Fredrik Ek
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View article: Visible‐Light‐Driven Aqueous Polymerization Enables in Situ Formation of Biocompatible, High‐Performance Organic Mixed Conductors for Bioelectronics
Visible‐Light‐Driven Aqueous Polymerization Enables in Situ Formation of Biocompatible, High‐Performance Organic Mixed Conductors for Bioelectronics Open
Polymer‐based organic mixed ion‐electron conductors (OMIECs) are a class of materials offering unique coupled dual charge transport characteristics along with appealing properties including mechanical softness, biocompatibility, tunability…
View article: Visible‐Light‐Driven Aqueous Polymerization Enables in Situ Formation of Biocompatible, High‐Performance Organic Mixed Conductors for Bioelectronics
Visible‐Light‐Driven Aqueous Polymerization Enables in Situ Formation of Biocompatible, High‐Performance Organic Mixed Conductors for Bioelectronics Open
Polymer‐based organic mixed ion‐electron conductors (OMIECs) are a class of materials offering unique coupled dual charge transport characteristics along with appealing properties including mechanical softness, biocompatibility, tunability…
View article: Injectable bioresorbable conductive hydrogels for multimodal brain tumor electroimmunotherapy
Injectable bioresorbable conductive hydrogels for multimodal brain tumor electroimmunotherapy Open
Current electrode technologies are too rigid for safe and effective delivery of electrotherapy in the brain, and patients with glioblastoma continue to face a devastating prognosis, with median survival stalled at 15 months despite intensi…
View article: Injectable Bioresorbable Conductive Hydrogels for Multimodal Brain Tumor Electroimmunotherapy
Injectable Bioresorbable Conductive Hydrogels for Multimodal Brain Tumor Electroimmunotherapy Open
Current electrode technologies are too rigid for safe and effective delivery of electrotherapy in the brain, and patients with glioblastoma continue to face a devastating prognosis, with median survival stalled at 15 months despite intensi…
View article: Lithography-Free Water Stable Conductive Polymer Nanowires
Lithography-Free Water Stable Conductive Polymer Nanowires Open
Free-standing nanowires can gain intracellular access without causing stress or apoptosis. Current approaches to generate nanowires focus on lithographic patterning and inorganic materials (Si, GaAs, Al2O3, etc.) whil…
View article: Lithography-free Water Stable Conductive Polymer Nanowires
Lithography-free Water Stable Conductive Polymer Nanowires Open
Free-standing nanowires can gain intracellular access without causing cellular stress or apoptosis. Current approaches to generate nanowires focus on lithographic patterning and inorganic materials (Si, GaAs, Al2O3, etc.) while organic mat…
View article: Tuning the Organic Electrochemical Transistor (OECT) Threshold Voltage with Monomer Blends
Tuning the Organic Electrochemical Transistor (OECT) Threshold Voltage with Monomer Blends Open
A novel approach is introduced to modulate the threshold voltage of organic electrochemical transistors (OECTs) that are fabricated by electropolymerizing the channel material between the source and drain electrodes. To achieve this, we ad…
View article: In Vivo Photopolymerization: Achieving Detailed Conducting Patterns for Bioelectronics
In Vivo Photopolymerization: Achieving Detailed Conducting Patterns for Bioelectronics Open
Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate‐bound electrodes often result in inflammation and scarring in vivo, the…
View article: In situ assembly of an injectable cardiac stimulator
In situ assembly of an injectable cardiac stimulator Open
Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stim…
View article: Correction: High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer
Correction: High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer Open
View article: High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer
High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer Open
In normal colon tissue, oestrogen receptor alpha (ERα) is expressed at low levels, while oestrogen receptor beta (ERβ) is considered the dominant subtype. However, in colon carcinomas, the ERα/β ratio is often increased, an observation tha…
View article: Ciclopirox ethanolamine preserves the immature state of human HSCs by mediating intracellular iron content
Ciclopirox ethanolamine preserves the immature state of human HSCs by mediating intracellular iron content Open
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. To elucidate regulatory mechanisms governing the maintenance and propagation of human HSCs ex vivo, we screened libra…
View article: In situ assembly of bioresorbable organic bioelectronics in the brain
In situ assembly of bioresorbable organic bioelectronics in the brain Open
View article: In Situ Assembly of Bioresorbable Organic Bioelectronics in the Brain
In Situ Assembly of Bioresorbable Organic Bioelectronics in the Brain Open
Bioelectronics has the potential to complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to…
View article: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics Open
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static…
View article: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics Open
<p>Dataset accompanying paper: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics. </p>\n\n<p>Corresponding author: M. Berggren</p>
View article: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics Open
Dataset accompanying paper: Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics. Corresponding author: M. Berggren
View article: Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche
Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche Open
View article: Method Matters: Exploring Alkoxysulfonate-Functionalized Poly(3,4-ethylenedioxythiophene) and Its Unintentional Self-Aggregating Copolymer toward Injectable Bioelectronics
Method Matters: Exploring Alkoxysulfonate-Functionalized Poly(3,4-ethylenedioxythiophene) and Its Unintentional Self-Aggregating Copolymer toward Injectable Bioelectronics Open
Injectable bioelectronics could become an alternative or a complement to traditional drug treatments. To this end, a new self-doped p-type conducting PEDOT-S copolymer (A5) was synthesized. This copolymer formed highly water-dispers…
View article: Small Molecule Screening of Primary Human Acute Myeloid Leukemia Using Co-culture and Multiplexed FACS Analysis
Small Molecule Screening of Primary Human Acute Myeloid Leukemia Using Co-culture and Multiplexed FACS Analysis Open
Ex vivo culture of primary acute myeloid leukemia (AML) cells is notoriously difficult due to spontaneous differentiation and cell death, which hinders mechanistic and translational studies. To overcome this bottleneck, we have impl…
View article: Additional file 2 of Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche
Additional file 2 of Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche Open
Additional file 2. Supplementary Table S6.
View article: High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model
High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model Open
View article: FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation
FRET-Based Screening Identifies p38 MAPK and PKC Inhibition as Targets for Prevention of Seeded α-Synuclein Aggregation Open
View article: Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines
Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines Open
View article: FRET-based screening in HEK293T identifies p38 MAPK and PKC inhibition as therapeutic targets for α-synuclein aggregation
FRET-based screening in HEK293T identifies p38 MAPK and PKC inhibition as therapeutic targets for α-synuclein aggregation Open
Aggregation of α-synuclein is associated with neurodegeneration and a hallmark pathology in synucleinopathies. These aggregates are thought to function as prion-like particles where the conformation of misfolded α-synuclein determines the …
View article: Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells
Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells Open
Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. However, recent studies have …
View article: Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition Open
Inflammation is an established risk factor for colorectal cancer. We and others have shown that colorectal cancer patients with elevated cysteinyl leukotriene receptor 2 (CysLT 2 R) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) level…
View article: Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase Open
View article: A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia
A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia Open
Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current…
View article: Revisorers syn på EU:s revisionspaket : En studie om regelverk och prissättning av revisionstjänster
Revisorers syn på EU:s revisionspaket : En studie om regelverk och prissättning av revisionstjänster Open
Purpose - Previous studies suggest that regulatory changes result in an increased audit effort. Given a competitive market setting and audit price negotiation between the auditor and the auditee, it is unclear if an increased audit effort …