Fredrika Hellgren
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View article: Multivalent Antigen Display on Nanoparticles Diversifies B Cell Responses
Multivalent Antigen Display on Nanoparticles Diversifies B Cell Responses Open
Nanoparticles for multivalent display and delivery of vaccine antigens have emerged as a promising avenue for enhancing B cell responses to protein subunit vaccines. Here, we evaluated B cell responses in rhesus macaques immunized with pre…
Immune responses to mRNA vaccines : characteristics & the impact of host immune status Open
mRNA vaccines played a critical role in combating the SARS-CoV-2 pandemic and are progressing toward wider clinical use. However, much of how mRNA vaccines act upon the immune system to induce protection remains incompletely understood. Th…
Immune responses to mRNA vaccines : characteristics & the impact of host immune status Open
mRNA vaccines played a critical role in combating the SARS-CoV-2 pandemic and are progressing toward wider clinical use. However, much of how mRNA vaccines act upon the immune system to induce protection remains incompletely understood. Th…
View article: Biochemical and hematological reference intervals in rhesus and cynomolgus macaques and implications for vaccine and drug development
Biochemical and hematological reference intervals in rhesus and cynomolgus macaques and implications for vaccine and drug development Open
Nonhuman primates have a key role in the evaluation of novel therapeutics including vaccine and drug development. Monitoring biochemical and hematological parameters of macaques is critical to understand toxicity and safety, but general re…
Scifer: An R/Bioconductor package for large-scale integration of Sanger sequencing and flow cytometry data of index-sorted single cells Open
Here you will find all the data, code, and analysis used for the scifer manuscript. scifer is an R/Bioconductor package that can preprocess raw data from index sorts and raw BCR Sanger sequencing data. It can identify high-quality sequence…
View article: Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans
Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans Open
mRNA vaccines are likely to become widely used for the prevention of infectious diseases in the future. Nevertheless, a notable gap exists in mechanistic data, particularly concerning the potential effects of sequential mRNA immunization o…
View article: Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses
Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses Open
This repository contains the code and processed datasets used for the entitled project published in Nature Communications, 2023.
View article: Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques
Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques Open
Targeting CD40 by agonistic antibodies used as vaccine adjuvants or for cancer immunotherapy is a strategy to stimulate immune responses. The majority of studied agonistic anti-human CD40 antibodies require crosslinking of their Fc region …
Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19 Open
Effective humoral immune responses require well-orchestrated cellular interactions between B and T follicular helper (Tfh) cells. Whether this interaction is impaired and associated with COVID-19 disease severity is unknown. Here, longitud…
Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity Open
The immunopathology of coronavirus disease 2019 (COVID-19) remains enigmatic, causing immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSCs) are T cell suppressors that expand in inflammatory condi…
Functional myeloid-derived suppressor cells expand in blood but not airways of COVID-19 patients and predict disease severity Open
The immunopathology of COVID-19 remains enigmatic, exhibiting immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells (M-MDSC) are T cell suppressors that expand in inflammatory conditions, but their role in …
Deficits in the IgG<sup>+</sup> memory B‐cell recovery after anthracycline treatment is confined to the spleen of rhesus macaques Open
Objectives Loss of vaccine‐induced antibodies (Abs) after chemotherapy against paediatric acute lymphoblastic leukaemia (ALL) is common and often necessitates re‐immunisation after cessation of treatment. Even so, some ALL survivors fail t…
View article: Corrigendum: Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
Corrigendum: Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells Open
In the original article ** Liang F, Lindgren G, Lin A, Thompson EA, Ols S, Röhss J, John S, Hassett K, Yuzhakov O, Bahl K, Brito LA, Salter H, Ciaramella G, Loré K. Efficient Targeting and Activation of Antigen Presenting Cells In Vivo aft…
View article: Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells Open
[This corrects the article DOI: 10.3389/fimmu.2017.01539.].