Frederike Westermann
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View article: Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology
Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology Open
Regulatory T (Treg) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. Treg cell depletion or dysfunction results in fatal multiorgan inflammation linked to unrestrained effector T ce…
View article: GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to <i>Aspergillus fumigatus</i>
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to <i>Aspergillus fumigatus</i> Open
Aspergillus fumigatus causes life-threatening mold pneumonia in immunocompromised patients, particularly in those with quantitative or qualitative defects in neutrophils. Whereas innate immune cell cross-talk licenses neutrophil antifungal…
View article: Tissue imprinting defines functional mosaic of dermal macrophages
Tissue imprinting defines functional mosaic of dermal macrophages Open
Dermal macrophages (macs) protect the skin from invading pathogens. They are derived from embryonic as well as hematopoietic progenitors. However, the functional impact of their diverse origin and the control networks defining different su…
View article: Tumor Surface Signature Distinguishes IDH Mutant from Wildtype High Grade Glioma and Identifies Novel Targets for Immunotherapy
Tumor Surface Signature Distinguishes IDH Mutant from Wildtype High Grade Glioma and Identifies Novel Targets for Immunotherapy Open
View article: Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells Open
Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues durin…
View article: Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF
Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF Open
Summary Granulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in the emergence and maintenance of alveolar macrophages (AMs). However, its role in developmental and steady-state myelopoiesis outside the lung is…
View article: Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells
Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells Open
SUMMARY Regulatory T (T reg ) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. T reg cell depletion or dysfunction rapidly results in fatal multiorgan inflammation linked to unrestrained effector T cell …
View article: GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to<i>Aspergillus fumigatus</i>
GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to<i>Aspergillus fumigatus</i> Open
SUMMARY Aspergillus fumigatus causes life-threatening mold pneumonia in immune compromised patients, particularly in those with quantitative or qualitative defects in neutrophils. While innate immune cell crosstalk licenses neutrophil anti…