Fengxuan Han
YOU?
Author Swipe
View article: “Small Dots, Multiple Functions”: Unveiling the Veil of a Bioactive Quercetin Carbon Dot and Its Multifaceted Antibacterial and Osteogenesis Mechanisms for Infectious Bone Defect Repair
“Small Dots, Multiple Functions”: Unveiling the Veil of a Bioactive Quercetin Carbon Dot and Its Multifaceted Antibacterial and Osteogenesis Mechanisms for Infectious Bone Defect Repair Open
In infectious bone injury microenvironments, an ideal material should possess antibacterial, osteogenic, and angiogenic functions simultaneously. However, relying on a single material to achieve the above goals is challenging. In this stud…
View article: A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration
A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration Open
The distinctive structure and composition of the Haversian canal within osteons play a pivotal role in sustaining the nutritional supply to individual bone cells. Consequently, the osteon's inherent advantages in facilitating bone repair h…
View article: Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration
Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration Open
View article: “Disguise strategy” to bacteria: A multifunctional hydrogel with bacteria-targeting and photothermal conversion properties for the repair of infectious bone defects
“Disguise strategy” to bacteria: A multifunctional hydrogel with bacteria-targeting and photothermal conversion properties for the repair of infectious bone defects Open
View article: Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects
Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects Open
Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk of infection and excessive reactive oxygen species (ROS) during the early stage, and the residual bacteria and delayed Osseo integrated…
View article: Melatonin rhythm-mimicking smart hydrogel for circadian clock regulation and promotion of intervertebral disc regeneration
Melatonin rhythm-mimicking smart hydrogel for circadian clock regulation and promotion of intervertebral disc regeneration Open
View article: Assessment of the Physical Properties, drug Loadability and Release Profile, and Biocompatibility of UniPearls® Microspheres
Assessment of the Physical Properties, drug Loadability and Release Profile, and Biocompatibility of UniPearls® Microspheres Open
View article: Viscoelastic hydrogel combined with dynamic compression promotes osteogenic differentiation of bone marrow mesenchymal stem cells and bone repair in rats
Viscoelastic hydrogel combined with dynamic compression promotes osteogenic differentiation of bone marrow mesenchymal stem cells and bone repair in rats Open
A biomechanical environment constructed exploiting the mechanical property of the extracellular matrix and external loading is essential for cell behaviour. Building suitable mechanical stimuli using feasible scaffold material and moderate…
View article: Biomimetic periosteum-bone scaffolds with codelivery of BMP-2 and PDGF-BB for skull repair
Biomimetic periosteum-bone scaffolds with codelivery of BMP-2 and PDGF-BB for skull repair Open
Tissue engineering employs the use of bioactive materials to facilitate the filling and acceleration of bone defect healing, thereby introducing novel concepts to the field of in situ bone repair. Some studies have shown that periosteum pl…
View article: Progress of smart material in the repair of intervertebral disc degeneration
Progress of smart material in the repair of intervertebral disc degeneration Open
Intervertebral disc degeneration (IVDD) is a prevalent condition leading to back and leg pain as well as chronic disability. It refers to the degeneration of intervertebral disc structure, including the nucleus pulposus, annulus fibrosus, …
View article: Carbon dots‐based materials and their applications in regenerative medicine
Carbon dots‐based materials and their applications in regenerative medicine Open
Carbon dots (CDs)‐based zero‐dimensional nanomaterials with dimensions ranging from 1 to 10 nm have shown tremendous potential in the application of regenerative medicine, because of their unique physicochemical properties and favorable at…
View article: Combining "waste utilization" and "tissue to tissue" strategies to accelerate vascularization for bone repair
Combining "waste utilization" and "tissue to tissue" strategies to accelerate vascularization for bone repair Open
The utilization of autologous adipose tissue as a donor presents a more direct route toward clinical translation. Anticipated future clinical applications envision the transformation of discarded adipose tissue into a valuable resource for…
View article: The MnO2/GelMA Composite Hydrogels Improve the ROS Microenvironment of Annulus Fibrosus Cells by Promoting the Antioxidant and Autophagy through the SIRT1/NRF2 Pathway
The MnO2/GelMA Composite Hydrogels Improve the ROS Microenvironment of Annulus Fibrosus Cells by Promoting the Antioxidant and Autophagy through the SIRT1/NRF2 Pathway Open
Intervertebral disc degeneration (IVDD) is a worldwide disease that causes low back pain and reduces quality of life. Biotherapeutic strategies based on tissue engineering alternatives, such as intervertebral disc scaffolds, supplemented b…
View article: Three-dimensional bioprinting for musculoskeletal regeneration and disease modeling
Three-dimensional bioprinting for musculoskeletal regeneration and disease modeling Open
Musculoskeletal disease and injury are highly prevalent disorders that impose tremendous medical and socioeconomic burdens. Tissue engineering has attracted increasing attention as a promising technique of regenerative medicine to restore …
View article: Engineered biomimetic micro/nano-materials for tissue regeneration
Engineered biomimetic micro/nano-materials for tissue regeneration Open
The incidence of tissue and organ damage caused by various diseases is increasing worldwide. Tissue engineering is a promising strategy of tackling this problem because of its potential to regenerate or replace damaged tissues and organs. …
View article: Three-dimensional biofabrication of nanosecond laser micromachined nanofibre meshes for tissue engineered scaffolds
Three-dimensional biofabrication of nanosecond laser micromachined nanofibre meshes for tissue engineered scaffolds Open
There is a high demand for bespoke grafts to replace damaged or malformed bone and cartilage tissue. Three-dimensional (3D) printing offers a method of fabricating complex anatomical features of clinically relevant sizes. However, the cons…
View article: Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity
Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity Open
Implant-associated infection is a major threat affecting the success of orthopedic surgeries. Although various materials scavenge bacteria by generating reactive oxygen species (ROS), the intrinsic inability of ROS to distinguish bacteria …
View article: Mechanically conditioned cell sheets cultured on thermo-responsive surfaces promote bone regeneration.
