Fuqiang Gao
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View article: Localization of Acoustic Emission Source in Rock Using SMIGWO Algorithm
Localization of Acoustic Emission Source in Rock Using SMIGWO Algorithm Open
The Grey Wolf Optimization (GWO) algorithm is acknowledged as an effective method for rock acoustic emission localization. However, the conventional GWO algorithm encounters challenges related to solution accuracy and convergence speed. To…
View article: Vascular endothelial growth factor and regional cerebral blood flow in early Alzheimer’s disease
Vascular endothelial growth factor and regional cerebral blood flow in early Alzheimer’s disease Open
This manuscript supports the findings from previous in vitro and in vivo Alzheimer’s disease (AD) studies where angiogenesis was associated with cerebral blood flow (CBF) changes. Using both neuroimaging and neurophysiology measures, this …
View article: Frontal White Matter Hyperintensity Burden Predicts Cognitive Response to NAC and Exercise in Vascular Mild Cognitive Impairment
Frontal White Matter Hyperintensity Burden Predicts Cognitive Response to NAC and Exercise in Vascular Mild Cognitive Impairment Open
View article: Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew
Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew Open
Background/Objectives: Military aviators can be exposed to extreme physiological stressors, including decompression stress, G-forces, as well as intermittent hypoxia and/or hyperoxia, which may contribute to neurobiological dysfunction/dam…
View article: <scp> segcsvd <sub>WMH</sub> </scp> : A Convolutional Neural Network‐Based Tool for Quantifying White Matter Hyperintensities in Heterogeneous Patient Cohorts
<span> segcsvd <sub>WMH</sub> </span> : A Convolutional Neural Network‐Based Tool for Quantifying White Matter Hyperintensities in Heterogeneous Patient Cohorts Open
White matter hyperintensities (WMH) of presumed vascular origin are a magnetic resonance imaging (MRI)‐based biomarker of cerebral small vessel disease (CSVD). WMH are associated with cognitive decline and increased risk of stroke and deme…
View article: White matter hyperintensities and Alzheimer’s disease susceptibility: a genome‐wide interaction study
White matter hyperintensities and Alzheimer’s disease susceptibility: a genome‐wide interaction study Open
Background White matter hyperintensities (WMH) are commonly observed on MRI in Alzheimer’s disease (AD), but the molecular pathways underlying their relationships with the ATN biomarkers remain unclear. The aim of this study was to identif…
View article: Effects of post-acute COVID-19 syndrome on cerebral white matter and emotional health among non-hospitalized individuals
Effects of post-acute COVID-19 syndrome on cerebral white matter and emotional health among non-hospitalized individuals Open
Introduction Post-acute COVID syndrome (PACS) is a growing concern, given its impact on mental health and quality of life. However, its effects on cerebral white matter remain poorly understood, particularly in non-hospitalized cohorts. Th…
View article: Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases
Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases Open
INTRODUCTION We investigated the effect of perivascular spaces (PVS) volume on speeded executive function (sEF), as mediated by white matter hyperintensities (WMH) volume and plasma glial fibrillary acidic protein (GFAP) in neurodegenerati…
View article: segcsvd<sub>WMH</sub>: A convolutional neural network-based tool for quantifying white matter hyperintensities in heterogeneous patient cohorts
segcsvd<sub>WMH</sub>: A convolutional neural network-based tool for quantifying white matter hyperintensities in heterogeneous patient cohorts Open
White matter hyperintensities (WMH) of presumed vascular origin are an MRI-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with accelerated cognitive decline and increased risk of stroke and dementia, and are co…
View article: Differential contributions of the hippocampal dentate gyrus and CA1 subfield to mnemonic discrimination
Differential contributions of the hippocampal dentate gyrus and CA1 subfield to mnemonic discrimination Open
Evidence suggests that individual hippocampal subfields are preferentially involved in various memory‐related processes. Here, we demonstrated dissociations in these memory processes in two unique individuals with near‐selective bilateral …
View article: MICROSTRUCTURAL CHANGES IN THE PENUMBRAS OF CEREBRAL SMALL VESSEL DISEASE LESIONS ARE ASSOCIATED WITH COGNITION AND SLEEP
MICROSTRUCTURAL CHANGES IN THE PENUMBRAS OF CEREBRAL SMALL VESSEL DISEASE LESIONS ARE ASSOCIATED WITH COGNITION AND SLEEP Open
View article: VENOUS COLLAGENOSIS, WHITE MATTER HYPERINTENSITY AND THE PERIVASCULAR SPACE
VENOUS COLLAGENOSIS, WHITE MATTER HYPERINTENSITY AND THE PERIVASCULAR SPACE Open
View article: Examining perivascular spaces (PVS) in cerebral small vessel disease (CSVD) using a novel T1- based automated PVS segmentation tool
Examining perivascular spaces (PVS) in cerebral small vessel disease (CSVD) using a novel T1- based automated PVS segmentation tool Open
Introduction: White matter hyperintensities (WMH) and MRI-visible perivascular spaces (PVS) are neuroimaging features of cerebral small vessel disease (CSVD). PVS are believed to play a role in cerebral metabolic waste clearance, particula…
View article: Associations between MRI-visible perivascular spaces, brain atrophy, white matter hyperintensities, and speeded executive function, in neurodegenerative and cerebrovascular diseases.
