Fumihiko Okumura
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View article: Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa
Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa Open
This study demonstrated that overexpression of the MexJK-OprM efflux pump is a key mechanism underlying TAZ/CTLZ resistance. In addition, prior administration of CAZ contributed to the acquisition of resistance, highlighting the need to co…
View article: Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
Spermidine reduces ISGylation and enhances ISG15–USP18 interaction Open
The expression of ubiquitin-like molecule interferon-stimulated gene 15 kDa (ISG15) and its post-translational modification (ISGylation) are significantly activated by interferons or pathogen infections, highlighting their roles in innate …
View article: Snf1 and yeast GSK3-β activates Tda1 to suppress glucose starvation signaling
Snf1 and yeast GSK3-β activates Tda1 to suppress glucose starvation signaling Open
View article: Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress
Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress Open
Deficiencies in mitochondrial protein import are associated with a number of diseases. However, although nonimported mitochondrial proteins are at great risk of aggregation, it remains largely unclear how their accumulation causes cell dys…
View article: Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation
Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation Open
The expression of the ubiquitin-like molecule interferon-stimulated gene 15 kDa (ISG15) and post-translational protein modification by ISG15 (ISGylation) are strongly activated by interferons or pathogen infection, suggesting that ISG15 an…
View article: Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions
Dot6/Tod6 degradation fine-tunes the repression of ribosome biogenesis under nutrient-limited conditions Open
View article: ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation
ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation Open
View article: Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding
Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding Open
View article: The C-terminal region of B-Myb interacts with HIF-2α.
The C-terminal region of B-Myb interacts with HIF-2α. Open
(A) Schematic representation of the B-Myb deletion mutants used in this study. (B) Co-immunoprecipitation between full-length HIF-2α and deletion mutants of B-Myb. Wild-type or deletion mutants of 3×HA-B-Myb were coexpressed with full leng…
View article: ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation Open
Proper dynamic regulation of the spindle is essential for successful cell division. However, the molecular mechanisms that regulate spindle dynamics in mitosis are not fully understood. In this study, we show that Cullin 5–interacting supp…
View article: The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle
The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle Open