Explanipedia

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Prateek Sharma, Michael F. Vaezi, Peter Unge, Kjell Andersson, Kajsa Larsson , et al. · 2025

Clinical Trial: Dose‐Finding Study of Linaprazan Glurate, A Novel Potassium‐Competitive Acid Blocker, Versus Lansoprazole for the Treatment of Erosive Oesophagitis Open

Prateek Sharma, Michael F. Vaezi, Peter Unge, Kjell Andersson, Kajsa Larsson , et al. · 2025

Background Linaprazan glurate, a potassium‐competitive acid blocker, is in development for the treatment of erosive oesophagitis and other acid‐related diseases. Aim To evaluate the 4‐week healing rate and safety of four linaprazan glurate…

Management of Patients With Refractory Reflux‐Like Symptoms Despite Proton Pump Inhibitor Therapy: Evidence‐Based Consensus Statements Open

David Armstrong, A. P. S. Hungin, Peter J. Kahrilas, Daniel Sifrim, Paul Moayyedi , et al. · 2024

Background Many patients diagnosed with gastro‐oesophageal reflux disease (GERD) have persistent symptoms despite proton pump inhibitor (PPI) therapy. Aims The aim of this consensus is to provide evidence‐based statements to guide clinicia…

Vasoactive Intestinal Peptide Receptor, CRTH2, Antagonist Treatment Improves Eosinophil and Mast Cell-Mediated Esophageal Remodeling and Motility Dysfunction in Eosinophilic Esophagitis Open

Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Alok Kumar Verma, Chandrasekhar Kathera, Pearce S. Duncan , et al. · 2024

Background and Aims: Ultrasonography has shown that eosinophils accumulate in each segment of the esophageal mucosa in human EoE, ultimately promoting esophageal motility dysfunction; however, no mechanistic evidence explains how or why th…

The Dubai Definition and Diagnostic Criteria of Laryngopharyngeal Reflux: The <span>IFOS</span> Consensus Open

Jérôme R. Lechien, Michael F. Vaezi, Walter W. Chan, Jacqueline Allen, Petros D. Karkos , et al. · 2023

Objective The objective of this work was to gather an international consensus group to propose a global definition and diagnostic approach of laryngopharyngeal reflux (LPR) to guide primary care and specialist physicians in the management …

A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome Open

Justin Jacobse, Rachel E. Brown, Frank Revetta, Michael F. Vaezi, Matthew A. Buendia , et al. · 2023

Randomised clinical trial: Efficacy and safety of <span>on‐demand</span> vonoprazan versus placebo for non‐erosive reflux disease Open

Ronnie Fass, Michael F. Vaezi, Prateek Sharma, Rena Yadlapati, Barbara Hunt , et al. · 2023

Summary Background Non‐erosive reflux disease (NERD) symptoms are often episodic, making on‐demand treatment an attractive treatment approach. Aims We compared the efficacy and safety of on‐demand vonoprazan versus placebo in patients with…

Updates to the modern diagnosis of GERD: Lyon consensus 2.0 Open

C. Prakash Gyawali, Rena Yadlapati, Ronnie Fass, David A. Katzka, John E. Pandolfino , et al. · 2023

The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusiv…

E-014 Stent-assisted coiling for treatment of acutely ruptured cerebral aneurysm Open

Humain Baharvahdat, Farid Qoorchi Moheb Seraj, Michael F. Vaezi, Feizollah Ebrahimnia, R. Gorji , et al. · 2023

Introduction Stent-assisted coiling (SAC) has been developed and used as high effective treatment of wide-neck cerebral aneurysms. Yet, it's safety is controversial in management of ruptured cerebral aneurysms in acute phase of subarachnoi…

Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study Open

Peter V. Dicpinigaitis, Alyn H. Morice, John A. Smith, Mandel Sher, Michael F. Vaezi , et al. · 2023

Should POEM Be the Rescue Therapy of Choice After Failed Laparoscopic Heller Myotomy? Open

Marcelo F. Vela, Michael F. Vaezi · 2023

Inter‐ and intra‐rater agreement of interpretation of functional lumen imaging probe in healthy subjects Open

Rena Yadlapati, C. Prakash Gyawali, Dustin A. Carlson, John E. Pandolfino, Ronnie Fass , et al. · 2022

Background The functional lumen imaging probe (FLIP) evaluates esophagogastric junction (EGJ) opening and esophageal contractility. Both post hoc and real‐time analyses are possible, but reproducibility and reliability of analysis remain u…

Validation of the Achalasia Patient‐Reported Outcomes Questionnaire Open

John E. Pandolfino, Dustin A. Carlson, Josie McGarva, Peter J. Kahrilas, Michael F. Vaezi , et al. · 2022

Summary Background Achalasia is a debilitating major motor disorder of the oesophagus. Hypervigilance and symptom‐specific anxiety substantially impact dysphagia symptom reporting, and quality of life is a critical patient outcome. Earlier…

Clinical role of ambulatory reflux monitoring in PPI non‐responders: recommendation statements Open

Rena Yadlapati, Andrew J. Gawron, C. Prakash Gyawali, Joan W. Chen, John O. Clarke , et al. · 2022

Summary Background Optimal ambulatory reflux monitoring methodology in symptomatic reflux patients continues to be debated. Aims To utilise published literature and expert opinion to develop recommendation statements addressing use of ambu…

