Fuat Oduncu
YOU?
Author Swipe
View article: First clinical experience of isatuximab safety and tolerability in relapsed and refractory multiple myeloma: real-world data from a compassionate use program in Germany
First clinical experience of isatuximab safety and tolerability in relapsed and refractory multiple myeloma: real-world data from a compassionate use program in Germany Open
Therapy for relapsed and refractory multiple myeloma (RRMM) remains challenging. While monoclonal antibodies against CD38 combined with pomalidomide have demonstrated efficacy in clinical trials, real-world data remain sparse. We present r…
View article: Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells
Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells Open
A number of agents designed for immunotherapy of Acute Myeloid Leukemia (AML) are in preclinical and early clinical development. Most of them target a single antigen on the surface of AML cells. Here we describe the development and key bio…
View article: MicroRNA-192-5p is a predictive biomarker of survival for Stage IIIB colon cancer patients
MicroRNA-192-5p is a predictive biomarker of survival for Stage IIIB colon cancer patients Open
The decreased expression of miRNA-192-5p found for patients with relapsing disease might represent a highly predictive marker to use for the prognosis of Stage IIIB colon cancer patients.
View article: Systematic immunohistochemical screening for mismatch repair and ERCC1 gene expression from colorectal cancers in China: Clinicopathological characteristics and effects on survival
Systematic immunohistochemical screening for mismatch repair and ERCC1 gene expression from colorectal cancers in China: Clinicopathological characteristics and effects on survival Open
Our results indicate that dMMR appeared to predictive of a survival benefit for stage III CRC patients. We also found the determination of ERCC1 expression to be useful for predicting DFS or OS for stage II and III CRC patients. In additio…
View article: Impact of age and mismatch repair status on survival in colorectal cancer
Impact of age and mismatch repair status on survival in colorectal cancer Open
Previous studies have suggested that deficiencies in mismatch repair genes ( dMMR ) often occur in patients with colorectal cancer ( CRC ) and contribute to disease etiology. Here, we looked for a correlation of MMR status to disease outco…
View article: A relationship to survival is seen by combining the factors of mismatch repair status, tumor location and age of onset in colorectal cancer patients
A relationship to survival is seen by combining the factors of mismatch repair status, tumor location and age of onset in colorectal cancer patients Open
These data demonstrate that primary tumor location can be an important factor when considered along with age of onset for the prognosis of CRC. Primary tumor location is also an important factor to evaluate the predictive effect of MMR sta…
View article: CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells
CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells Open
Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for lysis of CD19-bearing malignant B-lymphoid cells through the engagement of CD16-expr…
View article: Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells
Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells Open
Simultaneous targeting of multiple tumor-associated antigens (TAAs) in cancer immunotherapy is presumed to enhance tumor cell selectivity and to reduce immune escape.The combination of B lymphoid marker CD19 and myeloid marker CD33 is excl…
View article: Association between Ki67 Index and Clinicopathological Features in Colorectal Cancer
Association between Ki67 Index and Clinicopathological Features in Colorectal Cancer Open
Background: Conflicting results have been reported about the association between the Ki67 labeling index (Ki67-Li) and clinical outcome in patients with colorectal cancer (CRC). Patients and Methods: Ki67 expression was assessed by immunoh…
View article: Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody
Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody Open
Development of a chip-based platform for dynamic analysis of adherent and non-adherent target cell cytolysis by Natural Killer cells.