Fulin Xing
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View article: Super-resolution microscopy unveils the nanoscale organization and self-limiting clustering of CD47 in human erythrocytes
Super-resolution microscopy unveils the nanoscale organization and self-limiting clustering of CD47 in human erythrocytes Open
The transmembrane protein CD47, an innate immune checkpoint protein, plays a pivotal role in preventing healthy erythrocytes from immune clearance. Our study utilized stochastic optical reconstruction microscopy (STORM) and single-molecule…
View article: Single-cell manipulation by two-dimensional micropatterning
Single-cell manipulation by two-dimensional micropatterning Open
Cells are highly sensitive to their geometrical and mechanical microenvironment that directly regulate cell shape, cytoskeleton and organelle, as well as the nucleus morphology and genetic expression. The emerging two-dimensional micropatt…
View article: Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages (Adv. Sci. 23/2023)
Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages (Adv. Sci. 23/2023) Open
Mesenchymal Migration In article number 2301337, Fulin Xing, Leiting Pan, and co‐workers uncover an incomparable mobility of macrophages that they could migrate across non‐adhesive substrates in a mesenchymal mode on the adhesive‐nonadhesi…
View article: Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages
Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages Open
Mesenchymal migration usually happens on adhesive substrates, while cells adopt amoeboid migration on low/nonadhesive surfaces. Protein‐repelling reagents, e.g., poly(ethylene) glycol (PEG), are routinely employed to resist cell adhering a…
View article: Molecular Resolution Mapping of Erythrocyte Cytoskeleton by Ultrastructure Expansion Single‐Molecule Localization Microscopy
Molecular Resolution Mapping of Erythrocyte Cytoskeleton by Ultrastructure Expansion Single‐Molecule Localization Microscopy Open
The combination of expansion microscopy and single‐molecule localization microscopy has the potential to approach the molecular resolution. However, this combination meets challenges due to the hydrogel shrinkage in the presence of imaging…
View article: Regulation of actin cytoskeleton via photolithographic micropatterning
Regulation of actin cytoskeleton via photolithographic micropatterning Open
Actin cytoskeleton plays crucial roles in various cellular functions. Extracellular matrix (ECM) can modulate cell morphology by remodeling the internal cytoskeleton. To define how geometry of ECM regulates the organization of actin cytosk…
View article: Macrophage migrates on alternate non-adhesive surfaces
Macrophage migrates on alternate non-adhesive surfaces Open
Macrophages migrate across tissues upon immune demand, but their motility on heterogeneous substrates remains unclear. Protein-repelling reagents, e . g ., poly(ethylene) glycol (PEG), are routinely employed to resist cell adhering and mig…
View article: Regulation of intracellular Ca2+/CaMKII signaling by TRPV4 membrane translocation during osteoblastic differentiation
Regulation of intracellular Ca2+/CaMKII signaling by TRPV4 membrane translocation during osteoblastic differentiation Open
Bone constantly remodels between resorption by osteoclasts and formation by osteoblasts; therefore the functions of osteoblasts are pivotal for maintaining homeostasis of bone mass. Transient receptor potential vanilloid 4 (TRPV4), a type …
View article: Structural and functional studies of erythrocyte membrane-skeleton by single-cell and single-molecule techniques
Structural and functional studies of erythrocyte membrane-skeleton by single-cell and single-molecule techniques Open
As the indispensable oxygen-transporting cells, erythrocytes exhibit extreme deformability and amazing stability as they are subject to huge reversible shear stress and extrusion force during massive circulation in the body. The unique arc…
View article: Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia
Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia Open
Nerve injury is accompanied by a liberation of diverse nucleotides, some of which act as 'find/eat-me' signals in mediating neuron-glial interplay. Intercellular Ca2+ wave (ICW) communication is the main approach by which glial cells inter…
View article: [Ca<sup>2+</sup>]<sub>o</sub>-induced [Ca<sup>2+</sup>]<sub>c</sub> increase was blocked by 2-APB, BTP-2 and TMB-8 in rat calvarial osteoblasts, respectively.
[Ca<sup>2+</sup>]<sub>o</sub>-induced [Ca<sup>2+</sup>]<sub>c</sub> increase was blocked by 2-APB, BTP-2 and TMB-8 in rat calvarial osteoblasts, respectively. Open
(A) Typical tracings of [Ca2+]c responses resulted from elevating [Ca2+]o (10 mM) in the absence (control) and in the presence of 2-APB (25 µM), BTP-2 (20 µM), or TMB-8 (50 µM). Such reagents were added for 15 min before the elevation of […
View article: Rhein antagonizes P2X7 receptor in rat peritoneal macrophages
Rhein antagonizes P2X7 receptor in rat peritoneal macrophages Open
P2X 7 receptor plays important roles in inflammation and immunity and thereby it serves as a potential therapeutic target for inflammatory diseases. Rhein, an anthraquinone derivative, exhibits significant anti-inflammatory and immunosuppr…