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View article: A nomogram for predicting the risk of Clostridioides difficile infection in children with ulcerative colitis: development and validation
A nomogram for predicting the risk of Clostridioides difficile infection in children with ulcerative colitis: development and validation Open
Introduction This study aimed to develop a dynamic nomogram model to predict the risk of Clostridioides difficile infection (CDI) in children with ulcerative colitis (UC). Methods This was a retrospective study that clinical data from pedi…
View article: Crystal Form Investigation and Morphology Control of Salbutamol Sulfate via Spherulitic Growth
Crystal Form Investigation and Morphology Control of Salbutamol Sulfate via Spherulitic Growth Open
Salbutamol sulfate is a selective β2-receptor agonist used to treat asthma and chronic obstructive pulmonary disease. The crystals of salbutamol sulfate usually appear as needles with a relatively large aspect ratio, showing poor powder pr…
View article: Preliminary Study of Physiological Effects of Medical Tai Chi on the Cardiopulmonary System
Preliminary Study of Physiological Effects of Medical Tai Chi on the Cardiopulmonary System Open
In a preliminary study of the Physiological Effects of Medical Taiji on the Cardiopulmonary System an unusually high heart rate was observed in a single participant. Some key differences are observed between Taiji and conventional exercise…
View article: A Novel Supramolecular Salt of Hypoxanthine with Maleic Acid as a Potential Weight-Loss Drug
A Novel Supramolecular Salt of Hypoxanthine with Maleic Acid as a Potential Weight-Loss Drug Open
Improving the stability of drugs in the solid state, as well as improving their solubility and poor bioavailability, is highly physiologically relevant. In this study, we focused on enhancing the solubility of hypoxanthine (HYP) through sa…
View article: Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation
Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation Open
Axitinib (AXTN) is an oral tyrosine kinase inhibitor for the treatment of early to advanced renal cell carcinoma. In this work, solvates of AXTN were prepared in five solvents and subjected to desolvation treatment. The crystal form A of A…
View article: Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives
Prevention of Crystal Agglomeration: Mechanisms, Factors, and Impact of Additives Open
Crystal agglomeration is a common phenomenon for most chemicals and pharmaceuticals. The formation of agglomerates usually lowers product purity and generates a broad particle size distribution. This review focuses on preventing agglomerat…
View article: Effect of Additives on the Morphology of γ-Aminobutyric Acid Crystals
Effect of Additives on the Morphology of γ-Aminobutyric Acid Crystals Open
The effect of surfactant, polymer, and tailor-made additives on the crystallization of γ-aminobutyric acid (GABA) was studied in this work. Cooling crystallization of GABA in water yielded plate-like crystals. In the presence of sodium ste…
View article: Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents
Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents Open
The static gravimetric method was used to measure the solubility of 17-α hydroxyprogesterone (OHP) in 13 pure solvents ranging from 278.15 to 323.15 K. The results indicate that the experimental solubility of OHP increases with increasing …
View article: Determination and Correlation of Solubility of <i>N</i>-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K
Determination and Correlation of Solubility of <i>N</i>-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K Open
N-Acetylglucosamine (NAG) is a significant novel functional monosaccharide with a wide range of potential applications, such as in the medical and cosmetic fields. A gravimetric technique was used to assess the solubility of NAG in water, …
View article: The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome Open
Anemia is the most common manifestation in myelodysplastic syndrome (MDS) patients, but the cause of ineffective hematopoiesis is not fully understood. Enucleation is an important event in the maturation process of erythroblasts. According…
View article: Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K
Solubility Measurement and Correlation of Itraconazole Hydroxy Isobutyltriazolone in Four Kinds of Binary Solvent Mixtures with Temperature from 283.15 to 323.15 K Open
The solubility of itraconazole hydroxy isobutyltriazolone (IHI) in four commonly used binary solvent mixtures of N,N-dimethylformamide (DMF) + water, DMF + ethanol, tetrahydrofuran (THF) + water, and THF + ethanol was determined with gravi…
View article: Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives
Solubility and Crystallization of Glucosamine Hydrochloride in Water with the Presence of Additives Open
Glucosamine hydrochloride (GAH) is a kind of natural hexose, which is used to promote the synthesis of mucopolysaccharides and improve the metabolism of articular cartilage. In this paper, the solubility of GAH in pure water and aqueous sy…
View article: Hierarchical Structure of Glucosamine Hydrochloride Crystals in Antisolvent Crystallization
Hierarchical Structure of Glucosamine Hydrochloride Crystals in Antisolvent Crystallization Open
