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View article: Intensive blood pressure reduction but an increased risk of peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials
Intensive blood pressure reduction but an increased risk of peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials Open
Our meta-analysis revealed that intensive reductions in SBP mediated by BP-lowering agents conferred increase the risk of PAD in patients with cardiometabolic risk factors. A gradual and moderate BP reduction as well as regular BP monitori…
View article: Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC
Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC Open
The abnormal accumulation of lipids is a hallmark of clear cell renal cell carcinoma (ccRCC). Both the thyroid hormone receptor β1 (TRβ) and peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC1α) are key regulators of…
View article: Curcumin Mitigates Microplastic-Induced Damage in Livestock and Poultry: Mechanistic Insights and Strategies for Sustainable Farming
Curcumin Mitigates Microplastic-Induced Damage in Livestock and Poultry: Mechanistic Insights and Strategies for Sustainable Farming Open
The pervasive contamination of microplastics and nanoplastics (MNPs) in livestock and poultry production systems represent a critical threat to animal health, productivity, and food safety. This review systematically evaluates the potentia…
View article: Anti-diabetic medications and cancer: links beyond glycemic and body weight control
Anti-diabetic medications and cancer: links beyond glycemic and body weight control Open
Cancer is becoming one of the leading causes of death among patients with diabetes. Hyperglycemia and obesity, two key characteristics of type 2 diabetes, modify the risks of cancer in patients with type 2 diabetes. However, recent studies…
View article: PCSK9 Inhibitor and Potential Decreased Risk of Neoplasms, Especially in Females: A Meta-Analysis
PCSK9 Inhibitor and Potential Decreased Risk of Neoplasms, Especially in Females: A Meta-Analysis Open
Background: Proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) has been reported to exhibit anti-neoplasm effects. However, the specific impacts remain uncertain. This study aims to evaluate the association between PCSK9i and…
View article: Cardiovascular and brain effects of liraglutide in transthyretin amyloidosis (ATTR) mice models
Cardiovascular and brain effects of liraglutide in transthyretin amyloidosis (ATTR) mice models Open
Aim: The effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in hereditary transthyretin amyloidosis (ATTRv) remain uncertain. This study aims to investigate whether liraglutide interacts with transthyretin protein (TTR) and th…
View article: Glucagon‐like peptide‐1 receptor agonist treatment associated weight fluctuation and influencing factors in patients with overweight or obesity
Glucagon‐like peptide‐1 receptor agonist treatment associated weight fluctuation and influencing factors in patients with overweight or obesity Open
Objective To characterize the weight fluctuation and explore its influencing factors after glucagon‐like peptide 1 receptor agonist (GLP‐1RA) treatment in patients with overweight or obesity. Methods This retrospective cohort study enrolle…
View article: A Study of China’s Image in Vietnam’s Nhan Dan (People’s Daily): A Case Study of China-Related Coverage
A Study of China’s Image in Vietnam’s Nhan Dan (People’s Daily): A Case Study of China-Related Coverage Open
This article takes all the China-related reports in Vietnam’s Nhan Dan from 2016 to 2020 as the research object, and discusses the national image of China constructed by Vietnam’s mainstream media from the aspects of the number of reports …
View article: Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients
Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients Open
BACKGROUND The association between body mass index (BMI) and bone mineral density (BMD) has shown inconsistent results, varying by sex and skeletal site. Despite normal or elevated bone mass, individuals with type 2 diabetes have an increa…
View article: Effects of Semaglutide and Tirzepatide on Bone Metabolism in Type 2 Diabetic Mice
Effects of Semaglutide and Tirzepatide on Bone Metabolism in Type 2 Diabetic Mice Open
Background/Objectives: Type 2 diabetes and weight loss are associated with detrimental skeletal health. Incretin-based therapies (GLP-1 receptor agonists, and dual GIP/GLP-1 receptor agonists) are used clinically to treat diabetes and obes…
View article: Comprehensive analysis of the integrated quality of cultivated kelp (Saccharina japonica) in three major producing provinces of China
Comprehensive analysis of the integrated quality of cultivated kelp (Saccharina japonica) in three major producing provinces of China Open
Saccharina japonica is a commercially important species in the seaweed industry, with a long history of cultivation. Understanding the differences in the integrated quality of S. japonica across major production regions is necessary for ac…
View article: Mulberry Twig Alkaloids Improved the Progression of Metabolic-Associated Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating the PGC1α/PPARα and KEAP1/NRF2 Pathways
Mulberry Twig Alkaloids Improved the Progression of Metabolic-Associated Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating the PGC1α/PPARα and KEAP1/NRF2 Pathways Open
Background/Objectives: Metabolic-associated fatty liver disease (MAFLD) is one of the most common liver disorders associated with obesity and metabolic syndrome, and poses a significant global health burden with limited effective treatment…
View article: The association between exposure to famine in early life and risks of diabetic complications in adult patients with type two diabetes
The association between exposure to famine in early life and risks of diabetic complications in adult patients with type two diabetes Open
Early-life exposure to famine in patients with type two diabetes might be associated with increased risks of coronary heart disease, cerebrovascular disease, and diabetic retinopathy but a reduced risk of diabetic kidney disease in adultho…
View article: Corrigendum to ‘JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression’[Journal of Orthopaedic Translation 44 (2024) 60–71]
Corrigendum to ‘JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression’[Journal of Orthopaedic Translation 44 (2024) 60–71] Open
[This corrects the article DOI: 10.1016/j.jot.2023.11.007.].
