Friedrich Krätzer
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View article: In vitro and in vivo drug disposition of cilengitide in animals and human
In vitro and in vivo drug disposition of cilengitide in animals and human Open
Cilengitide is very low permeable (1.0 nm/sec) stable cyclic pentapeptide containing an Arg‐Gly‐Asp motif responsible for selective binding to α v β 3 and α v β 5 integrins administered intravenously (i.v.). In vivo studies in the mouse an…