Patient journey in erosive oesophagitis: real-world perspectives from US physicians and patients Open

Michael F. Vaezi, Stephen Brunton, A. Mark Fendrick, Colin W. Howden, Christian Atkinson , et al. · 2022

Objective Management of erosive oesophagitis (EE) remains suboptimal, with many patients experiencing incomplete healing, ongoing symptoms, and relapse despite proton pump inhibitor (PPI) treatment. The Study of Acid-Related Disorders inve…

The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial Open

Cihang Gu, Timothy Olszewski, Karen L. King, Michael F. Vaezi, Kevin D. Niswender , et al. · 2022

INTRODUCTION: This is the first randomized controlled diet intervention trial to investigate both the amount and type of carbohydrate on symptomatic gastroesophageal reflux disease (GERD). METHODS: Ninety-eight veterans with symptomatic GE…

Optimal Wireless Reflux Monitoring Metrics to Predict Discontinuation of Proton Pump Inhibitor Therapy Open

Rena Yadlapati, C. Prakash Gyawali, Melina Masihi, Dustin A. Carlson, Peter J. Kahrilas , et al. · 2022

INTRODUCTION: Ambulatory reflux monitoring performed off proton pump inhibitor (PPI) is the gold standard diagnostic test for nonerosive gastroesophageal reflux disease (GERD). However, the diagnostic metrics and optimal duration of monito…

Opioid Exposure Differentially Impacts Esophageal Body Contraction Over the Lower Esophageal Sphincter Open

Dhyanesh A. Patel, James Goss, Muhammad Hashim Hayat, Claudio Tombazzi, Rishi D. Naik , et al. · 2022

Knowledge gaps in the management of refractory reflux‐like symptoms: Healthcare provider survey Open

David Armstrong, A. P. S. Hungin, Peter J. Kahrilas, Daniel Sifrim, Paul Sinclair , et al. · 2022

Background Refractory reflux‐like symptoms have a substantial impact on patients and healthcare providers. The aim of the survey was to qualitatively assess the needs and attitudes of practicing clinicians around the management of refracto…

Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics Open

Dhyanesh A. Patel, Rena Yadlapati, Michael F. Vaezi · 2022

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review Open

Rena Yadlapati, C. Prakash Gyawali, John E. Pandolfino, Kenneth J. Chang, Peter J. Kahrilas , et al. · 2022

Objective ambulatory pH monitoring and subjective symptom assessment of gastroesophageal reflux disease show type of carbohydrate and type of fat matter Open

Cihang Gu, Timothy Olszewski, Michael F. Vaezi, Kevin D. Niswender, Heidi J. Silver · 2022

Background: Rising prevalence of gastroesophageal reflux disease (GERD) in US Veterans is concurrent with increasing excess body weight. Objective: The objective of this cross-sectional study is to examine relationships between dietary mac…

Study of Acid-related Disorders: Real-world Physician and Patient Perspectives on Burden of Helicobacter pylori Infection Open

Colin W. Howden, Stuart J. Spechler, Michael F. Vaezi, A. Mark Fendrick, Christian Atkinson , et al. · 2022

Rena Yadlapati, Peter J. Kahrilas, Mark Fox, Albert J. Bredenoord, C. Prakash Gyawali , et al. · 2021

La Clasificación de Chicago v4.0 (CCv4.0) es el esquema actualizado para clasificar las alteraciones de la motilidad esofágica utilizando la métrica de la manometría de alta resolución (HRM). Para desarrollar la CCv4.0, 52 expertos interna…

Long-Term Treatment of Eosinophilic Esophagitis With Budesonide Oral Suspension Open

Evan S. Dellon, Margaret H. Collins, David A. Katzka, Vincent A. Mukkada, Gary W. Falk , et al. · 2021

For induction full responders, continuing BOS numerically improved maintenance of efficacy vs withdrawal. A longer therapy duration did not raise safety concerns. (ClinicalTrials.gov: NCT02736409.).

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Joel E. Richter, Donald O. Castell, David A. Katzka, Philip O. Katz, A. J. P. M. Smout , et al. · 2021

Association of Achalasia With Active Varicella Zoster Virus Infection of the Esophagus Open

Rishi D. Naik, Michael F. Vaezi, Anne A. Gershon, Tina Higginbotham, Jason Chen , et al. · 2021

Development of quality indicators for the diagnosis and management of achalasia Open

A. N. Kamal, Priya Kathpalia, Fouad Otaki, Albert J. Bredenoord, Donald O. Castell , et al. · 2021

Background The management of achalasia has improved due to diagnostic and therapeutic innovations. However, variability in care delivery remains and no established measures defining quality of care for this population exist. We aimed to us…

Mucosal Integrity Testing Can Detect Differences in the Rectums of Patients with Inflammatory Bowel Disease Compared to Controls: A Pilot Study Open

Miles Basil, David A. Schwartz, Robin Dalal, Sara Horst, Elizabeth Scoville , et al. · 2021

Rectal MI is significantly higher in patients with IBD versus controls. Future studies are needed to determine how this information can be used clinically.

Rena Yadlapati, Peter J. Kahrilas, Mark Fox, Albert J. Bredenoord, C. Prakash Gyawali , et al. · 2020

Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high‐resolution manometry (HRM). Fifty‐two diverse international experts separated into seven working subgroups …

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