Fredrik Barrenäs
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View article: Deep Integrated Network Analysis – a data-driven tool to discover and characterize disease pathways in the liver
Deep Integrated Network Analysis – a data-driven tool to discover and characterize disease pathways in the liver Open
Background & Aims An extensive number of studies have utilized transcriptomic profiling as a valuable tool for uncovering genes related to diseases and physiological processes of the liver. Here we combine this wealth of information to pro…
View article: Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment
Machine Learning-Based Analysis of Glioma Grades Reveals Co-Enrichment Open
Gliomas develop and grow in the brain and central nervous system. Examining glioma grading processes is valuable for improving therapeutic challenges. One of the most extensive repositories storing transcriptomics data for gliomas is The C…
View article: Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy Open
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with strain 68–1 Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent cle…
View article: Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data Open
Transcriptomic analyses are commonly used to identify differentially expressed genes between patients and controls, or within individuals across disease courses. These methods, whilst effective, cannot encompass the combinatorial effects o…
View article: Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy
Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy Open
Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of hi…
View article: Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition
Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition Open
The recombinant Canarypox ALVAC-HIV/gp120/alum vaccine regimen was the first to significantly decrease the risk of HIV acquisition in humans, with equal effectiveness in both males and females. Similarly, an equivalent SIV-based ALVAC vacc…
View article: African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity
African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity Open
Unlike HIV infection, SIV infection is generally nonpathogenic in natural hosts, such as African green monkeys (AGMs), despite life-long high viral replication. Lack of disease progression was reportedly based on the ability of SIV-infecte…