Explanipedia

Variant electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging Open

Job Stoks, Kiran Haresh Kumar Patel, Bianca van Rees, Uyên Châu Nguyên, Casper Mihl , et al. · 2024

Background and aims Although electrical activity of the normal human heart is well-characterized by the 12-lead electrocardiogram, detailed insights into within-subject and between-subject variations of ventricular activation and recovery …

Post-GWAS machine learning prioritizes key genes regulating blood pressure Open

Hannah Nicholls, Fu Liang Ng, David Watson, Julius O.B. Jacobsen, Helen R. Warren , et al. · 2023

Over one thousand blood pressure (BP) loci have been identified by genetic association studies. However, determination of causal genes remains a bottleneck for further translational discovery. Here we triage genes identified by a BP genome…

Health equality, race and pharmacogenomics Open

Emma Magavern, Deepti Gurdasani, Fu Liang Ng, Sandra Soo‐Jin Lee · 2021

Pharmacogenomics is increasingly moving into mainstream clinical practice. Careful consideration must be paid to inclusion of diverse populations in research, translation and implementation, in the historical and social context of populati…

A retrospective cohort study of risk factors and outcomes in older patients admitted to an inner-city geriatric unit in London during first peak of COVID-19 pandemic Open

Carmela Maniero, Devan Patel, Asha Pavithran, Prasheena Naran, Fu Liang Ng , et al. · 2021

An Academic Clinician’s Road Map to Hypertension Genomics Open

Emma Magavern, Helen R. Warren, Fu Liang Ng, Claudia Cabrera, Patricia B. Munroe , et al. · 2021

At the dawn of the new decade, it is judicious to reflect on the boom of knowledge about polygenic risk for essential hypertension supplied by the wealth of genome-wide association studies. Hypertension continues to account for significant…

Candidates registered for reasonable adjustments underperform compared to other candidates in the national undergraduate Prescribing Safety Assessment: Retrospective cohort analysis (2014–2018) Open

Kate Hutchinson, William Ricketts, Simon Maxwell, Fu Liang Ng · 2020

Aims Candidates with disabilities are eligible for reasonable adjustments (RA) while undertaking the national Prescribing Safety Assessment (PSA). The PSA is a novel open‐book, time‐constrained, multiformat assessment that may pose challen…

Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated Open

Claudia Cabrera, Fu Liang Ng, Hannah Nicholls, Ajay Gupta, Michael R. Barnes , et al. · 2019

High blood pressure (BP) remains the major heritable and modifiable risk factor for cardiovascular disease. Persistent high BP, or hypertension, is a complex trait with both genetic and environmental interactions. Despite swift advances in…

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits Open

Εvangelos Εvangelou, Helen R. Warren, David Mosén-Ansorena, Borbála Mifsud, Raha Pazoki , et al. · 2018

UK survey of non-medical use of prescription drugs (NMURx) as a valuable source of general population illicit drug use data Open

Fu Liang Ng, Karilynn Rockhill, Joshua C. Black, Kevin P. May, Melanie D. Whittington , et al. · 2018

Purpose of study The aim of the study is to describe the prevalence of illicit drug use in England and Wales using data from the UK Survey of Non-Medical Use of Prescription Drugs (NMURx) programme and to compare against the well-establish…

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits Open

Εvangelos Εvangelou, Helen R. Warren, David Mosén-Ansorena, Borbála Mifsud, Raha Pazoki , et al. · 2018

Hypertension genomics and cardiovascular prevention Open

Fu Liang Ng, Helen R. Warren, Mark J. Caulfield · 2018

Hypertension continues to be a major risk factor for global mortality, and recent genome-wide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. In light of t…

Attenuation of Splanchnic Autotransfusion Following Noninvasive Ultrasound Renal Denervation: A Novel Marker of Procedural Success Open

Manish Saxena, T. Shour, Mussadiq Shah, C. B. Wolff, Peter O.O. Julu , et al. · 2018

Background Renal denervation has no validated marker of procedural success. We hypothesized that successful renal denervation would reduce renal sympathetic nerve signaling demonstrated by attenuation of α‐1‐adrenoceptor‐mediated autotrans…

Genetic analysis of over one million people identifies 535 novel loci for blood pressure Open

Εvangelos Εvangelou, Helen R. Warren, David Mosén-Ansorena, Borbála Mifsud, Raha Pazoki , et al. · 2017

High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people …

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle Open

Meixia Ren, Fu Liang Ng, Helen R. Warren, Kate Witkowska, Michael Baron , et al. · 2017

Elevated blood pressure (BP) is a major global risk factor for cardiovascular disease. Genome-wide association studies have identified several genetic variants at the NPR3 locus associated with BP, but the functional impact of these varian…

The Impact of the Blood Pressure- Associated Genetic Locus at SLC4A7 on Gene Expression and Intracellular pH Regulation Open

Fu Liang Ng · 2017

Increased NBCn1 expression, Na + /HCO 3 - co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension Open

Fu Liang Ng, Ebbe Boedtkjer, Katarzyna Witkowska, Meixia Ren, Ruoxin Zhang , et al. · 2017

Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/HCO3- co-transporter NBCn1 which regulates intracellular pH (pHi). We conducted a …

A blood pressure-associated variant of theSLC39A8gene influences cellular cadmium accumulation and toxicity Open

Ruoxin Zhang, Kate Witkowska, José Afonso Guerra‐Assunção, Meixia Ren, Fu Liang Ng , et al. · 2016

Genome-wide association studies have revealed a relationship between inter-individual variation in blood pressure and the single nucleotide polymorphism rs13107325 in the SLC39A8 gene. This gene encodes the ZIP8 protein which co-transports…

Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction Open

Wei Yang, Fu Liang Ng, Kenneth Chan, Xiangyuan Pu, Robin N. Poston , et al. · 2016

Genome-wide association studies have revealed an association between coronary heart disease (CHD) and genetic variation on chromosome 13q34, with the lead single nucleotide polymorphism rs4773144 residing in the COL4A2 gene in this genomic…

Device-based Therapy for Hypertension Open

Fu Liang Ng, Manish Saxena, Felix Mahfoud, Atul Pathak, Melvin D. Lobo · 2016

Hypertension continues to be a major contributor to global morbidity and mortality, fuelled by an abundance of patients with uncontrolled blood pressure despite the multitude of pharmacological options available. This may occur as a conseq…

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