Fumiya Yamaide
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View article: Multicentre, prospective, single-arm, non-controlled, open-label trial to evaluate the safety and efficacy of live attenuated influenza vaccine in paediatric patients with atopic dermatitis undergoing dupilumab therapy: a protocol
Multicentre, prospective, single-arm, non-controlled, open-label trial to evaluate the safety and efficacy of live attenuated influenza vaccine in paediatric patients with atopic dermatitis undergoing dupilumab therapy: a protocol Open
Introduction Atopic dermatitis (AD) is a chronic inflammatory skin condition that impairs the quality of life of affected paediatric patients and their families. Dupilumab, an antagonist of the shared alpha chain subunit of the cytokines i…
View article: Highly-sensitive peptide array using peptides immobilized on microbeads: Application to cow's milk allergy analysis
Highly-sensitive peptide array using peptides immobilized on microbeads: Application to cow's milk allergy analysis Open
with peptide microarrays containing linear epitopes of allergenic proteins is expected to provide information on the clinical status of the patient, but peptide arrays are still limited to research use. We thus aimed at developing a simple…
View article: Spectral Power Analysis of Delta Waves in Neonatal Electroencephalography: A Tool for Assessing Brain Maturation and Injury
Spectral Power Analysis of Delta Waves in Neonatal Electroencephalography: A Tool for Assessing Brain Maturation and Injury Open
Recent advances in neonatal care have improved survival rates of preterm infants but highlighted the persistent challenge of neurological impairments. This study focuses on delta wave analysis in neonatal electroencephalography (EEG) as a …
View article: Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study
Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study Open
Rhinitis findings and nasal eosinophilia are useful auxiliary diagnostic items for pediatric PAR. Sensitization to HDM and nasal eosinophilia were the most influential factors associated with future PAR onset. A combination of these factor…
View article: Cord blood zonulin is associated with high-level sensitization to food allergen and food allergy development
Cord blood zonulin is associated with high-level sensitization to food allergen and food allergy development Open
View article: Efficacy and safety of nemolizumab in paediatric patients aged 6–12 years with atopic dermatitis with moderate-to-severe pruritus: results from a phase III, randomized, double-blind, placebo-controlled, multicentre study
Efficacy and safety of nemolizumab in paediatric patients aged 6–12 years with atopic dermatitis with moderate-to-severe pruritus: results from a phase III, randomized, double-blind, placebo-controlled, multicentre study Open
Background Atopic dermatitis (AD) is a chronic, inflammatory skin condition affecting up to one-quarter of children. Uncontrolled pruritus associated with childhood AD, and the accompanying scratching, negatively impacts quality of life (Q…
View article: The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset
The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset Open
Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases. However, little is known regarding its impact…
View article: Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study
Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study Open
cTARC was associated with the development of allergic diseases and allergen sensitization in early childhood. These results suggest that, infantile AD-mediated atopic march starts during fetal life, and this immune status is reflected in t…
View article: Comparison of 30 Cytokines in Human Breast Milk between 1989 and 2013 in Japan
Comparison of 30 Cytokines in Human Breast Milk between 1989 and 2013 in Japan Open
Milk cytokines play a vital role in mucosal immunity during infancy by supporting immune development and functions. Although the maternal background characteristics influence milk cytokines, changes in cytokine levels across generations re…
View article: Maternal and infant serum carotenoids are associated with infantile atopic dermatitis development
Maternal and infant serum carotenoids are associated with infantile atopic dermatitis development Open
Epidemiological studies have shown that eczema/atopic dermatitis (AD) in infancy is a risk for skin sensitization to allergens1 and allergic diseases development later in life.2 In mammals,3 carotenoids must be supplied via dietary intake …
View article: Low Levels of Carotenoids in Maternal Serum and Breast Milk Associate with the Development of Atopic Dermatitis in Infancy
Low Levels of Carotenoids in Maternal Serum and Breast Milk Associate with the Development of Atopic Dermatitis in Infancy Open
View article: Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020
Executive summary: Japanese pediatric guideline for the treatment and management of asthma (JPGL) 2020 Open
This article covers the salient and updated themes of the Japanese Pediatric Guidelines for the Treatment and Management of Asthma (JPGL) 2020 published by the Japanese Society of Pediatric Allergy and Clinical Immunology. In the 2020 guid…
View article: Increase in eosinophil-derived neurotoxin level in school children with allergic disease
Increase in eosinophil-derived neurotoxin level in school children with allergic disease Open
Background Eosinophils are major effector cells of allergic disease and excellent markers of eosinophilic inflammation. Accurate and reliable biomarkers are helpful in the diagnosis, treatment, and control of allergic disease. Objective Th…
View article: A 10-year-old girl with low-grade B cell lymphoma complicated by anti-nuclear matrix protein 2 autoantibody-positive juvenile dermatomyositis
A 10-year-old girl with low-grade B cell lymphoma complicated by anti-nuclear matrix protein 2 autoantibody-positive juvenile dermatomyositis Open