The crystal morphology of glucosamine hydrochloride (GAH) during antisolvent crystallization was investigated in this work. Particles of different shapes, such as plate-like crystals, leaflike clusters, fan-like dendrites, flower-like aggr…
View article: Refractive Index of 48 Neat Deep Eutectic Solvents and of Selected Mixtures: Effect of Temperature, Hydrogen-Bonding Donors, Hydrogen-Bonding Acceptors, Mole Ratio, and Water
Refractive Index of 48 Neat Deep Eutectic Solvents and of Selected Mixtures: Effect of Temperature, Hydrogen-Bonding Donors, Hydrogen-Bonding Acceptors, Mole Ratio, and Water Open
The refractive index (RI) is an important physiochemical property of deep eutectic solvents (DESs) for application in the optical identification of specific substances or measuring the concentration of solutes in solutions. However, the av…
View article: Polymer-mediated and ultrasound-assisted crystallization of ropivacaine: Crystal growth and morphology modulation
Polymer-mediated and ultrasound-assisted crystallization of ropivacaine: Crystal growth and morphology modulation Open
The objective of this research was to modify the crystal shape and size of poorly water-soluble drug ropivacaine, and to reveal the effects of polymeric additive and ultrasound on crystal nucleation and growth. Ropivacaine often grow as ne…
View article: Hot Water Extraction of Antioxidants from Tea Leaves—Optimization of Brewing Conditions for Preparing Antioxidant-Rich Tea Drinks
Hot Water Extraction of Antioxidants from Tea Leaves—Optimization of Brewing Conditions for Preparing Antioxidant-Rich Tea Drinks Open
There are billions of tea drinkers around the world. However, the optimized tea-brewing temperature and time conditions for achieving a higher concentration of antioxidants in tea drinks have not been thoroughly studied. Finding out the op…
View article: Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents Open
The solubility data of gliclazide in 10 mono-solvents (1,2-dichloroethane, 1,4-dioxane, 2-methoxyethanol, n-propyl acetate, isopropyl acetate, n-butyl acetate, pentyl acetate, dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), and 2-b…
View article: Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K
Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K Open
Metformin hydrochloride (MET·HCl) is one of the most widely used oral hypoglycemic drugs in the world. In addition to hypoglycemic effects, MET·HCl also has anti-inflammatory, anti-tumor, anti-aging, and other effects, showing good efficac…
View article: Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleation
Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleation Open
Enucleation is a key event in mammalian erythropoiesis responsible for the generation of enucleated reticulocytes. Although progress is being made in developing mechanistic understanding of enucleation, our understanding of mechanisms for …
View article: Subcritical Water Extraction of Natural Products
Subcritical Water Extraction of Natural Products Open
Subcritical water refers to high-temperature and high-pressure water. A unique and useful characteristic of subcritical water is that its polarity can be dramatically decreased with increasing temperature. Therefore, subcritical water can …
View article: Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride
Understanding the Reaction Crystallization Process of Glycidyl Trimethyl Ammonium Chloride Open
Reaction crystallization to produce glycidyl trimethyl ammonium chloride (GTA) via epichlorohydrin with gas-state trimethylamine was investigated. The crystallization process of the GTA gas-liquid reaction was optimized by a seed method. T…
View article: Application of PAT-Based Feedback Control Approaches in Pharmaceutical Crystallization
Application of PAT-Based Feedback Control Approaches in Pharmaceutical Crystallization Open
Crystallization is one of the important unit operations for the separation and purification of solid products in the chemical, pharmaceutical, and pesticide industries, especially for realizing high-end, high-value solid products. The prec…
View article: Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities
Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities Open
Deep eutectic solvents (DESs) play important roles in the extraction of active constituents in traditional Chinese medicine. Ultrasound-assisted DES has been used to extract flavonoids from Scutellaria baicalensis. Using the contents of sc…
View article: Comparison of the Extraction Efficiency of Isoflavone Compounds from <i>Puerariae lobatae</i> by Ionic Liquids with 11 Anions and 8 Imidazolium-Based Cations
Comparison of the Extraction Efficiency of Isoflavone Compounds from <i>Puerariae lobatae</i> by Ionic Liquids with 11 Anions and 8 Imidazolium-Based Cations Open
Although the field of natural product extraction with ionic liquids (ILs) is already a crowded one, the guiding rules regarding the selection of suitable ILs for extraction are still lacking. In this study, the extraction capacity of 32 IL…
Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes Open
Key Points TED is defective in patients with MDS. TED is an independent prognostic factor for survival in MDS.
View article: Extraction of isoflavones from <i>Puerariae lobata</i> using subcritical water
Extraction of isoflavones from <i>Puerariae lobata</i> using subcritical water Open
Four main isoflavones from Puerariae lobata were successfully extracted using subcritical water. Maximum yields of total isoflavones by response surface methodology were obtained.