Naotake Funamizu
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View article: Clinical significance of postoperative cardiothoracic ratio for postoperative pleural effusion following hepatectomy
Clinical significance of postoperative cardiothoracic ratio for postoperative pleural effusion following hepatectomy Open
We clarified risk factors for CR-POPE following hepatectomy. The occurrence of CR-POPE might be predictable from the CTR on POD1.
View article: Tirzepatide-induced weight loss and obstructive sleep apnea improvement in an adult with type 2 diabetes: A case report
Tirzepatide-induced weight loss and obstructive sleep apnea improvement in an adult with type 2 diabetes: A case report Open
Rationale: Managing type 2 diabetes mellitus (T2DM) in adults with severe obesity frequently coexists with obstructive sleep apnea (OSA), complicating metabolic control and quality of life. Real-world, objective monitoring–documented traje…
View article: Nutritional Status and Chemotherapy Completion in Resectable Pancreatic Cancer: A Narrative Review
Nutritional Status and Chemotherapy Completion in Resectable Pancreatic Cancer: A Narrative Review Open
In this review, we define “malnutrition” according to the Global Leadership Initiative on Malnutrition (GLIM) criteria (phenotypic and etiologic components) and “cachexia” as a multifactorial syndrome characterized by progressive skeletal …
View article: Long-term survival in a patient with postoperative pulmonary oligometastasis of pancreatic cancer treated with surgical resection and chemotherapy: A case report
Long-term survival in a patient with postoperative pulmonary oligometastasis of pancreatic cancer treated with surgical resection and chemotherapy: A case report Open
Rationale: Pancreatic cancer (PC) frequently recurs after curative surgery. Pulmonary metastases are uncommon but may indicate more indolent disease. The benefit of aggressive treatment in cases with minimal dissemination remains unclear. …
View article: Novel modified frailty index predicts completion of adjuvant chemotherapy in resectable pancreatic cancer in a dual center study
Novel modified frailty index predicts completion of adjuvant chemotherapy in resectable pancreatic cancer in a dual center study Open
This study demonstrates that the modified frailty index-6 (mFI-6) is a useful tool for predicting the completion of S-1 adjuvant chemotherapy (AC) and associated adverse events (AEs) in patients with pancreatic cancer (PC). mFI-6 is an ind…
View article: Postoperative Geriatric Nutritional Risk Index as a Determinant of Tolerance to S-1 Adjuvant Chemotherapy After Curative Surgery for Pancreatic Ductal Adenocarcinoma: A Cohort Study with External Validation
Postoperative Geriatric Nutritional Risk Index as a Determinant of Tolerance to S-1 Adjuvant Chemotherapy After Curative Surgery for Pancreatic Ductal Adenocarcinoma: A Cohort Study with External Validation Open
S-1 adjuvant chemotherapy (AC) is the standard treatment for pancreatic ductal adenocarcinoma (PDAC) after curative surgery in Japan. Our prior research suggested that a lower postoperative geriatric nutritional risk index (GNRI) predicts …
View article: Recurrent cholangitis due to an intrahepatic calculus caused by migrated coil for vascular embolization: A case report
Recurrent cholangitis due to an intrahepatic calculus caused by migrated coil for vascular embolization: A case report Open
Rationale: Pseudoaneurysm is a potential postoperative complication in hepatobiliary and pancreatic surgery, with catheter-based interventions being the first-line treatment. This study reviews the literature on potential secondary complic…
View article: Liver resection in patients with a history of local ablation for hepatocellular carcinoma has the risk of poor survival and serosal invasion
Liver resection in patients with a history of local ablation for hepatocellular carcinoma has the risk of poor survival and serosal invasion Open
Aim The aim was to evaluate the impact of previous local ablation (LA) on long‐term prognoses and tumor histopathological findings following hepatectomy for hepatocellular carcinoma (HCC). Methods This retrospective study used data from pa…
View article: A Case of a Young Adult with Multiple Intrahepatic Stones Diagnosed as Low Phospholipid-Associated Cholelithiasis Showing <i>ABCB4</i> Gene Mutation
