Fumihiko Hirai
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View article: A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study
A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study Open
Background Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy. However, the clinical impact of…
View article: The clinical impact of concomitant medication use on the outcome of postoperative recurrent non-small-cell lung cancer in patients receiving immune checkpoint inhibitors
The clinical impact of concomitant medication use on the outcome of postoperative recurrent non-small-cell lung cancer in patients receiving immune checkpoint inhibitors Open
A recent study suggested that proton pump inhibitor (PPI) use in patients with advanced non-small-cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs) was associated with poor clinical outcomes. However, the clinical impa…
View article: Assessment of the albumin-bilirubin grade as a prognostic factor in patients with non-small-cell lung cancer receiving anti-PD-1-based therapy
Assessment of the albumin-bilirubin grade as a prognostic factor in patients with non-small-cell lung cancer receiving anti-PD-1-based therapy Open
The ALBI grade was an independent prognostic factor for survival in patients with advanced or recurrent NSCLC who receive anti-PD-1-based therapy. These findings should be validated in a prospective study with a larger sample size.
View article: Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy
Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy Open
Host immunonutritional status may have a significant effect on the postoperative prognosis of NSCLC in patients receiving APC.
View article: Clinical impact of probiotics on the efficacy of <scp>anti‐PD</scp>‐1 monotherapy in patients with nonsmall cell lung cancer: A multicenter retrospective survival analysis study with inverse probability of treatment weighting
Clinical impact of probiotics on the efficacy of <span>anti‐PD</span>‐1 monotherapy in patients with nonsmall cell lung cancer: A multicenter retrospective survival analysis study with inverse probability of treatment weighting Open
The gastrointestinal microbiota was reported as an important factor for the response to cancer immunotherapy. Probiotics associated with gastrointestinal dysbiosis and bacterial richness may affect the efficacy of cancer immunotherapy drug…
View article: Prognosis of Early-stage Part-solid and Pure-solid Lung Adenocarcinomas
Prognosis of Early-stage Part-solid and Pure-solid Lung Adenocarcinomas Open
Prognoses of PST and ST adenocarcinomas differ even when their solid component sizes are the same.
View article: A novel prognostic marker in patients with non-small cell lung cancer: musculo-immuno-nutritional score calculated by controlling nutritional status and creatine kinase
A novel prognostic marker in patients with non-small cell lung cancer: musculo-immuno-nutritional score calculated by controlling nutritional status and creatine kinase Open
The nutritional status combined with skeletal muscle index was suggested to provide more useful prognostic information than alone, which should be investigated in further prospective studies with a larger cohort.
View article: Phase I dose‐escalation study of capmatinib (<scp>INC</scp>280) in Japanese patients with advanced solid tumors
Phase I dose‐escalation study of capmatinib (<span>INC</span>280) in Japanese patients with advanced solid tumors Open
Capmatinib is a highly specific, potent and selective MET inhibitor. This was an open‐label, multicenter, dose‐escalation, phase I study conducted in Japanese patients with advanced solid tumors (not selected based on their MET status). Th…
View article: PD-L2 expression as a predictive biomarker for the response to anti-PD-1 drugs in non-small cell lung cancer patients
PD-L2 expression as a predictive biomarker for the response to anti-PD-1 drugs in non-small cell lung cancer patients Open
Objectives: The anti-programmed cell death-1 (PD-1) antibody downregulates the effector functions of T cells via PD-1 and programmed cell death-ligand 1 (PD-L1)/programmed cell death-ligand 2 (PD-L2) axis in the tumor microenvironment. The…
View article: PD-L2 Expression as a Potential Predictive Biomarker for the Response to Anti-PD-1 Drugs in Patients with Non-small Cell Lung Cancer
PD-L2 Expression as a Potential Predictive Biomarker for the Response to Anti-PD-1 Drugs in Patients with Non-small Cell Lung Cancer Open
PD-L2 expression may be a target of immunotherapy in patients with PD-L1-negative NSCLC.
View article: Prognostic Impact of PD-L2 Expression and Association with PD-L1 in Patients with Small-cell Lung Cancer
Prognostic Impact of PD-L2 Expression and Association with PD-L1 in Patients with Small-cell Lung Cancer Open
PD-L2 expression is not related to clinicopathological factors or postoperative prognosis in patients with SCLC, though this should be further investigated in studies involving larger populations.
