Fuming Lei
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View article: 3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression
3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression Open
Colorectal carcinoma (CRC) is a deadly cancer with an aggressive nature, and how CRC tumor cells manage to translocate and proliferate in a new tissue environment remains not fully understood. Recently, higher-order chromatin structures an…
View article: 5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target
5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target Open
Metachronous liver metastases (MLM) are characterised by high incidence and high mortality in clinical colorectal cancer treatment. Currently traditional clinical methods cannot effectively predict and prevent the occurrence of metachronou…
View article: A recurrence‐predictive model based on eight genes and tumor mutational burden/microsatellite instability status in Stage <scp>II</scp>/<scp>III</scp> colorectal cancer
A recurrence‐predictive model based on eight genes and tumor mutational burden/microsatellite instability status in Stage <span>II</span>/<span>III</span> colorectal cancer Open
Background Although adjuvant chemotherapy (ACT) is widely used to treat patients with Stage II/III colorectal cancer (CRC), administering ACT to specific patients remains a challenge. The decision to ACT requires an accurate assessment of …
View article: 5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target
5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target Open
Metachronous liver metastases (MLM) are characterized by high incidence and high mortality in clinical colorectal cancer treatment. Currently traditional clinical methods cannot effectively predict and prevent the occurrence of metachronou…
View article: Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1
Rectal cancer-derived exosomes activate the nuclear factor kappa B pathway and lung fibroblasts by delivering integrin beta-1 Open
Numerous studies have revealed the importance of tumor-derived exosomes in rectal cancer (RC). This study aims to explore the influence of tumor-derived exosomal integrin beta-1 (ITGB1) on lung fibroblasts in RC along with underlying mecha…
View article: Development and validation of postoperative circulating tumor DNA combined with clinicopathological risk factors for recurrence prediction in patients with stages I-III colorectal cancer
Development and validation of postoperative circulating tumor DNA combined with clinicopathological risk factors for recurrence prediction in patients with stages I-III colorectal cancer Open
Background Circulating tumor DNA (ctDNA) detection following curative-intent surgery could directly reflect the presence of minimal residual disease, which is ultimately the cause of clinical recurrence. However, ctDNA is not postoperative…
View article: Comment on “Management and Outcome of Local Regrowths in a Watch-and-wait Prospective Cohort for Complete Responses in Rectal Cancer”
Comment on “Management and Outcome of Local Regrowths in a Watch-and-wait Prospective Cohort for Complete Responses in Rectal Cancer” Open
To the Editor: We read the article published in Annals of Surgery, titled "Management and Outcome of Local Regrowths in a Watch-and-wait Prospective Cohort for Complete Responses in Rectal Cancer."1 Beets et al explored the surgical treatm…
View article: Colorectal cancer and COVID‐19: Do we need to raise awareness and vigilance?
Colorectal cancer and COVID‐19: Do we need to raise awareness and vigilance? Open
We read with great interest the article by Zhang et al1 regarding the higher risk of coronavirus disease 2019 (COVID-19) in patients with cancer compared with patients without a cancer diagnosis. In their study, gastrointestinal cancer (20…
View article: Table of Contents
Table of Contents Open
The research on binocular ranging technology for transmission lines based
View article: Oncologists' Perspective: When Cancer Encounters COVID-19
Oncologists' Perspective: When Cancer Encounters COVID-19 Open
This Letter to the Editor adds to recent reports to provide guidance for cancer care during the COVID-19 pandemic.
View article: An enrichment model using regular health examination data for early detection of colorectal cancer
An enrichment model using regular health examination data for early detection of colorectal cancer Open
As an alternative approach for the early detection of CRC, this study provides a low-cost method using regular health examination data to identify high-risk individuals for CRC for further examinations. The approach can promote early detec…
View article: Case-matched study of short-term effects of 3D vs 2D laparoscopic radical resection of rectal cancer
Case-matched study of short-term effects of 3D vs 2D laparoscopic radical resection of rectal cancer Open
The 3D laparoscopy shortens the operation time of rectum cancer. 3D laparoscopic surgery is more efficient in treatment of rectal cancer than 2D laparoscopy and is worth of being generalized.
View article: A Case Report on Paraneoplastic Pemphigus Associated Colonic Carcinoma
A Case Report on Paraneoplastic Pemphigus Associated Colonic Carcinoma Open
Paraneoplastic pemphigus (PNP), an acantholytic mucocutaneous syndrome, has a universal association with malignancy and a poor prognosis.[1] The clinical picture is characterized by painful mucosal erosions, ulcerations, and polymorphous s…