A Case of a Young Adult with Multiple Intrahepatic Stones Diagnosed as Low Phospholipid-Associated Cholelithiasis Showing <i>ABCB4</i> Gene Mutation Open
View article: C-Reactive Protein-to-Albumin Ratio as a Predictive Indicator for Evaluating Tolerability in S-1 Adjuvant Chemotherapy after Curative Surgery for Pancreatic Cancer: An External Validation Cohort Study
C-Reactive Protein-to-Albumin Ratio as a Predictive Indicator for Evaluating Tolerability in S-1 Adjuvant Chemotherapy after Curative Surgery for Pancreatic Cancer: An External Validation Cohort Study Open
Background: S-1 in adjuvant chemotherapy (AC) administration after pancreatic cancer (PC) surgery has been standardized in Japan. The Ehime study confirmed that a postoperative higher C-reactive protein-to-albumin ratio (CAR) value predict…
View article: Laparoscopic liver resection for a patient of hepatocellular carcinoma with von Willebrand disease: a case report
Laparoscopic liver resection for a patient of hepatocellular carcinoma with von Willebrand disease: a case report Open
View article: A Rare Presentation of Lymph Node Metastasis of VIPoma After Three Years of Resection: A Case Report
A Rare Presentation of Lymph Node Metastasis of VIPoma After Three Years of Resection: A Case Report Open
Vasoactive intestinal peptide-producing tumor of the pancreas (VIPoma) is one of the rarer subtypes of neuroendocrine tumor (NET) of the pancreas. It usually represents intractable diarrhea, weight loss, and electrolyte abnormalities secon…
View article: Robot-assisted spleen-preserving distal pancreatectomy in a 14-year-old patient with solid pseudopapillary neoplasm
Robot-assisted spleen-preserving distal pancreatectomy in a 14-year-old patient with solid pseudopapillary neoplasm Open
Robotic pancreatic surgery in pediatric patients has been an area of debate due to safety and feasibility secondary to technical difficulties, such as decreased abdominal space and lack of experience. Herein, we report a 14-year-old male p…
View article: Clinical significance of postoperative cardiothoracic ratio for postoperative pleural effusion following hepatectomy
Clinical significance of postoperative cardiothoracic ratio for postoperative pleural effusion following hepatectomy Open
Background: Although several preoperative risk factors for postoperative pleural effusion (POPE) after hepatectomy have been reported, few postoperative predictors have been investigated. We aimed to examine risk factors for clinically rel…
View article: Dorsal approach in laparoscopic extended left hemi-hepatectomy: A case series
Dorsal approach in laparoscopic extended left hemi-hepatectomy: A case series Open
Rationale: The utility of the dorsal approach has been reported for laparoscopic left hemi-hepatectomy. Patient concerns: The aim of the present study is to show the usefulness of the dorsal approach for laparoscopic extended left-hemi-hep…
View article: Novel embryological classifications of hepatic arteries based on the relationship between aberrant right hepatic arteries and the middle hepatic artery: A retrospective study of contrast-enhanced computed tomography images
Novel embryological classifications of hepatic arteries based on the relationship between aberrant right hepatic arteries and the middle hepatic artery: A retrospective study of contrast-enhanced computed tomography images Open
Background Variations in hepatic arteries are frequently encountered during pancreatoduodenecomy. Identifying anomalies, especially the problematic aberrant right hepatic artery (aRHA), is crucial to preventing vascular-related complicatio…
View article: C-Reactive Protein-to-Albumin Ratio to Predict Tolerability of S-1 as an Adjuvant Chemotherapy in Pancreatic Cancer
C-Reactive Protein-to-Albumin Ratio to Predict Tolerability of S-1 as an Adjuvant Chemotherapy in Pancreatic Cancer Open
Adjuvant chemotherapy (AC) with S-1 after radical surgery for resectable pancreatic cancer (PC) has shown a significant survival advantage over surgery alone. Consequently, ensuring that patients receive a consistent, uninterrupted S-1 reg…
View article: A Case of Splenic Hairy Cell Leukemia Showing Splenic Mass-like Morphology
A Case of Splenic Hairy Cell Leukemia Showing Splenic Mass-like Morphology Open
View article: A Case of a Recurrent Pseudoaneurysm Following Hilar Cholangiocarcinoma Operation
A Case of a Recurrent Pseudoaneurysm Following Hilar Cholangiocarcinoma Operation Open