Dear Editor, Inflammatory myopathies are the largest group of potentially treatable myopathies [1]. JDM is the most common juvenile idiopathic inflammatory myopathy [2]. Anti-nuclear matrix protein 2 (NXP2) antibody comprises ∼20% of juven…
View article: Association of the Maternal Gut Microbiota/Metabolome with Cord Blood CCL17
Association of the Maternal Gut Microbiota/Metabolome with Cord Blood CCL17 Open
Chemokine (C-C motif) ligand 17 (CCL17) is a pro-allergic factor: high CCL17 levels in cord blood (CB) precede later allergic predisposition. Short-chain fatty acid (SCFA) treatment during pregnancy has been shown to protect mouse pups aga…
View article: Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s
Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s Open
View article: Commentary on Japanese Pediatric Guideline for The Treatment and Management of Asthma 2020 Chapter 2 Definition, Pathophysiology, Diagnosis, and Severity Classification of Childhood Asthma
Commentary on Japanese Pediatric Guideline for The Treatment and Management of Asthma 2020 Chapter 2 Definition, Pathophysiology, Diagnosis, and Severity Classification of Childhood Asthma Open
小児気管支喘息治療・管理ガイドライン（Japanese Pediatric Guideline for The Treatment and Management of Asthma：JPGL）2020 第2章では，小児気管支喘息の定義，病態生理，診断，重症度分類について記載している．今回の改訂では，小児気管支喘息の定義を見直すとともに，2型気道炎症に重点をおいた病態生理の記載，喘息の鑑別に関する図，鑑別で重要な声帯機能不全（Vocal cord dysfunction, V…
View article: Corrigendum to "Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort" [World Allergy Organ J 12/10 (2019) 100065]
Corrigendum to "Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort" [World Allergy Organ J 12/10 (2019) 100065] Open
View article: Serum Zonulin levels are higher in pediatric allergic patients than that in healthy children
Serum Zonulin levels are higher in pediatric allergic patients than that in healthy children Open
Zonulin, an epithelial tight-junction regulator, plays an important role in the regulation of epithelial barrier function and was reported to play a pathogenic role in such as celiac disease and other chronic inflammatory diseases. Allergi…
View article: Association of the maternal gut microbiota/metabolome with cord blood CCL17
Association of the maternal gut microbiota/metabolome with cord blood CCL17 Open
BACKGROUND: Chemokine (C-C motif) ligand 17 (CCL17; also known as thymus and activation-regulated chemokine or TARC) is a pro-allergic factor, and high CCL17 levels in cord blood (CB) precede the allergic predisposition later in life. Offs…
View article: <i>Staphylococcus</i> Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development
<i>Staphylococcus</i> Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development Open
Skin colonization at 6 months of age by S. aureus with functional Agr quorum sensing associates with later atopic dermatitis development in infants.
View article: Serum zonulin levels are higher in pediatric allergic patients than those in healthy children
Serum zonulin levels are higher in pediatric allergic patients than those in healthy children Open
To the Editor In allergic diseases, not only ‘allergic inflammation’, but also ‘epithelial barrier impairment’ play important roles in their development1. Allergen penetration through epithelium to the body is essential for allergen sensit…
View article: Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort Open
View article: Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy
Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy Open
Soluble CD14 (sCD14) is one of the immunomodulatory factors in breast milk (BM). Although it may be involved in the prevention of atopic symptoms and sensitization to both food and inhalant allergens, conflicting evidence exists concerning…
View article: Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ)
Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ) Open
The epidemiology, characteristics and predictors of JIA-U in Japan are described here for the first time. Although the prevalence of JIA-U in Japan is lower than in predominantly Caucasian cohorts, as reported from North America and Europe…
View article: Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial
Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial Open
Background: Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of…
View article: Supplementary Material for: Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial
Supplementary Material for: Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial Open
Background: Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests t…
View article: Early use of alendronate as a protective factor against the development of glucocorticoid-induced bone loss in childhood-onset rheumatic diseases: a cross-sectional study
Early use of alendronate as a protective factor against the development of glucocorticoid-induced bone loss in childhood-onset rheumatic diseases: a cross-sectional study Open
View article: TGF-β Concentration in Breast Milk is Associated With the Development of Eczema in Infants
TGF-β Concentration in Breast Milk is Associated With the Development of Eczema in Infants Open
Background: Transforming growth factor (TGF)-β in breast milk is crucial for mucosal immune system in the neonatal period. We hypothesized that the level of exposure to TGF-β from breast milk in the first month of life is related to…
View article: Additional file 3: of Early use of alendronate as a protective factor against the development of glucocorticoid-induced bone loss in childhood-onset rheumatic diseases: a cross-sectional study
Additional file 3: of Early use of alendronate as a protective factor against the development of glucocorticoid-induced bone loss in childhood-onset rheumatic diseases: a cross-sectional study Open
Table S3. The characteristics and outcomes of alendronate-treated patients with and without bone loss. (DOCX 26 kb)