Fredrik Kahn
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View article: Vaccine protection against COVID-19 mortality in relation to time since last booster dose among nursing home residents in Sweden – A case-control study over 35 months
Vaccine protection against COVID-19 mortality in relation to time since last booster dose among nursing home residents in Sweden – A case-control study over 35 months Open
Waning vaccine protection was observed already 90 days after the last vaccine dose among older people living in nursing homes. The reported ORs imply that more than one third of all COVID-19 deaths could in the investigated setting have be…
View article: Impaired cellular immune responses to Herpes Zoster subunit vaccine in patients with rheumatoid arthritis receiving Janus kinase inhibitors
Impaired cellular immune responses to Herpes Zoster subunit vaccine in patients with rheumatoid arthritis receiving Janus kinase inhibitors Open
Objective To investigate cellular immune responses to the herpes zoster (HZ) subunit (HZ/su) vaccine in patients with rheumatoid arthritis (RA) treated with Janus Kinase inhibitors (JAKi). Methods RA patients treated with JAKi (n = 46) at …
View article: Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study
Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study Open
Dysregulation of the complement system has been proposed as a pathophysiological mechanism for Post-acute sequelae of SARS-CoV-2 (PASC). We analyzed the complement activation markers C3bc, C3bBbP and TCC in 48 PASC patients, grouped into w…
View article: Barriers and motivators associated with COVID-19 vaccination—a vaccine acceptance scoring system based on a population survey in southern Sweden
Barriers and motivators associated with COVID-19 vaccination—a vaccine acceptance scoring system based on a population survey in southern Sweden Open
Low vaccination coverage against SARS-CoV-2 (COVID-19) is a public health concern. The aim of this study was to identify barriers and motivators associated with COVID-19 vaccination and develop a vaccine acceptance scoring system. From the…
View article: Anti-SARS-CoV-2 nucleocapsid antibodies to detect exposure to SARS-CoV-2: results from a prospective cohort study on COVID-19 vaccination
Anti-SARS-CoV-2 nucleocapsid antibodies to detect exposure to SARS-CoV-2: results from a prospective cohort study on COVID-19 vaccination Open
Repeated monitoring of N-antigen antibody levels may be a valuable tool for assessing SARS-CoV-2 exposure and thus aid in monitoring transmission thereby helping in guiding vaccination strategies.
View article: Outcomes of the COVID-19 pandemic in chronic lymphocytic leukemia: focus on the very early period and Omicron era
Outcomes of the COVID-19 pandemic in chronic lymphocytic leukemia: focus on the very early period and Omicron era Open
Individuals with chronic lymphocytic leukemia (CLL) face an increased risk for severe COVID-19. This study from Sweden, a country that only had a few mandatory restrictions at the onset of the pandemic, used 10 nationwide registers to comp…
View article: NETQUANT2: automated web-based quantification of neutrophil extracellular traps from fluorescence microscopy
NETQUANT2: automated web-based quantification of neutrophil extracellular traps from fluorescence microscopy Open
Neutrophil extracellular traps (NETs) are structures that neutrophils form in response to various stimuli, including invading pathogens. NETs are increasingly studied, and their importance has been demonstrated in autoimmunity and infectio…
View article: Severity of COVID-19 in Individuals with Chronic Lymphocytic Leukemia throughout the Pandemic in Sweden: A Nationwide Multiple Register Cohort Study Conducted from 2020 to 2023
Severity of COVID-19 in Individuals with Chronic Lymphocytic Leukemia throughout the Pandemic in Sweden: A Nationwide Multiple Register Cohort Study Conducted from 2020 to 2023 Open
Introduction Due to disease- and treatment-related immune defects, patients with chronic lymphocytic leukemia (CLL) have an increased risk of severe disease and death from COVID-19, as well as impaired responses to SARS-CoV-2 vaccination. …
View article: Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort Open
Background There is no consensus or clinical guidelines for screening routines of autoimmune disease in individuals with juvenile idiopathic arthritis (JIA), since results are conflicting whether the risk for such conditions is increased o…
View article: Risk of COVID-19 hospitalisation by HIV-status and SARS-CoV-2 vaccination status during pre- and post-Omicron era in a national register-based cohort study in Sweden
Risk of COVID-19 hospitalisation by HIV-status and SARS-CoV-2 vaccination status during pre- and post-Omicron era in a national register-based cohort study in Sweden Open
This nationwide study, including mostly well-treated PLHIV, highlights the importance of vaccination with booster dose/s for effective protection against severe COVID-19 in PLHIV.KEY POINTPeople living with HIV compared to people without H…
View article: Synovial fibroblasts from children with oligoarticular juvenile idiopathic arthritis induce migration and prolong viability of neutrophils
