Explanipedia

Hypothalamic–pituitary–adrenal dynamics in early-stage COVID-19 observed in a case with arginine vasopressin deficiency Open

Hinako Kirikae, Yuta Tezuka, Michiko Okamoto, Glenn T. Furuta, Kei Omata , et al. · 2025

These findings illustrate the rapid response of the HPA axis to inflammatory factors in the early-stage COVID-19, which may have important implications for understanding the initial host responses to SARS-CoV-2 infection.

Partial Pressure of Oxygen-Guided Adrenal Venous Sampling in Primary Aldosteronism Open

Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Hiromitsu Tannai, Hiroki Kamada , et al. · 2025

[Background] Primary aldosteronism (PA) is a leading cause of endocrine hypertension, characterized by the increased cardiovascular risks. Adrenal venous sampling (AVS) plays a pivotal role in optimization of treatment strategy for PA. How…

An Indolent Aldosterone-Producing Adenoma in a Young Hypertensive Patient Manifested during 7-Year Follow-up Open

Yuta Tezuka, Yoshikiyo Ono, Yuto Yamazaki, Satoshi Higuchi, Jun Nishikawa , et al. · 2025

Role of radiologists in the diagnosis and management of adrenal disorders Open

Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada , et al. · 2024

This study aimed to focus on the role of radiologists in the diagnosis and management of adrenal lesions, particularly primary aldosteronism (PA) and secondary hypertension. As hypertension affects more than one-third of the population in …

7676 Sex is An Influential Factor on the Conversion of Plasma Renin Activity and its Active Concentration Open

Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Fumitoshi Satoh · 2024

Disclosure: Y. Tezuka: None. K. Omata: None. Y. Ono: None. F. Satoh: None. Background: Renin is one of the essential factors to understand the cause of hypertension. In primary aldosteronism (PA), plasma renin activity (PRA) has been emplo…

Screening Cutoff Values for the Detection of Aldosterone-Producing Adenoma by LC-MS/MS and a Novel Noncompetitive CLEIA Open

Yoshikiyo Ono, Yuta Tezuka, Kei Omata, Ryo Morimoto, Yuto Yamazaki , et al. · 2024

Context Detecting patients with surgically curable aldosterone-producing adenoma (APA) among hypertensive individuals is clinically pivotal. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) is the ideal method of measuring plasma …

Subtype Identification of Surgically Curable Primary Aldosteronism During Treatment With Mineralocorticoid Receptor Blockade Open

Giovanni Pintus, Teresa Maria Seccia, Laurence Amar, Michel Azizi, Anna Riester , et al. · 2024

BACKGROUND: Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hyp…

Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study Open

Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kengo Kambara, Hiroki Kamada , et al. · 2024

Multifocal, Asymmetric Bilateral Primary Aldosteronism Cannot be Excluded by Strong Adrenal Vein Sampling Lateralization: An International Retrospective Cohort Study Open

Adina F. Turcu, Yuta Tezuka, Jung Soo Lim, Zara Salman, Kartik Sehgal , et al. · 2024

BACKGROUND: Primary aldosteronism (PA) has been broadly dichotomized into unilateral and bilateral forms. Adrenal vein sampling (AVS) lateralization indices (LI) ≥2 to 4 are the standard-of-care to recommend unilateral adrenalectomy for pr…

Identifying primary aldosteronism patients who require adrenal venous sampling: a multi-center study Open

Takumi Kitamoto, Tsuyoshi Idé, Yuta Tezuka, Norio Wada, Yui Shibayama , et al. · 2023

THU593 Unilaterally Selective Adrenal Vein Sampling For Identification Of Surgically Curable Primary Aldosteronism Open

Gian Paolo Rossi, Domenico Bagordo, Laurence Amar, Michel Azizi, Anna Riester , et al. · 2023

Disclosure: G. Rossi: None. D. Bagordo: None. L. Amar: None. M. Azizi: None. A. Riester: None. M. Reincke: None. C. Degenhart: None. J. Widimský: None. M. Naruse: None. J. Deinum: None. T. Kocjan: None. A. Negro: None. E. Rossi: None. G. K…

