Explanipedia

Long-term outcomes of qing-dai-induced pulmonary arterial hypertension Open

Sarasa Isobe, Ly Tu, Yoshihiro Dohi, Takahiro Hiraide, Shiro Adachi , et al. · 2025

Background : Qing-Dai (indigo naturalis), which is used to treat inflammatory bowel disease in Japan, has been linked to pulmonary arterial hypertension (PAH) and is recognised by the European Society of Cardiology/European Respiratory Soc…

An on-chip deformability checker demonstrates that the severity of iron deficiency is associated with increased deformability of red blood cells Open

Kenji Kajitani, Tomohito Ohtani, Rie Higuchi, Misato Chimura, Fusako Sera , et al. · 2025

The deformability of red blood cells (RBCs) is essential for peripheral circulation and RBC survival and is reportedly altered in several diseases. However, its detail in iron-deficiency (ID) anemia remains poorly understood. We investigat…

Electron microscopic findings predict clinical outcomes in patients with non‐ischaemic cardiomyopathy Open

Rie Higuchi, Shozo Konishi, Tomohito Ohtani, Fusako Sera, Misato Chimura , et al. · 2025

Aims Electron microscopy reveals microstructural alterations in cardiomyocyte nuclei and myofilaments in non‐ischaemic cardiomyopathy (NICM), particularly in dilated cardiomyopathy (DCM). Nevertheless, the correlation between such observat…

Energy intake insufficiency due to underestimated energy requirement by common predictive formulas can be identified by urinary amino acid levels in advanced heart failure Open

Yoko Sakamoto, Tomohito Ohtani, Kei Nakamoto, Fusako Sera, Shungo Hikoso , et al. · 2025

Background Elevated resting energy expenditure (REE) promotes cachexia, worsening prognosis in patients with advanced heart failure (HF). However, adequate assessment of energy balance is challenging because of unvalidated common predictio…

Simple electrocardiographic index for A4-wave amplitude of the VDD leadless pacemaker Open

Takafumi Oka, Koki Tanabiki, Takayuki Sekihara, Akira Yoshida, Kentaro Ozu , et al. · 2025

Successful Hemostasis by Double-balloon Enteroscopy with Mini-laparotomy for Small-bowel Hemorrhage in a Patient with LVAD: A Case Report Open

Shun Sasaki, Yasuhiro Akazawa, Rennosuke Nakamoto, Ryotaro Uema, Takeo Yoshihara , et al. · 2025

A male patient in his 60s with advanced heart failure and a HeartMate3 left ventricular assist device (LVAD) was admitted to our hospital for the sixth time in one year due to recurrent small-bowel bleeding (SBB). Nine months after admissi…

Fulminant Cardiac Sarcoidosis Successfully Treated With Aggressive Immunosuppressive Therapy Open

Kaori Yasumura, Fusako Sera, Yasuhiro Akazawa, Kei Nakamoto, Makiko Kawai , et al. · 2025

Background: The clinical course of cardiac sarcoidosis is typically subacute, and fulminant cases requiring mechanical circulatory support are rare. Here, we report the case of a patient with pathologically diagnosed cardiac sarcoidosis wh…

A case report of pre-implantation feasibility test for combining leadless pacemaker and subcutaneous implantable cardioverter-defibrillator in adult congenital heart disease Open

Hibiki Mima, Takafumi Oka, Fusako Sera, Takayuki Sekihara, Kentaro Ozu , et al. · 2024

Correction: Novel indices representing heterogeneous distributions of myocardial perfusion imaging Open

Misato Chimura, Tomohito Ohtani, Fusako Sera, Rie Higuchi, Kenji Kajitani , et al. · 2024

Switching from Beraprost to Selexipag in the Treatment of Pulmonary Arterial Hypertension: Insights from a Phase IV Study of the Japanese Registry (The EXCEL Study: EXChange from bEraprost to seLexipag Study) Open

