Fumie Mitani
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View article: SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells
SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells Open
Extracellular vesicles (EVs) originating from intraluminal vesicles (ILVs) formed within multivesicular bodies (MVBs), often referred to as small EV (sEV) or exosomes, are aberrantly produced by cancer cells and regulate the tumor microenv…
View article: Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function
Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function Open
View article: MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function
MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function Open
Cancer cells secrete large amounts of extracellular vesicles (EVs) originating from multivesicular bodies (MVBs). Mature MVBs fuse either with the plasma membrane for release as EVs, often referred as to exosomes or with lysosomes for degr…
View article: c‐Src promotes tumor progression through downregulation of microRNA‐129‐1‐3p
c‐Src promotes tumor progression through downregulation of microRNA‐129‐1‐3p Open
MicroRNAs (miRNAs) fine‐tune cellular signaling by regulating expression of signaling proteins, and aberrant expression of miRNAs is observed in many cancers. The tyrosine kinase c‐Src is upregulated in various human cancers, but the molec…