THU597 Po2-guided Adrenal Vein Sampling In Primary Aldosteronism Open

Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh · 2023

Disclosure: K. Omata: None. Y. Tezuka: None. Y. Ono: None. F. Satoh: None. Background: Accurate laterality diagnosis of adrenal aldosterone over-secretion is crucial in determining specific treatment for primary aldosteronism. Although adr…

THU595 New Screening Cutoff Values For Detection Of Aldosterone Producing Adenoma Examined By LC-MS/MS And Newly Developed Non-competitive Cleia Open

Fumitoshi Satoh, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Yuto Yamazaki , et al. · 2023

Disclosure: F. Satoh: None. Y. Ono: None. K. Omata: None. Y. Tezuka: None. Y. Yamazaki: None. H. Sasano: None. S. Kojima: None. Objective: Thinking of the poor accuracy of conventional CLEIA measurements of aldosterone, liquid chromatograp…

OR02-01 Somatic Mutations In The Zinc Transporter ZnT1 Cause Primary Aldosteronism Open

Juilee Rege, Sascha Bandulik, Kazutaka Nanba, Carla Kosmann, Amy Blinder , et al. · 2023

Disclosure: J. Rege: None. S. Bandulik: None. K. Nanba: None. C. Kosmann: None. A. Blinder: None. A. Plain: None. P. Vats: None. C. Kumar-Sinha: None. A.M. Lerario: None. T. Else: None. Y. Yamazaki: None. F. Satoh: None. H. Sasano: None. T…

Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production Open

Xilin Wu, Elena Azizan, Emily Goodchild, Sumedha Garg, Man Hagiyama , et al. · 2023

Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism Open

Juilee Rege, Sascha Bandulik, Kazutaka Nanba, Carla Kosmann, Amy Blinder , et al. · 2023

Supporting data for manuscript

Impact of Adrenalectomy on Diastolic Cardiac Dysfunction in Patients with Primary Aldosteronism Open

Kunihisa Nezu, Yoshihide Kawasaki, Ryo Morimoto, Yoshikiyo Ono, Kei Omata , et al. · 2022

Poor prognostic cardiac function is known among some patients with primary aldosteronism (PA). However, studies with echocardiograms on whether the normalization of aldosterone after laparoscopic adrenalectomy (LADX) improves myocardial hy…

Bipolar Radiofrequency Ablation of the Adrenal Gland: <i>In Vivo</i> and <i>Ex Vivo</i> Experiments Open

Tomo Kinoshita, Kazumasa Seiji, Sota Oguro, Yoshikiyo Ono, Ryo Morimoto , et al. · 2022

Laparoscopic adrenalectomy is currently the standard treatment modality for unilateral aldosterone-producing adenoma (APA); however, a less-invasive treatment is needed for its treatment. A new bipolar ablation system that poses a lower ri…

Marked reduction of proteinuria after removal of a growth hormone-producing pituitary adenoma in a patient with focal segmental glomerulosclerosis: a case report and literature review Open

Shizuka Ishigaki, Yuji Oe, Kei Omata, Yoshikiyo Ono, Yuta Tezuka , et al. · 2022

Development of IgG4-related Hypophysitis during Steroid Maintenance Therapy for Autoimmune Pancreatitis Open

Kensuke Daikoku, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto , et al. · 2022

67歳,男性.自己免疫性膵炎に対するステロイド維持療法中に視野障害,尿崩症が出現した.膵臓病変の増大はなかったが,血清IgG4(immunoglobulin G4)濃度は上昇しており,MRI(magnetic resonance imaging)での下垂体腫大と併せてIgG4関連下垂体炎と診断した.汎下垂体機能低下症も認め,高用量のステロイド治療を開始したところ,下垂体腫大は軽減し,視野障害の改善及び下垂体機能の部分的な回復が得られた.IgG4関連疾患は,維持療法中であって…

Zinc transporter somatic gene mutations cause primary aldosteronism Open

Juilee Rege, Kazutaka Nanba, Sascha Bandulik, Carla Kosmann, Amy Blinder , et al. · 2022

Primary aldosteronism (PA) is the most common form of endocrine hypertension and effects one in 50 adults. PA is characterized by inappropriately elevated aldosterone production via renin-independent mechanisms. Driver somatic mutations fo…