View article: Phase II study of ceritinib in alectinib‐pretreated patients with anaplastic lymphoma kinase‐rearranged metastatic non‐small‐cell lung cancer in Japan: <scp>ASCEND</scp>‐9
Phase II study of ceritinib in alectinib‐pretreated patients with anaplastic lymphoma kinase‐rearranged metastatic non‐small‐cell lung cancer in Japan: <span>ASCEND</span>‐9 Open
Clinical experience of ceritinib in patients who progressed on alectinib is limited. In this prospective phase II study, we evaluated the activity of ceritinib in alectinib‐pretreated patients with anaplastic lymphoma kinase ( ALK )‐rearra…
View article: Radiological Features of Brain Metastases from Non-small Cell Lung Cancer Harboring<i>EGFR</i>Mutation
Radiological Features of Brain Metastases from Non-small Cell Lung Cancer Harboring<i>EGFR</i>Mutation Open
Careful follow-up of patients with EGFR-mutated NSCLC may be necessary given the high frequencies of multiple BMs and their location in the central area of the brain.
View article: Prevalence of Enhancer of Zeste Homolog 2 in Patients with Resected Small Cell Lung Cancer
Prevalence of Enhancer of Zeste Homolog 2 in Patients with Resected Small Cell Lung Cancer Open
EZH2 was frequently observed in patients with resected SCLC, but no significant associations were found between its expression and the clinicopathological characteristics and postoperative survivals.
View article: The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis
The significant influence of having children on the postoperative prognosis of patients with nonsmall cell lung cancer: A propensity score‐matched analysis Open
The aim of this study was to elucidate the relationship between family‐associated factors and the postoperative prognosis in patients with nonsmall cell lung cancer ( NSCLC ). Additionally, we investigated whether having children was assoc…
View article: Takotsubo Cardiomyopathy Developed After Two-stage Surgery for Double Primary Lung Cancer
Takotsubo Cardiomyopathy Developed After Two-stage Surgery for Double Primary Lung Cancer Open
Takotsubo cardiomyopathy (TC) is a syndrome characterized by transient local systolic dysfunction of the left ventricle with no evidence of coronary artery disease or acute plaque rupture. We present the case of 71-year-old woman who devel…
View article: Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review
Successful Treatment of Growing Teratoma Syndrome of the Lung by Surgical Resection: A Case Report and Literature Review Open
Growing teratoma syndrome (GTS) of the lung is extremely rare, and there are very few reports on this condition. This is a case report of GTS of the lung that was successfully treated by resection. A 19-year-old man, who had been diagnosed…
View article: A case of different EGFR mutations in surgically resected synchronous triple lung cancer
A case of different EGFR mutations in surgically resected synchronous triple lung cancer Open
We describe a 77-year-old Japanese woman who presented with three nodule shadows in three different lobes of the right lung, without evidence of lymph node metastasis or distant metastasis. All three tumors were surgically resected. The pa…
View article: High Frequency of Spread Through Air Spaces in Resected Small Cell Lung Cancer
High Frequency of Spread Through Air Spaces in Resected Small Cell Lung Cancer Open
STAS was frequently observed in patients with resected SCLC.
View article: Safety of Simultaneous Bilateral Pulmonary Resection for Metastatic Lung Tumors
Safety of Simultaneous Bilateral Pulmonary Resection for Metastatic Lung Tumors Open
One-stage bilateral pulmonary metastasectomy appears to be safe as long as only wedge resection is performed on at least one side.
View article: Which Primary Organ Is Most Suitable for Performing Pulmonary Metastasectomy?
Which Primary Organ Is Most Suitable for Performing Pulmonary Metastasectomy? Open
Colorectal carcinoma is associated with a greater survival benefit than cancer of other primary organs. Colorectal carcinoma cases should be more aggressively considered for MT than other primary organ cases.
View article: Clinical Significance of PD-L1 Expression in Brain Metastases from Non-small Cell Lung Cancer
Clinical Significance of PD-L1 Expression in Brain Metastases from Non-small Cell Lung Cancer Open
The PD-L1 expression in BM from NSCLC may be associated with local recurrence following surgery, and the smoking- or radiotherapy-derived effects.
View article: Radiological Features of Programmed Cell Death-Ligand 2-positive Lung Adenocarcinoma: A Single-institution Retrospective Study
Radiological Features of Programmed Cell Death-Ligand 2-positive Lung Adenocarcinoma: A Single-institution Retrospective Study Open
PD-L2-positive lung adenocarcinomas are less radiologically malignant and invasive than their PD-L1-positive counterparts.
View article: Association Between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer
Association Between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer Open
PD-L1 expression was related to high glucose metabolism in small-sized NSCLC.