Synovial fibroblasts from children with oligoarticular juvenile idiopathic arthritis induce migration and prolong viability of neutrophils Open
Introduction Little is known of the processes that trigger neutrophil activation in the joint of patients with oligoarticular juvenile idiopathic arthritis (oJIA), and if synovial fibroblasts (S-Fib) play an important role in the activatio…
View article: Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort Open
Background There is no consensus or clinical guidelines for screening routines of autoimmune disease in individuals with juvenile idiopathic arthritis (JIA), since results are conflicting whether the risk for such conditions is increased o…
View article: Population scale proteomics enables adaptive digital twin modelling in sepsis
Population scale proteomics enables adaptive digital twin modelling in sepsis Open
Sepsis is one of the leading causes of mortality in the world. Currently, the heterogeneity of sepsis makes it challenging to determine the molecular mechanisms that define the syndrome. Here, we leverage population scale proteomics to ana…
View article: Previous SARS-CoV-2 infections and their impact on the protection from reinfection during the Omicron BA.5 wave – a nested case-control study among vaccinated adults in Sweden
Previous SARS-CoV-2 infections and their impact on the protection from reinfection during the Omicron BA.5 wave – a nested case-control study among vaccinated adults in Sweden Open
These findings suggest that infection-induced immunity contributes to short-term population protection against infection with the subvariant BA.5 among working-age vaccinated individuals but wanes considerably with time, independent of the…
View article: Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts
Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts Open
Background Revised diagnostic criteria for infective endocarditis (IE), the 2023 Duke-ISCVID criteria, were recently presented and need validation. Here, we compare the 2000 modified Duke criteria for IE with Duke-ISCVID among patients wit…
View article: Development of cardiac ultrasonographic and clinical findings in 104 Warmblood horses – a retrospective study
Development of cardiac ultrasonographic and clinical findings in 104 Warmblood horses – a retrospective study Open
Development of cardiac ultrasonographic and clinical findings in 104 Warmblood horses -a retrospective studyAssessing the prognosis of clinical cardiological and echocardiographic findings in warm-blooded horses is a major challenge.Noneth…
View article: Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months
Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months Open
Given the waning of protection against death, continuous surveillance of population immunity status, particularly among the most vulnerable population groups, could help to further fine-tune vaccination recommendations.
View article: HYPOGAMMAGLOBULINEMIA AT DIAGNOSIS IS ASSOCIATED WITH INFERIOR SURVIVAL AND HIGHER RISK OF INFECTIONS IN DIFFUSE LARGE B CELL LYMPHOMA: A RETROSPECTIVE STUDY FROM SWEDEN
HYPOGAMMAGLOBULINEMIA AT DIAGNOSIS IS ASSOCIATED WITH INFERIOR SURVIVAL AND HIGHER RISK OF INFECTIONS IN DIFFUSE LARGE B CELL LYMPHOMA: A RETROSPECTIVE STUDY FROM SWEDEN Open
Introduction: Low level of antibody production does not only increase the risk of infections, but also the incidence of malignancies, especially lymphoma. The primary aim of this study was to explore if hypogammaglobulinemia in untreated d…
View article: Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions
Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions Open
Introduction Monocytes are key effector cells in inflammatory processes. We and others have previously shown that synovial monocytes in childhood-onset arthritis are activated. However, very little is known about how they contribute to dis…
View article: Synovial Monocytes Drive the Pathogenesis in Oligoarticular Juvenile Idiopathic Arthritis via IL-6/JAK/STAT Signalling and Cell-Cell Interactions
Synovial Monocytes Drive the Pathogenesis in Oligoarticular Juvenile Idiopathic Arthritis via IL-6/JAK/STAT Signalling and Cell-Cell Interactions Open
Objectives Synovial monocytes in oligoarticular juvenile idiopathic arthritis (oJIA) are polarized, but little is known of how they contribute to disease and attain their pathogenic features. The aim of this study was to investigate the ro…
View article: Identification of novel autoantigens as potential biomarkers in juvenile idiopathic arthritis associated uveitis
Identification of novel autoantigens as potential biomarkers in juvenile idiopathic arthritis associated uveitis Open
Background Many children with juvenile idiopathic arthritis (JIA) have autoantibodies, targeting nuclear components (anti-nuclear antibodies, ANA). ANA in JIA is associated with uveitis, an eye inflammation which may cause permanent vision…
View article: The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
The risk of depression and anxiety is not increased in individuals with juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort Open
Background Children with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-b…