Safety and Feasibility of Radiofrequency Ablation Using Bipolar Electrodes for Aldosterone-Producing Adenoma: A Multicentric Prospective Clinical Study Open

Sota Oguro, Ryo Morimoto, Kazumasa Seiji, Hideki Ota, Tomo Kinoshita , et al. · 2022

Purpose: Evaluation of feasibility and safety of percutaneous radiofrequency ablation (RFA) using bipolar radiofrequency (RF) devices in a prospective multicenter cohort of patients with benign aldosterone-producing adenoma (APA). Methods:…

The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA) Open

Naoki Motomura, Yuto Yamazaki, Daiki Koga, Shogo Harashima, Xin Gao , et al. · 2022

Cortisol-producing adenoma (CPA) is composed of clear and compact cells. Clear cells are lipid abundant, and compact ones lipid poor but associated with higher production of steroid hormones. PRKACA mutation (PRKACA mt) in CPA patients was…

Laparoscopic Adrenalectomy Is Beneficial for the Health-Related Quality of Life of Older Patients with Primary Aldosteronism Open

Yoshihide Kawasaki, Shigeto Ishidoya, Ryo Morimoto, Yoshikiyo Ono, Kei Omata , et al. · 2021

Objective: Laparoscopic adrenalectomy (LADX) improves hypertension in patients with primary aldosteronism (PA). However, the antihypertensive impact of LADX appears restricted in older patients with PA. In this study, we evaluated the impa…

Comparison and commutability study between standardized liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and chemiluminescent enzyme immunoassay for aldosterone measurement in blood Open

Tetsuo Nishikawa, Fumitoshi Satoh, Yuichi Takashi, Toshihiko Yanase, Hiroshi Itoh , et al. · 2021

A commutability confirmation test for the blood aldosterone measurement was performed on liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) as a designated comparison method (DCM) and four chemiluminescent enzyme immunoas…

Renal Injuries in Primary Aldosteronism: Quantitative Histopathological Analysis of 19 Patients With Primary Adosteronism Open

Hiroko Ogata, Yuto Yamazaki, Yuta Tezuka, Xin Gao, Kei Omata , et al. · 2021

The rapid progression of chronic kidney disease and higher incidence of cardiovascular complications are well known in patients with hyperaldosteronism. However, detailed renal histopathologic characteristics of this disease have remained …

The Impact of ACTH on Peripheral Steroids Differs between Unilateral and Bilateral Primary Aldosteronism Open

Yuta Tezuka, Kae Ishii, Lili Zhao, Yuto Yamazaki, Ryo Morimoto , et al. · 2021

Background: ACTH is thought to contribute to aldosterone excess in primary aldosteronism (PA), possibly via aberrant melanocortin type 2 receptor (MC2R) expression in aldosterone producing adenomas (APAs). Dynamic manipulation of the hypot…

Intracellular Cholesterol Metabolism in Aldosterone-Producing Adenoma.~A Possible Association With Cellular Morphometry and Genotype~ Open

Shogo Harashima, Yuto Yamazaki, Yoshikiyo Ono, Kei Omata, Yuta Tezuka , et al. · 2021

Introduction: Primary aldosteronism (PA) is the most common cause of secondary hypertension. More than 70% of APAs have been reported to have KCNJ5 somatic mutation in Asian countiries. Patients with KCNJ5 mutated APAs generally harbor hig…

Visualization of Ca Channel Blocker on Human Adrenal Tissue by Mass Spectrometry Imaging ~Its Predominant Distribution at Aldosterone-Producing Cells ~ Open

Naoki Motomura, Yuto Yamazaki, Xin Gao, Yuta Tezuka, Kei Omata , et al. · 2021

Primary aldosteronism (PA) is the main cause of secondary hypertension, accounting for approximately 5–10% of all hypertension. Amlodipine, a third-generation calcium channel blocker, is one of the most frequently administered pharmaceutic…

Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review Open

Yuta Tezuka, Yuto Yamazaki, Yasuhiro Nakamura, Hironobu Sasano, Fumitoshi Satoh · 2021

For the last seven decades, primary aldosteronism (PA) has been gradually recognized as a leading cause of secondary hypertension harboring increased risks of cardiovascular incidents compared to essential hypertension. Clinically, PA cons…

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