View article: Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder
Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder Open
View article: Cognitive Function in Individuals with Chronic Hypoparathyroidism—A Prospective Observational Study
Cognitive Function in Individuals with Chronic Hypoparathyroidism—A Prospective Observational Study Open
Objective “Brain fog” is a frequently reported, distressing experience among individuals with chronic hypoparathyroidism, characterized by reduced concentration and reduced ability to perform day-to-day tasks. However, evidence linking chr…
View article: Toxoplasma gondii IgG serointensity and cognitive function in bipolar disorder
Toxoplasma gondii IgG serointensity and cognitive function in bipolar disorder Open
View article: Better understanding of c-reactive protein and leukocytes in psychiatric inpatients with affective disorders: A biopsychosocial approach
Better understanding of c-reactive protein and leukocytes in psychiatric inpatients with affective disorders: A biopsychosocial approach Open
BACKGROUND Affective disorders (AD) have been linked to inflammatory processes, although the underlying mechanisms of this relationship are still not fully elucidated. It is hypothesized that demographic, somatic, lifestyle, and personalit…
View article: Toxoplasma gondii IgG Serointensity and Cognitive Function in Bipolar Disorder
Toxoplasma gondii IgG Serointensity and Cognitive Function in Bipolar Disorder Open
Background Alongside affective episodes, cognitive dysfunction is a core symptom of bipolar disorder. The intracellular parasite Toxoplasma gondii has been positively associated with both a diagnosis of bipolar disorder as well as poorer c…
View article: Theory of mind abilities during the course of bipolar disorder: A longitudinal study using mixed models
Theory of mind abilities during the course of bipolar disorder: A longitudinal study using mixed models Open
Theory of mind (ToM) deficits, difficulties in recognizing the intentions, propensities, and beliefs of others have been shown in individuals with bipolar disorder in several studies; however, it is not yet elucidated how ToM abilities cha…
View article: Changes in tryptophan breakdown associated with response to multimodal treatment in depression
Changes in tryptophan breakdown associated with response to multimodal treatment in depression Open
Background Research on depression showed that dysregulations in tryptophan (TRP), kynurenine (KYN), and its KYN pathway metabolites are key aspects in the development and maintenance of depressive symptoms. In our previous reports, we desc…
View article: PROVIT-CLOCK: A Potential Influence of Probiotics and Vitamin B7 Add-On Treatment and Metabolites on Clock Gene Expression in Major Depression
PROVIT-CLOCK: A Potential Influence of Probiotics and Vitamin B7 Add-On Treatment and Metabolites on Clock Gene Expression in Major Depression Open
Introduction: An increasing body of evidence suggests a strong relationship between gut health and mental state. Lately, a connection between butyrate-producing bacteria and sleep quality has been discussed. The PROVIT study, as a randomiz…
View article: The influence of chronic inflammation on the illnesscourse of bipolar disorder: A longitudinal study
The influence of chronic inflammation on the illnesscourse of bipolar disorder: A longitudinal study Open
Individuals who were exposed to a higher level of inflammation over time suffered from more manic symptoms in this period. These findings underline the hypothesis that inflammatory processes have an accumulative influence on the illness co…
View article: Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study Open
View article: Fine-mapping genomic loci refines bipolar disorder risk genes
Fine-mapping genomic loci refines bipolar disorder risk genes Open
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite…
View article: Serum neurofilament light as a potential marker of illness duration in bipolar disorder
Serum neurofilament light as a potential marker of illness duration in bipolar disorder Open
Interestingly, individuals with BD and HC did not differ in sNFL levels in general. Nevertheless, looking at the BD cohort more specifically, we found that individuals with BD with longer duration of illness (>3 years) had higher levels of…
View article: Extended reality training to enhance resilience in healthcare workers: Preliminary findings from XRes4HEALTH
Extended reality training to enhance resilience in healthcare workers: Preliminary findings from XRes4HEALTH Open
View article: Cognitive introspective accuracy: self-assessment of cognitive abilities of patients with unipolar depression
Cognitive introspective accuracy: self-assessment of cognitive abilities of patients with unipolar depression Open
View article: Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice
Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice Open
Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes of depression and (hypo-) mania. The gut microbiome is a potential avenue through which metabolic signaling, inflammatory pathways, environmental factors,…
View article: Vitamin D Status in Bipolar Disorder
Vitamin D Status in Bipolar Disorder Open
Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2D, and the vitamin D metabolite ratio (VMR) i…
View article: Impaired implicit learning in adults with anorexia nervosa
Impaired implicit learning in adults with anorexia nervosa Open
Objective Cognitive alterations play an important role in the pathophysiology and treatment of anorexia nervosa (AN). Previous studies suggest that some implicit learning processes may be inhibited in AN. However, this has not yet been ful…
View article: Genomics yields biological and phenotypic insights into bipolar disorder
Genomics yields biological and phenotypic insights into bipolar disorder Open
Bipolar disorder (BD) is a leading contributor to the global burden of disease 1 . Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown 2 . We analysed data from participants of European, E…
View article: Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study Open
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bi…
View article: Vitamin D status in Bipolar Disorder
Vitamin D status in Bipolar Disorder Open
Vitamin D status may impact acute affective symptomatology and the severity of symptoms in patients with bipolar disorder (BD). Therefore, this cross-sectional study analyzed 25(OH)D, 24,25(OH)2D, and the vitamin D metabolite ratio (VMR) i…
View article: The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls
The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls Open
Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet…
View article: Impact of the COVID-19 Pandemic on Productivity of Workers in the Health Sector between Working in a Hospital and from Home
Impact of the COVID-19 Pandemic on Productivity of Workers in the Health Sector between Working in a Hospital and from Home Open
Background: Due to the COVID-19 pandemic, workplaces in the medical field experienced changes. Non-frontline workers in the health sector (WHS) were in many cases allowed to work from home (WFH). Changes in work locations have affected the…
View article: Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder Open