Froso Karaiskaki
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View article: Uncovering the mode of action of engineered T cells in patient cancer organoids
Uncovering the mode of action of engineered T cells in patient cancer organoids Open
Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro models that reveal therapeutic modes of action at the molecular level. Here we describe a system, called BE…
View article: γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults
γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults Open
γ9δ2T cells fill a distinct niche in human immunity due to the unique physiology of the phosphoantigen-reactive γ9δ2TCR. Here, we highlight reproducible TCRδ complementarity-determining region 3 (CDR3δ) repertoire patterns associated with …
View article: Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds
Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds Open
Background γ9δ2 T cells hold great promise as cancer therapeutics because of their unique capability of reacting to metabolic changes with tumor cells. However, it has proven very difficult to translate this promise into clinical success. …
View article: αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies
αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies Open
We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral blood derived stem cells from matched related, o…
View article: γ9δ2T cell diversity and the receptor interface with tumor cells
γ9δ2T cell diversity and the receptor interface with tumor cells Open
γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we explored the clona…