Fredrik Bergenheim
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View article: Effects of smoking on clinical treatment outcomes amongst patients with chronic inflammatory diseases initiating biologics: secondary analyses of the prospective BELIEVE cohort study
Effects of smoking on clinical treatment outcomes amongst patients with chronic inflammatory diseases initiating biologics: secondary analyses of the prospective BELIEVE cohort study Open
The prevalence and disease burden of chronic inflammatory diseases (CIDs) are predicted to rise. Patients are commonly treated with biological agents, but the individual treatment responses vary, warranting further research into optimizing…
View article: Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study
Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study Open
Background Biologic disease-modifying drugs have revolutionised the treatment of a number of chronic inflammatory diseases (CID). However, up to 60% of the patients do not have a sufficient response to treatment and there is a need for opt…
View article: A fully defined 3D matrix for ex vivo expansion of human colonic organoids from biopsy tissue
A fully defined 3D matrix for ex vivo expansion of human colonic organoids from biopsy tissue Open
Intestinal organoids have widespread research and biomedical applications, such as disease modeling, drug testing and regenerative medicine. However, the transition towards clinical use has in part been hampered by the dependency on animal…
View article: P039 Tracking intestinal epithelial cells with fluorescent dyes
P039 Tracking intestinal epithelial cells with fluorescent dyes Open
Enteroids have been shown to be able to engraft onto injured intestinal mucosa in murine experimental colitis models. This observation may provide an innovative approach to accomplish mucosal healing in patients with inflammatory bowel dis…
View article: Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy
Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy Open
Background Intestinal stem cell transplantation has been shown to promote mucosal healing and to engender fully functional epithelium in experimental colitis. Hence, stem cell therapies may provide an innovative approach to accomplish muco…
View article: COX-2–PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis
COX-2–PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis Open
Our work indicates that COX-2-PGE2 signaling could be a novel target for the management of PNRs to TNF inhibitors. We additionally demonstrate that COX-2-PGE2 signaling has dual functions during tissue repair and normal lineage differentia…