Yuichi Tamura, Hiraku Kumamaru, Ichizo Tsujino, Rika Suda, Kohtaro Abe , et al. · 2024

Pulmonary arterial hypertension (PAH) remains a significant challenge in cardiology, necessitating advancements in treatment strategies. This study explores the safety and efficacy of transitioning patients from beraprost to selexipag, a n…

Novel indices representing heterogeneous distributions of myocardial perfusion imaging Open

Misato Chimura, Tomohito Ohtani, Fusako Sera, Rie Higuchi, Kenji Kajitani , et al. · 2024

Diverse distribution patterns of segmental longitudinal strain are associated with different clinical features and outcomes in dilated cardiomyopathy Open

Kaoruko Sengoku, Tomohito Ohtani, Yasuharu Takeda, Toshinari Onishi, Fusako Sera , et al. · 2024

The WATCH-DM risk score estimates clinical outcomes in type 2 diabetic patients with heart failure with preserved ejection fraction Open

Katsuomi Iwakura, Toshinari Onishi, Atsunori Okamura, Yasushi Koyama, Nobuaki Tanaka , et al. · 2024

Novel indices representing heterogeneous distributions of myocardial perfusion imaging Open

Misato Chimura, Tomohito Ohtani, Fusako Sera, Rie Higuchi, Kenji Kajitani , et al. · 2024

Introduction Heterogeneous distribution in myocardial perfusion images (MPI) obtained by scintigraphy is often observed in cardiac diseases with normal myocardial perfusion. However, quantitative assessments of such heterogeneity have not …

Reliability of transient elastography as a noninvasive method for estimating central venous pressure in adult patients after a Fontan procedure Open

Misugi Emi, Fusako Sera, Yasumasa Tsukamoto, Yasuhiro Akazawa, Kei Nakamoto , et al. · 2023

In adult patients after a Fontan procedure, LS measured by TE showed a positive correlation with CVP by cardiac catheterization. TE can be useful as a noninvasive estimation of CVP.

Pectoralis muscle measures on preoperative computed tomography are strong predictors of early rehospitalization after left ventricular assist device implantation Open

Jun Tanabe, Yasuhiro Akazawa, Daisuke Nakamura, Kei Nakamoto, Fusako Sera , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Background/Introduction Skeletal muscle mass is reduced in severe heart failure and has a significantly impacts on subsequent outcomes and quality of life. The assessment of pectorali…

Pneumopericardium After the Removal of a Pericardiocentesis Drain Open

J. Tanabe, Hiraku Murakami, Yasuhiro Akazawa, Daisuke Nakamura, Fusako Sera , et al. · 2023

Pulmonary hypertension with a precapillary component in heart failure with preserved ejection fraction Open

Fusako Sera, Tomohito Ohtani, Shunsuke Tamaki, Masamichi Yano, Takaharu Hayashi , et al. · 2022

Objectives Heart failure with preserved ejection fraction (HFpEF) is often complicated by pulmonary hypertension (PH), which is mainly characterised by postcapillary PH and occasionally accompanied by a precapillary component of PH. Haemod…

Lowering Uric Acid May Improve Prognosis in Patients With Hyperuricemia and Heart Failure With Preserved Ejection Fraction Open

Masami Nishino, Yasuyuki Egami, Shodai Kawanami, Hiroki Sugae, Kohei Ukita , et al. · 2022

Background An association between uric acid (UA) and cardiovascular diseases, including heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF is controversial. In particular, the prognostic value of lowe…

Phospholamban p.Arg14del Cardiomyopathy: A Japanese Case Series Open

Tomoka Tabata, Yuki Kuramoto, Tomohito Ohtani, Hiroshi Miyawaki, Yohei Miyashita , et al. · 2021

Phospholamban p.Arg14del is reported to cause hereditary cardiomyopathy with malignant ventricular tachycardia (VT) and advanced heart failure. However, the clinical courses of Japanese cardiomyopathy patients with phospholamban p.Arg14del…

