Explanipedia

Sex-stratified analysis of complete blood count parameters in Helicobacter pylori infection: A retrospective cohort study revealing distinct hematological mechanisms Open

Fuad Alanazi, Abdulhadi Abdulwahed, Yazeed Alshuweishi, Raed Farzan, Abdulaziz Almuqrin , et al. · 2025

Background Helicobacter pylori infection affects approximately 50% of the global population and is associated with hematological manifestations. Despite established associations with anemia, sex-specific effects remain unexplored, limiting…

Hyalomma dromedarii infesting camels in Hail Province, Saudi Arabia, carry antimicrobial resistant bacteria Open

Alanoud T. Aljasham, Sajith Raghunandanan, Raed Farzan, Abdulhadi Abdulwahed, Embalil Mathachan Aneesh , et al. · 2025

Ticks are known vectors of various pathogens and are increasingly recognized as carriers of antimicrobial-resistant (AMR) bacteria. However, the role of camel ticks in AMR transmission remains poorly understood. In this study, we investiga…

Correction: Almuhanna et al. Antibacterial, Antibiofilm, and Wound Healing Activities of Rutin and Quercetin and Their Interaction with Gentamicin on Excision Wounds in Diabetic Mice. Biology 2024, 13, 676 Open

Yasir Almuhanna, Abdulrahman Alshalani, Hamood AlSudais, Fuad Alanazi, Mohammed Alissa , et al. · 2025

In the original publication [...]

Optimizing Se- methylselenocysteine concentration to enhance glutathioneperoxidase 1 expression and mitigate oxidative stress in senescent humanfibroblast Open

Hazem K. Ghneim, Fuad Alanazi, Abdulhadi Abdulwahed, Raed Farzan, May Alrashed , et al. · 2025

Glutathione peroxidase 1 (GPx1) activity, gene expression, and several oxidative stress (OS) marker levels were investigated in the senescent passage (P) 20, 25, and 30 fibroblasts cultured in media supplemented with increasing Se-Methylse…

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen Open

Sajith Raghunandanan, Raj Priya, Gaofeng Lin, Fuad Alanazi, Andrew Zoss , et al. · 2025

In Borrelia burgdorferi , the causative agent of Lyme disease, differential gene expression is primarily governed by the alternative sigma factor RpoS (σ S ). Understanding the regulation of RpoS is crucial for elucidating how B. burgdorfe…

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen Open

Sajith Raghunandanan, Raj Priya, Gaofeng Lin, Fuad Alanazi, Andrew Zoss , et al. · 2024

In Borrelia burgdorferi , the Lyme disease pathogen, differential gene expression is primarily controlled by the alternative sigma factor RpoS (σ S ). Understanding how RpoS levels are regulated is crucial for elucidating how B. burgdorfer…

Antibacterial, Antibiofilm, and Wound Healing Activities of Rutin and Quercetin and Their Interaction with Gentamicin on Excision Wounds in Diabetic Mice Open

Yasir Almuhanna, Abdulrahman Alshalani, Hamood AlSudais, Fuad Alanazi, Mohammed Alissa , et al. · 2024

Phytochemicals are effective and are gaining attention in fighting against drug-resistant bacterial strains. In the present study, rutin and quercetin were tested for antibacterial, antibiofilm, and wound healing activities on excision wou…

Platelet/High-Density Lipoprotein Ratio (PHR) Predicts Type 2 Diabetes in Obese Patients: A Retrospective Study Open

Yazeed Alshuweishi, Arwa Abudawood, Dalal Alfayez, Abdulmalik Almufarrih, Fuad Alanazi , et al. · 2024

Background: Obesity and type 2 diabetes (T2D) pose global health problems that continue to rise. A chronic low-grade inflammation and activation of the immune system are well established in both conditions. The presence of these factors ca…

A Fur family protein BosR is a novel RNA-binding protein that controls <i>rpoS</i> RNA stability in the Lyme disease pathogen Open

Sajith Raghunandanan, Raj Priya, Fuad Alanazi, Meghan Lybecker, Paula J. Schlax , et al. · 2024

The σ54-σS sigma factor cascade plays a central role in regulating differential gene expression during the enzootic cycle of Borreliella burgdorferi, the Lyme disease pathogen. In this pathway, the primary transcription of rpoS (which enco…

BadR directly represses the expression of the glycerol utilization operon in the Lyme disease pathogen Open

Junjie Zhang, Sajith Raghunandanan, Qian Wang, Raj Priya, Fuad Alanazi , et al. · 2024

Glycerol utilization as a carbohydrate source by Borreliella burgdorferi , the Lyme disease spirochete, is critical for its successful colonization and persistence in the tick vector. The expression of the glpFKD ( glp ) operon, which enco…

A systemic approach to identify non-abundant immunogenic proteins in Lyme disease pathogens Open

Özlem Büyüktanır, Adam S. Coleman, Rachel M. Lipman, Kavita Sharma, Sajith Raghunandanan , et al. · 2023

Borrelia burgdorferi , the pathogen of Lyme disease, differentially produces many outer surface proteins (Osp), some of which represent the most abundant membrane proteins, such as OspA, OspB, and OspC. In cultured bacteria, these proteins…

The Rrp2-RpoN-RpoS pathway plays an important role in the blood-brain barrier transmigration of the Lyme disease pathogen Open

Fuad Alanazi, Sajith Raghunandanan, Raj Priya, Xiuli Yang · 2023

Lyme disease, caused by Borrelia (or Borreliella ) burgdorferi , is a complex multisystemic disorder that includes Lyme neuroborreliosis resulting from the invasion of both the central and peripheral nervous systems. However, factors that …

<i>Borrelia burgdorferi</i> c-di-AMP induces type I IFN response in macrophage through the activation of STING signaling pathway Open

Raj Priya, Sajith Raghunandanan, Fuad Alanazi, Frank Yang · 2023

Lyme disease (LD) which is caused by the spirochete Borrelia burgdorferi (Bb) poses a global health threat. Bb infection induces type I IFN response that is associated with arthritis and other symptoms. However, the ligands, PAMPs, and sig…

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