Mechanically conditioned cell sheets cultured on thermo-responsive surfaces promote bone regeneration. Open
Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. However, efficient harvest and handling of cell sheets remain challenging, including ins…
View article: Building Osteogenic Microenvironments with a Double-Network Composite Hydrogel for Bone Repair
Building Osteogenic Microenvironments with a Double-Network Composite Hydrogel for Bone Repair Open
The critical factor determining the in vivo effect of bone repair materials is the microenvironment, which greatly depends on their abilities to promote vascularization and bone formation. However, implant materials are far from ideal cand…
View article: Multifunctional Nanofibrous Scaffolds with Angle‐Ply Microstructure and Co‐Delivery Capacity Promote Partial Repair and Total Replacement of Intervertebral Disc (Adv. Healthcare Mater. 19/2022)
Multifunctional Nanofibrous Scaffolds with Angle‐Ply Microstructure and Co‐Delivery Capacity Promote Partial Repair and Total Replacement of Intervertebral Disc (Adv. Healthcare Mater. 19/2022) Open
Biomimetic Structures Annulus fibrosus (AF) repair is critical for treating disc herniation. In article 2200895, Fengxuan Han, Bin Li, and co-workers fabricate aligned core–shell nanofibrous scaffolds mimicking AF microstructure and realiz…
View article: The role of microenvironment in stem cell-based regeneration of intervertebral disc
The role of microenvironment in stem cell-based regeneration of intervertebral disc Open
Regenerative medicine for intervertebral disc (IVD) disease, by utilizing chondrocytes, IVD cells, and stem cells, has progressed to clinical trials in the treatment of back pain, and has been studied in various animal models of disc degen…
View article: A Multifunctional Composite Hydrogel That Rescues the ROS Microenvironment and Guides the Immune Response for Repair of Osteoporotic Bone Defects (Adv. Funct. Mater. 27/2022)
A Multifunctional Composite Hydrogel That Rescues the ROS Microenvironment and Guides the Immune Response for Repair of Osteoporotic Bone Defects (Adv. Funct. Mater. 27/2022) Open
Osteoporotic Defect Repair In article number 2201067, Chaoyong Liu, Bin Li, Fengxuan Han, and co-workers describe a multifunctional composite hydrogel approach, which enables effective repair of osteoporotic bone defects by rescuing the RO…
View article: TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair
TGF-β1-supplemented decellularized annulus fibrosus matrix hydrogels promote annulus fibrosus repair Open
Annulus fibrosus (AF) repair remains a challenge because of its limited self-healing ability. Endogenous repair strategies combining scaffolds and growth factors show great promise in AF repair. Although the unique and beneficial character…
View article: Role of oxygen migration on the thermal stability of the perpendicular magnetic anisotropy in bottom and top structures
Role of oxygen migration on the thermal stability of the perpendicular magnetic anisotropy in bottom and top structures Open
The effect of interfacial oxygen migration on the thermal stability of the perpendicular magnetic anisotropy (PMA) in bottom and top structures was investigated in detail. By controlling the diffusion of thermally activated oxygen atoms, P…
View article: Regulation of vascular branch formation in 3D bioprinted tissues using confining force
Regulation of vascular branch formation in 3D bioprinted tissues using confining force Open
The quality of the vascular network is key to the success of skin transplants. For skin grafts prepared using a tissue engineering approach, vascularization is a critical step determining tissue survival. Prevascularization of bioengineere…
View article: Bladder muscle regeneration enhanced by sustainable delivery of heparin from bilayer scaffolds carrying stem cells in a rat bladder partial cystectomy model
Bladder muscle regeneration enhanced by sustainable delivery of heparin from bilayer scaffolds carrying stem cells in a rat bladder partial cystectomy model Open
In bladder tissue engineering, regeneration of muscle is of equal importance to epithelial regeneration. However, as yet there is no effective strategy for promoting bladder muscle regeneration. In this study we aim to promote bladder musc…
View article: Effects of Ta and Pt/Ta Seed Layer on the Thermal Stability of CoFeB/MgO Perpendicular Magnetic Anisotropy Film
Effects of Ta and Pt/Ta Seed Layer on the Thermal Stability of CoFeB/MgO Perpendicular Magnetic Anisotropy Film Open
View article: <p>Enhanced Osseointegration of Titanium Implants by Surface Modification with Silicon-doped Titania Nanotubes</p>
Enhanced Osseointegration of Titanium Implants by Surface Modification with Silicon-doped Titania Nanotubes Open
The modification of Si-TiO2-NTs on the Ti substrate could generate a nanostructured and hydrophilic surface, which can promote cell growth. Moreover, the existence of the TiO2 nanotubes and Si element also can improve…
View article: Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia
Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia Open
Exploring innovative solutions to improve the healthcare of the aging and diseased population continues to be a global challenge. Among a number of strategies toward this goal, tissue engineering and regenerative medicine (TERM) has gradua…
View article: Helical Hydrogel Nanofibers: Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood‐Vessel‐on‐a‐Chip Applications (Adv. Healthcare Mater. 13/2019)
Helical Hydrogel Nanofibers: Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood‐Vessel‐on‐a‐Chip Applications (Adv. Healthcare Mater. 13/2019) Open
In article number 1900435 by Bin Li and co-workers, various complex helical structures and cell-laden hydrogel microfibers are fabricated using microfluidics-based technology. Human umbilical vein endothelial cells (HUVECs) can grow in the…