View article: Pregnancy Risk Assessment, Management, and Delivery Plan for Pregnant Women with Moyamoya Disease Using a Multidisciplinary Collaborative Approach: A Case Series
Pregnancy Risk Assessment, Management, and Delivery Plan for Pregnant Women with Moyamoya Disease Using a Multidisciplinary Collaborative Approach: A Case Series Open
Moyamoya disease is a rare and serious complication of pregnancy. Pregnancy and childbirth may exacerbate the progression of this disease or induce cerebrovascular accidents, with a high mortality and disability rate, which seriously threa…
View article: Five-year follow-up of neoadjuvant PD-1 inhibitor (sintilimab) in non-small cell lung cancer
Five-year follow-up of neoadjuvant PD-1 inhibitor (sintilimab) in non-small cell lung cancer Open
Background Neoadjuvant anti-programmed cell death protein-1 (PD-1) therapy exhibits potential in treating resectable non-small cell lung cancer (NSCLC). Previously, we have reported the 3-year clinical outcomes of this trial, implying the …
View article: Perirenal fat thickness contributes to the estimated 10-year risk of cardiovascular disease and atherosclerotic cardiovascular disease in type 2 diabetes mellitus
Perirenal fat thickness contributes to the estimated 10-year risk of cardiovascular disease and atherosclerotic cardiovascular disease in type 2 diabetes mellitus Open
Objective Perirenal adipose tissue (PAT) has emerged as a potential therapeutic target for cardiovascular disease (CVD). However, the relationship between increased perirenal fat thickness (PrFT) and CVD risks in individuals with type 2 di…
View article: The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: A systematic review and meta-analysis
The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: A systematic review and meta-analysis Open
There are multiple disease-modifying immunotherapies showing the potential of preventing or delaying the progression of type 1 diabetes (T1D). We designed and performed this systematic review and meta-analysis to gain an overview of what a…
View article: Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers Open
Copper ions play a crucial role as cofactors for essential enzymes in cellular processes. However, when the intracellular concentration of copper ions exceeds the homeostatic threshold, they become toxic to cells. In our study, we demonstr…
View article: Knowledge Graph Analysis of Educational Collaboration Research Based on CiteSpace
Knowledge Graph Analysis of Educational Collaboration Research Based on CiteSpace Open
Based on the relevant articles from Chinese core journals and CSSCI source journals in the CNKI China Academic Journals Full-text Database from 1994 to 2024, this study utilizes CiteSpace for visual analysis of the knowledge graph structur…
View article: The protection and research of university logo under the view of multiple legal rule
The protection and research of university logo under the view of multiple legal rule Open
With the continuous development and improvement of the social system and structure, the scope of functions of colleges and universities, as market subjects, in participating in market activities continues to expand, and the logos of colleg…
View article: Hsa_circ_0001583 fuels bladder cancer metastasis by promoting staphylococcal nuclease and tudor domain containing 1-mediated MicroRNA decay
Hsa_circ_0001583 fuels bladder cancer metastasis by promoting staphylococcal nuclease and tudor domain containing 1-mediated MicroRNA decay Open
Muscle-invasive and metastatic bladder cancer indicates extra worse prognosis. Accumulating evidence roots for the prominent role of circular RNAs(circRNAs) in bladder cancer, while the mechanisms linking circRNAs and bladder cancer metast…
View article: Retraction Note: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5
Retraction Note: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5 Open
An internal investigation of the experimental records has found that there were errors in the original data, as the analyses were performed on a single replicate.Additionally, concerns have been raised regarding high similarity of western …
View article: Dapagliflozin treatment and cardiovascular outcome in RBP4/TTR<sup>Val30Met</sup> (transthyretin cardiac amyloidosis) mice
Dapagliflozin treatment and cardiovascular outcome in RBP4/TTR<sup>Val30Met</sup> (transthyretin cardiac amyloidosis) mice Open
Aims Whether sodium‐glucose co‐transporter 2 inhibitors are effective for heart failure caused by ATTR‐CA (transthyretin cardiac amyloidosis) remains uncertain. The aim of this study is to investigate the cardiovascular prognosis in ATTR‐C…
View article: Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes: A meta-analysis
Indirect comparison of efficacy and safety of chiglitazar and thiazolidinedione in patients with type 2 diabetes: A meta-analysis Open
Diabetes mellitus is one of the most common causes of chronic kidney disease. Kidney involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney failure. The…