View article: Diagnostic value of quantification of cell‐free <scp>DNA</scp> for suspected gallbladder cancer
Diagnostic value of quantification of cell‐free <span>DNA</span> for suspected gallbladder cancer Open
Background and Aim An accurate preoperative diagnosis as the basis for deciding the most appropriate surgical procedure is essential for patients with suspected gallbladder cancer ( GBC ). The aim of this study was to investigate the usefu…
View article: Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study
Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study Open
Aim The albumin‐indocyanine green evaluation (ALICE) score is a useful predictor of post‐hepatectomy liver failure (PHLF); however, its usefulness in combination with future liver remnant (FLR), measured by 3‐D volumetry, has not been inve…
View article: Living Donor Liver Transplantation in Patients with Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibodies Using Preoperative Desensitization Therapy According to Intensity of Donor-Specific Antibodies: A Single-Center Study
Living Donor Liver Transplantation in Patients with Preformed Donor-Specific Anti-Human Leukocyte Antigen Antibodies Using Preoperative Desensitization Therapy According to Intensity of Donor-Specific Antibodies: A Single-Center Study Open
BACKGROUND: In liver transplantation (LT), preoperative desensitization therapy is considered necessary in patients positive for donor-specific anti-human leukocyte antigen antibodies (DSAs). However, the relationship between DSA intensity…
View article: The impact of cystic duct tube on the onset time of postoperative bile leakage after hepatectomy: A propensity score-matched analysis
The impact of cystic duct tube on the onset time of postoperative bile leakage after hepatectomy: A propensity score-matched analysis Open
C-tube drainage may reduce early-onset BL in cases having risk factors for BL. Conversely, since late-onset BL often occurs after C-tube removal, attention should be paid to those cases.
View article: Postoperative cardiothoracic ratio on the first postoperative day is a predictor of postoperative pleural effusion drainage following hepatectomy
Postoperative cardiothoracic ratio on the first postoperative day is a predictor of postoperative pleural effusion drainage following hepatectomy Open
Purpose Although several preoperative risk factors for postoperative pleural effusion (POPE) after hepatectomy have been reported, few postoperative predictors have been investigated. We aimed to examine risk factors for clinically relevan…
View article: Prognostic Role of the Intrahepatic Lymphatic System in Liver Cancer
Prognostic Role of the Intrahepatic Lymphatic System in Liver Cancer Open
Although several prognosticators, such as lymph node metastasis (LNM), were reported for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), the prognostic impact of intrahepatic lymphatic vessel invasion (LVI) in liv…
View article: Supplementary Information from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Supplementary Information from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 Open
Supplementary Materials and Methods and Supplementary Figure Legends
View article: Supplementary Tables S1-S9 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Supplementary Tables S1-S9 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 Open
Table S1. Characteristics of Patients' Population (Test cohort, N=69). Table S2. Characteristics of Patients' Population (Validation Cohort-1, N=41). Table S3. Characteristics of Patients' Population (Validation Cohort-2, N=64). Table S4. …
View article: Data from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Data from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 Open
Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed t…
View article: Supplementary Information from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Supplementary Information from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 Open
Supplementary Materials and Methods and Supplementary Figure Legends
View article: Supplementary Figure 1-12 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Supplementary Figure 1-12 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 Open
Figure S1. Validation of miRNA microarray data by qRT-PCR in the test cohort (n=69). Figure S2. MIF regulates miR-301b expression in human pancreatic cancer Figure S3. NR3C2 is a potential target of miR-301b. Figure S4. Endogenous NR3C2 ex…