Fujing Ge
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View article: Targeting VCP enhances colorectal cancer therapy through STING stabilization
Targeting VCP enhances colorectal cancer therapy through STING stabilization Open
Background Immunotherapy resistance in microsatellite-stable colorectal cancer (CRC) remains a major therapeutic challenge. Recent strategies to overcome the immunosuppressive tumor microenvironment have focused on reactivating innate immu…
View article: IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC
IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC Open
N6-Methyladenosine (m6A) modification is a prevalent alteration in RNA, influencing stability, localization, and translation. The m6A reader IGF2BP2 stabilizes various mRNA transcripts of oncogenic proteins…
View article: FAT1 Enhances the Sensitivity of Non‐Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway
FAT1 Enhances the Sensitivity of Non‐Small Cell Lung Cancer to VCP Inhibitors by Regulating the Activation of the Endoplasmic Reticulum Stress Pathway Open
FAT atypical cadherin 1 (FAT1) is prevalently expressed in non‐small cell lung cancer (NSCLC) tissues and is associated with poor prognosis in patients. Using data from the PRISM Repurposing drug sensitivity database, we observed that amon…
View article: Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer
Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer Open
KRAS is the most common mutated oncogenes in colorectal cancer (CRC), yet effective therapeutic strategies for targeting multiple KRAS mutations remained challenging. The prolonged protein stability of KRAS mutants contribute to their robu…
View article: UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation
UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation Open
Integrating single‐cell datasets from multiple studies provides a cost‐effective way to build comprehensive cell atlases, granting deeper insights into cellular characteristics across diverse biological systems. However, current data integ…
View article: Inflammation-related molecular signatures involved in the anticancer activities of brigatinib as well as the prognosis of EML4-ALK lung adenocarcinoma patient
Inflammation-related molecular signatures involved in the anticancer activities of brigatinib as well as the prognosis of EML4-ALK lung adenocarcinoma patient Open
View article: Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity Open
View article: The effect of PLK1 inhibitor in osimertinib resistant non-small cell lung carcinoma cells
The effect of PLK1 inhibitor in osimertinib resistant non-small cell lung carcinoma cells Open
PLK1 inhibitors have a synergistic effect with osimertinib on osimertinib-resistant NSCLC cells which indicates that they may have potential clinical value in the treatment of NSCLC patients with osimertinib resistance.
View article: Deubiquitinating enzyme JOSD2 affects susceptibility of non-small cell lung carcinoma cells to anti-cancer drugs through DNA damage repair
Deubiquitinating enzyme JOSD2 affects susceptibility of non-small cell lung carcinoma cells to anti-cancer drugs through DNA damage repair Open
Deubiquitinating enzyme JOSD2 may regulate the malignant progression of NSCLC by promoting DNA damage repair pathway, and depletion of JOSD2 significantly enhances the sensitivity of NSCLC cells to DNA damaging agents.
View article: AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner
AKR1C1 connects autophagy and oxidative stress by interacting with SQSTM1 in a catalytic-independent manner Open
View article: Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets
Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets Open
Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins. They mainly funct…