Renoprotection by long‐term low‐dose tolvaptan in patients with heart failure and hyponatremia Open

Tatsufumi Oka, Takayuki Hamano, Tomohito Ohtani, Yohei Doi, Karin Shimada , et al. · 2021

Aims In previous randomized controlled trials, the use of tolvaptan (TLV) at a fixed dose of 30 mg/day for 1 year did not provide renal benefits in patients with heart failure (HF). This retrospective, cohort study examined the renoprotect…

Variability in estimated glomerular filtration rate and patients' outcomes in a real‐world heart failure population Open

Tatsufumi Oka, Takayuki Hamano, Tomohito Ohtani, Akihiro Tanaka, Yohei Doi , et al. · 2021

Aims The prognostic significance of renal function variability has not been fully elucidated in heart failure (HF). This multicentre, prospective cohort study aimed to evaluate the usefulness of visit‐to‐visit variability in estimated glom…

Polycythemia Vera Associated with Pulmonary Hypertension and Diffuse Large B-Cell Lymphoma: A Case Report Open

Satoshi Kameda, Fusako Sera, Kazuaki Sato, Masako Kurashige, Shuichiro Higo , et al. · 2021

BACKGROUND Myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), are associated with pulmonary hypertension (PH) and malignant lymphomas. Although the underlying mechanisms have not been completely clarified, it has been s…

Pulmonary artery hypertension prior to the relapse of <span>adult‐onset</span> Still's disease Open

Yuki Hara, Takayoshi Morita, Katsunao Tanaka, Fusako Sera, Yasushi Sakata , et al. · 2021

Adult‐onset Still's disease (AOSD) is a rare inflammatory autoimmune disorder characterized by fever, skin rash, and arthralgia. Pulmonary artery hypertension (PAH) rarely occurs with AOSD and has not been reported in the absence of typica…

Feasibility of home-based cardiac rehabilitation using an integrated telerehabilitation platform in elderly patients with heart failure: A pilot study Open

Atsushi Kikuchi, Tatsunori Taniguchi, Kei Nakamoto, Fusako Sera, Tomohito Ohtani , et al. · 2021

Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure Open

Manabu Taneike, Makoto Nishida, Kaori Nakanishi, Fusako Sera, Hidetaka Kioka , et al. · 2021

Long-term outcomes of autologous skeletal myoblast cell-sheet transplantation for end-stage ischemic cardiomyopathy Open

Satoshi Kainuma, Shigeru Miyagawa, Köichi Toda, Yasushi Yoshikawa, Hiroki Hata , et al. · 2021

A Case of Lymphocytic Myocarditis with Eosinophilic Degranulation Successfully Treated with Steroid Therapy Open

Tomoko Inoue, Fusako Sera, Shunsuke Nishimura, Kei Nakamoto, Yasumasa Tsukamoto , et al. · 2020

A 49-year-old woman was admitted with suspicion of acute myocarditis. On the next day after admission, her serum troponin I level continued to rise, indicating progression of myocardial damage. Moreover, her symptoms persisted, and left ve…

Recovery From Exhaustion of the Frank-Starling Mechanism by Mechanical Unloading With a Continuous-Flow Ventricular Assist Device Open

Shunsuke Saito, Köichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata , et al. · 2020

The LVAD speed ramp and volume loading test facilitates the precise evaluation of native heart function during continuous-flow LVAD support.

Rapidly Progressive Heart Failure in a Female Carrier of Becker Muscular Dystrophy with No Skeletal Muscle Symptoms Open

Hirokazu Komoriyama, Arata Fukushima, Yumi Takahashi, Shintaro Kinugawa, Fusako Sera , et al. · 2019

Becker muscular dystrophy (BMD) carriers are at risk to developing cardiac dysfunction. The prevalence of female BMD carriers remains underestimated, and the disease progression varies. We herein report the case of a young female BMD carri…

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