Associations between MRI-visible perivascular spaces, brain atrophy, white matter hyperintensities, and speeded executive function, in neurodegenerative and cerebrovascular diseases. Open
Introduction: MRI-visible perivascular spaces (PVS) are a neuroimaging feature of cerebral small vessel disease and are commonly observed in patients with cerebrovascular and neurodegenerative disease. However, it is unclear whether PVS bu…
View article: Free water levels in normal-appearing white matter predict vascular lesion progression in individuals with dementia
Free water levels in normal-appearing white matter predict vascular lesion progression in individuals with dementia Open
Introduction: Cerebral small vessel disease (SVD) is a common co-pathology in elderly and individuals with dementia. Neuroimaging markers of SVD include white matter hyperintensities (WMH) and MRI-visible perivascular spaces (PVS). However…
View article: Persistent post‐COVID headache is associated with suppression of scale‐free functional brain dynamics in non‐hospitalized individuals
Persistent post‐COVID headache is associated with suppression of scale‐free functional brain dynamics in non‐hospitalized individuals Open
Introduction Post‐acute coronavirus disease 2019 (COVID‐19) syndrome (PACS) is a growing concern, with headache being a particularly debilitating symptom with high prevalence. The long‐term effects of COVID‐19 and post‐COVID headache on br…
View article: White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases
White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases Open
Background Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contrib…
View article: Rare neurovascular genetic and imaging markers across neurodegenerative diseases
Rare neurovascular genetic and imaging markers across neurodegenerative diseases Open
INTRODUCTION Cerebral small vessel disease (SVD) is common in patients with cognitive impairment and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated the burden of magnetic resonance imaging (MRI)‐bas…
View article: Relationships between polymorphisms in <i>EPHX2, CYP2J2, CYP2C9</i>, and CYP2C8, white matter hyperintensities, and regional atrophy
Relationships between polymorphisms in <i>EPHX2, CYP2J2, CYP2C9</i>, and CYP2C8, white matter hyperintensities, and regional atrophy Open
Background White matter hyperintensities (WMH) of presumed vascular origin commonly coincide with neurodegeneration. Previous studies reported heterogeneous relationships between WMH and atrophy. Cytochrome P450s CYP2J2, CYP2C8, and CYP2C9…
View article: Feasibility of diffusion‐tensor and correlated diffusion imaging for studying white‐matter microstructural abnormalities: Application in <scp>COVID</scp>‐19
Feasibility of diffusion‐tensor and correlated diffusion imaging for studying white‐matter microstructural abnormalities: Application in <span>COVID</span>‐19 Open
There has been growing attention on the effect of COVID‐19 on white‐matter microstructure, especially among those that self‐isolated after being infected. There is also immense scientific interest and potential clinical utility to evaluate…
View article: Effects of post-acute COVID-19 syndrome on the functional brain networks of non-hospitalized individuals
Effects of post-acute COVID-19 syndrome on the functional brain networks of non-hospitalized individuals Open
Introduction The long-term impact of COVID-19 on brain function remains poorly understood, despite growing concern surrounding post-acute COVID-19 syndrome (PACS). The goal of this cross-sectional, observational study was to determine whet…
View article: Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke
Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke Open
Background Cerebral small vessel disease is associated with higher ratios of soluble‐epoxide hydrolase derived linoleic acid diols (12,13‐dihydroxyoctadecenoic acid [DiHOME] and 9,10‐DiHOME) to their parent epoxides (12(13)‐epoxyoctadeceno…
View article: <scp>MRI</scp> Assessment of Cerebral Blood Flow in Nonhospitalized Adults Who Self‐Isolated Due to <scp>COVID</scp>‐19
<span>MRI</span> Assessment of Cerebral Blood Flow in Nonhospitalized Adults Who Self‐Isolated Due to <span>COVID</span>‐19 Open
Background Neurological symptoms associated with coronavirus disease 2019 (COVID‐19), such as fatigue and smell/taste changes, persist beyond infection. However, little is known of brain physiology in the post‐COVID‐19 timeframe. Purpose T…
View article: White Matter Hyperintensities and Cortical Atrophy are associated with Neuropsychiatric Symptoms in Neurodegenerative and Cerebrovascular Diseases
White Matter Hyperintensities and Cortical Atrophy are associated with Neuropsychiatric Symptoms in Neurodegenerative and Cerebrovascular Diseases Open
Background: Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contri…
View article: Venous Collagenosis as Pathogenesis of White Matter Hyperintensity
Venous Collagenosis as Pathogenesis of White Matter Hyperintensity Open
Objective Periventricular white matter hyperintensities (pvWMHs) are commonly observed on MRI in older individuals and are associated with cognitive and motor decline. The etiology of pvWMH remains unknown. Venous collagenosis has been imp…
View article: Decreased cerebral blood flow in non-hospitalized adults who self-isolated due to COVID-19
Decreased cerebral blood flow in non-hospitalized adults who self-isolated due to COVID-19 Open
The long-term consequences of coronavirus disease 2019 (COVID-19) on brain physiology and function are not yet well understood. From the recently described NeuroCOVID-19 study, we examined cerebral blood flow (CBF) in 50 participants recru…
View article: Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases Open
View article: Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation
Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation Open
White matter hyperintensities (WMHs) are frequently observed on structural neuroimaging of elderly populations and are associated with cognitive decline and increased risk of dementia. Many existing WMH segmentation algorithms produce subo…
View article: Brain structure and function in people recovering from COVID-19 after hospital discharge or self-isolation: a longitudinal observational study protocol
Brain structure and function in people recovering from COVID-19 after hospital discharge or self-isolation: a longitudinal observational study protocol Open
If neurophysiologic alterations are detected in the COVID-19 groups in our NeuroCOVID-19 study, this information could inform future research regarding interventions for long-haul COVID-19. The study results will be disseminated to scienti…
View article: Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation
Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation Open
White matter hyperintensities (WMH) are frequently observed on structural neuroimaging of elderly populations and are associated with cognitive decline and increased risk of dementia. Many existing WMH segmentation algorithms produce subop…