Lianfu Deng
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View article: Cancer associated fibroblast exosomal miR-214-3p regulated by hnRNPA2B1 promotes cisplatin resistance by inhibiting ferroptosis
Cancer associated fibroblast exosomal miR-214-3p regulated by hnRNPA2B1 promotes cisplatin resistance by inhibiting ferroptosis Open
Background: Cisplatin resistance continues to represent a significant clinical challenge in the treatment of osteosarcoma. Accumulating evidence suggests that cancer-associated fibroblast (CAF) play a pivotal role in shaping a chemotherapy…
View article: Exosomal miR-20a-5p derived from cisplatin-resistant osteosarcoma cells promotes chemoresistance via Inhibition of ferroptosis through targeting RUNX3
Exosomal miR-20a-5p derived from cisplatin-resistant osteosarcoma cells promotes chemoresistance via Inhibition of ferroptosis through targeting RUNX3 Open
Cisplatin resistance continues to pose a significant challenge in the treatment of osteosarcoma, markedly impairing clinical outcomes. Accumulating evidence indicates that exosomal microRNAs (miRNAs) facilitate intercellular communication …
View article: Swin-X2S: Reconstructing 3D Shape from 2D Biplanar X-ray with Swin Transformers
Swin-X2S: Reconstructing 3D Shape from 2D Biplanar X-ray with Swin Transformers Open
The conversion from 2D X-ray to 3D shape holds significant potential for improving diagnostic efficiency and safety. However, existing reconstruction methods often rely on hand-crafted features, manual intervention, and prior knowledge, re…
View article: Correction: An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration
Correction: An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration Open
Correction for ‘An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration’ by Xingzhi Liu et al. , Mater. Horiz. , 2018, 5 , 1082–1091, https://doi.org/10.1039/C8MH00704G.
View article: USP26 Combats Age‐Related Declines in Self‐Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis
USP26 Combats Age‐Related Declines in Self‐Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis Open
Age‐related declines in self‐renewal and multipotency of bone marrow mesenchymal stem cells (BMSCs) limit their applications in tissue engineering and clinical therapy. Thus, understanding the mechanisms behind BMSC senescence is crucial f…
View article: Positioning regulation of organelle network via Chinese microneedle
Positioning regulation of organelle network via Chinese microneedle Open
The organelle network is a key factor in the repair and regeneration of lesion. However, effectively intervening in the organelle network which has complex interaction mechanisms is challenging. In this study, on the basis of electromagnet…
View article: Correction to “Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy”
Correction to “Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy” Open
In the originally published paper, in Figure S7 (Supporting Information), due to the computer lag caused by the large amount of processing fluorescence data for live/dead staining of cells, we accidentally copied the wrong pictures for the…
View article: Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA
Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA Open
Forsythia suspensa tea is a popular traditional Chinese medicine decoction for its healthy and therapeutic benefits. However, its effects in bone metabolism were not clear. In recent study, we uncovered anti‐osteoclastogenesis property of …
View article: Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis
Injectable Nano‐Micro Composites with Anti‐bacterial and Osteogenic Capabilities for Minimally Invasive Treatment of Osteomyelitis Open
The effective management of osteomyelitis remains extremely challenging due to the difficulty associated with treating bone defects, the high probability of recurrence, the requirement of secondary surgery or multiple surgeries, and the di…
View article: Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres
Regulating Chondro‐Bone Metabolism for Treatment of Osteoarthritis via High‐Permeability Micro/Nano Hydrogel Microspheres Open
Destruction of cartilage due to the abnormal remodeling of subchondral bone (SB) leads to osteoarthritis (OA), and restoring chondro‐bone metabolic homeostasis is the key to the treatment of OA. However, traditional intra‐articular injecti…
View article: A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium Open
The skeleton is an important structural and metabolic organ in human body, while aging is the physiological basis for degenerative skeletal diseases. China has the largest aging population in the world and faces great challenges in prevent…
View article: Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation
Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation Open
A fundamental understanding of inflammation and tissue healing suggests that the precise regulation of the inflammatory phase, both in terms of location and timing, is crucial for bone regeneration. However, achieving the activation of ear…
View article: Geometric Angles and Gene Expression in Cells for Structural Bone Regeneration
Geometric Angles and Gene Expression in Cells for Structural Bone Regeneration Open
Geometry and angles play crucial roles in cellular processes; however, its mechanisms of regulation remain unclear. In this study, a series of three dimensional (3D)‐printed microfibers with different geometries is constructed using a near…
View article: Circadian Clock Regulation via Biomaterials for Nucleus Pulposus (Adv. Mater. 32/2023)
Circadian Clock Regulation via Biomaterials for Nucleus Pulposus (Adv. Mater. 32/2023) Open
