Fuchuang Zhang
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View article: Small extracellular vesicle miRNAs as biomarkers for predicting antitumor efficacy in lung adenocarcinoma treated with chemotherapy and checkpoint blockade
Small extracellular vesicle miRNAs as biomarkers for predicting antitumor efficacy in lung adenocarcinoma treated with chemotherapy and checkpoint blockade Open
Checkpoint blockade combined with chemotherapy has become an important treatment option for lung cancer patients in clinical settings. However, biomarkers that effectively identify true responders remain lacking. We assessed the potential …
View article: A weakly supervised deep learning framework for automated PD-L1 expression analysis in lung cancer
A weakly supervised deep learning framework for automated PD-L1 expression analysis in lung cancer Open
The growing application of immune checkpoint inhibitors (ICIs) in cancer immunotherapy has underscored the critical need for reliable methods to identify patient populations likely to respond to ICI treatments, particularly in lung cancer …
View article: Extracellular vesicle miRNAs for predicting the efficacy of late-line treatment with anlotinib in patients with lung adenocarcinoma
Extracellular vesicle miRNAs for predicting the efficacy of late-line treatment with anlotinib in patients with lung adenocarcinoma Open
Background Anlotinib is a targeted therapy indicated for some malignancies, including advanced non-small cell lung cancer (NSCLC). However, noninvasive biomarkers for identifying patients who will benefit from this disease remain lacking. …
View article: Correlation between immunotherapy biomarker PD-L1 expression and genetic alteration in patients with non-small cell lung cancer
Correlation between immunotherapy biomarker PD-L1 expression and genetic alteration in patients with non-small cell lung cancer Open
Programmed death-ligand 1 (PD-L1) has been widely used in immunotherapy evaluation of patients with non-small cell lung cancer (NSCLC). However, the effect is not particularly ideal, and the association between PD-L1 and genetic alteration…
View article: Artificial Intelligence-Assisted Score Analysis for Predicting the Expression of the Immunotherapy Biomarker PD-L1 in Lung Cancer
Artificial Intelligence-Assisted Score Analysis for Predicting the Expression of the Immunotherapy Biomarker PD-L1 in Lung Cancer Open
Programmed cell death ligand 1 (PD-L1) is a critical biomarker for predicting the response to immunotherapy. However, traditional quantitative evaluation of PD-L1 expression using immunohistochemistry staining remains challenging for patho…
View article: Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential
Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential Open
Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with ag…
View article: Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosets
Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosets Open
Age is the number one risk factor for breast cancer, yet the underlying mechanisms are unexplored. Age-associated mammary stem cell (MaSC) dysfunction is thought to play an important role in breast cancer carcinogenesis. Non-human primates…
View article: Murine mammary stem/progenitor cell isolation: Different method matters?
Murine mammary stem/progenitor cell isolation: Different method matters? Open
Murine mammary stem/progenitor cell isolation has been routinely used in many laboratories, yet direct comparison among different methods is lacking. In this study, we compared two frequently used digestion methods and three sets of freque…