Tissue Regeneration Inspired by the regulation of cellular circadian clock on tissue regeneration, in article number 2301037, Huitong Ruan, Wenguo Cui, Lianfu Deng, and co-workers report circadian-clock-regulating biomaterials that are fab…
View article: A Biomaterial‐Based Hedging Immune Strategy for Scarless Tendon Healing
A Biomaterial‐Based Hedging Immune Strategy for Scarless Tendon Healing Open
Adv. Mater. 2022, 34, 2200789 DOI: 10.1002/adma.202200789 In assembling the figures of the paper, the authors made errors in several of the figures. In Figure 2e and 4e, adjacent images for 2 of the subpanels were accidentally repeated. In…
View article: 3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis (Adv. Sci. 16/2023)
3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis (Adv. Sci. 16/2023) Open
3D Biomimetic Calcified Cartilaginous Callus Based on the natural bone repair process, a 3D biomimetic calcified cartilaginous callus (PHS) is prepared using calcium ion chelation and 3D printing technology to promote the regeneration of l…
View article: 3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis
3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis Open
The formation of a calcified cartilaginous callus (CACC) is crucial during bone repair. CACC can stimulate the invasion of type H vessels into the callus to couple angiogenesis and osteogenesis, induce osteoclastogenesis to resorb the calc…
View article: Visualizable and Lubricating Hydrogel Microspheres Via NanoPOSS for Cartilage Regeneration
Visualizable and Lubricating Hydrogel Microspheres Via NanoPOSS for Cartilage Regeneration Open
The monitoring of tissue regeneration is particularly important. However, most materials do not allow direct observation of the regeneration process in the cartilage layer. Here, using sulfhydryl polyhedral oligomeric silsesquioxane (POSS‐…
View article: Engineered extracellular vesicles for ischemic stroke treatment
Engineered extracellular vesicles for ischemic stroke treatment Open
Dear Editor, Nanotechnology-based therapeutic strategies have been proven effective in diseases including cancer, infection, inflammation, etc.1Machtakova M. Thérien-Aubin H. Landfester K. Polymer nano-systems for the encapsulation and del…
View article: Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing
Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing Open
Mechanical activation of fibroblasts, caused by friction and transforming growth factor–β1 recognition, is one of the main causes of tissue adhesions. In this study, we developed a lubricated gene-hydrogel patch, which provides both a moti…
View article: A general method for endowing hydrophobic nanoparticles with water dispersion abilities
A general method for endowing hydrophobic nanoparticles with water dispersion abilities Open
We have developed a generally applicable method involving using dimercaptosuccinic acid (DMSA) for endowing hydrophobic inorganic nanoparticles with water dispersion abilities.
View article: In Situ Sustained Macrophage-Targeted Nanomicelle–Hydrogel Microspheres for Inhibiting Osteoarthritis
In Situ Sustained Macrophage-Targeted Nanomicelle–Hydrogel Microspheres for Inhibiting Osteoarthritis Open
There are still challenges in applying drug nanocarriers for in situ sustained macrophage targeting and regulation, due to the rapid clearance of nanocarriers and burst drug release in vivo. Herein, a nanomicelle–hydrogel microsphere, char…
View article: Vascularized polypeptide hydrogel modulates macrophage polarization for wound healing
Vascularized polypeptide hydrogel modulates macrophage polarization for wound healing Open
Wound repair involves a sophisticated process that includes angiogenesis, immunoregulation and collagen deposition. However, weak revascularization performance and the lack of biochemical cues to trigger immunomodulatory function currently…
View article: Inflammation Self‐Limiting Electrospun Fibrous Tape via Regional Immunity for Deep Soft Tissue Repair
Inflammation Self‐Limiting Electrospun Fibrous Tape via Regional Immunity for Deep Soft Tissue Repair Open
Small 2022, 18, 2203265 DOI: 10.1002/smll.202203265 In the originally published article, Figure 9B contained errors. When preparing the figure, the PLA and PG samples were mislabeled, leading to the wrong samples being presented in the fig…
View article: Construction of Biomimetic Tissues with Anisotropic Structures via Stepwise Algorithm‐Assisted Bioprinting (Small 46/2022)
Construction of Biomimetic Tissues with Anisotropic Structures via Stepwise Algorithm‐Assisted Bioprinting (Small 46/2022) Open
In article number 2204316, Kan Wang, Jinwu Wang, Wenguo Cui, and co-workers develop a stepwise algorithm-assisted bioprinting technology for the construction of biomimetic tissues with a customizable anisotropic microstructure.Anisotropic …
View article: MScanFit motor unit number estimation of abductor pollicis brevis: Findings from different experimental parameters
MScanFit motor unit number estimation of abductor pollicis brevis: Findings from different experimental parameters Open
MScanFit motor unit number estimation (MUNE) based on the recording of the compound muscle action potential (CMAP) scan has wide applications. This study evaluated the effect of different CMAP scan settings on MScanFit MUNE. CMAP scan of t…
View article: Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-κB Ligand
Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-κB Ligand Open
Receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, play pivotal roles in bone remodeling. The monoclonal antibody denosumab successfully inhibited the maturation of osteoclasts (OCs) by binding to RANKL in the clinic. We…