Fushan Tang
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View article: Modified guchang decoction improves gut injury in Escherichia coli K88-challenged broilers by activating FXR and TGR5 signalling pathways
Modified guchang decoction improves gut injury in Escherichia coli K88-challenged broilers by activating FXR and TGR5 signalling pathways Open
View article: Relationship between psychological contract fulfillment, job burnout, and job satisfaction among pharmacists in private medical institutions in Guiyang, China
Relationship between psychological contract fulfillment, job burnout, and job satisfaction among pharmacists in private medical institutions in Guiyang, China Open
Objective This research aims to systematically investigate the mechanisms between psychological contract fulfillment and job burnout/job satisfaction among pharmacists, addressing the research gap in this population. Methods This is a cros…
View article: Integrating machine learning, docking analysis, molecular dynamics, and experimental validation for accelerated discovery of novel FLT3 inhibitors against AML
Integrating machine learning, docking analysis, molecular dynamics, and experimental validation for accelerated discovery of novel FLT3 inhibitors against AML Open
Acute myeloid leukemia (AML) is a malignant clonal disorder driven by the excessive proliferation of immature myeloid cells in the bone marrow and blood, often linked to Fms-like tyrosine kinase 3 ( FLT3 ) mutations, which occur in about o…
View article: The Impact of Hospital Pharmacists' Psychological Contracts on Medication Adherence Management: The Mediating Role of Job Burnout
The Impact of Hospital Pharmacists' Psychological Contracts on Medication Adherence Management: The Mediating Role of Job Burnout Open
(1) Background: This study examines the relationship between hospital pharmacists' psychological contracts and their attitudes and behaviors in managing patient medication adherence. The goal is to provide a solid scientific foundatio…
View article: Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances
Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances Open
In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional hydrogels face significant challenges in c…
View article: Tenofovir amibufenamide: A potential alternative for chronic hepatitis B treatment
Tenofovir amibufenamide: A potential alternative for chronic hepatitis B treatment Open
Tenofovir amibufenamide (TMF) is a novel prodrug of tenofovir that demonstrates a promising safety and efficacy profile. A recent study by Peng et al compared TMF with tenofovir alafenamide in the treatment of chronic hepatitis B. The find…
View article: Strengths, weaknesses, opportunities, and threats analysis of combination therapy for inflammatory bowel disease
Strengths, weaknesses, opportunities, and threats analysis of combination therapy for inflammatory bowel disease Open
Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, manifests as a chronic, recurrent, and refractory intestinal inflammatory condition significantly impacting patients’ quality of life. Despite ongoing r…
View article: Altered cognitive function in obese patients: relationship to gut flora
Altered cognitive function in obese patients: relationship to gut flora Open
View article: Gut microbiota and inflammasome-mediated pyroptosis: a bibliometric analysis from 2014 to 2023
Gut microbiota and inflammasome-mediated pyroptosis: a bibliometric analysis from 2014 to 2023 Open
Background The role of gut microbiota in inflammatory disease development and progression has been recognized more recently. Inflammasome-mediated pyroptosis in involved in these diseases. This complex relationship between gut microbiota a…
View article: Combined machine learning models, docking analysis, molecular dynamics and experimental validation for the rapid design of novel FLT3 inhibitors against AML
Combined machine learning models, docking analysis, molecular dynamics and experimental validation for the rapid design of novel FLT3 inhibitors against AML Open
Acute myeloid leukemia (AML) is a malignant clonal disorder driven by the excessive proliferation of immature myeloid cells in the bone marrow and blood, often linked to Fms-like tyrosine kinase 3 (FLT3) mutations, which occur in about one…
View article: Investigating influencing factors of medication adherence to inhalers in COPD patients: A study based on the Anderson model
Investigating influencing factors of medication adherence to inhalers in COPD patients: A study based on the Anderson model Open
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality globally, imposing significant economic burden due to treatment costs. Non-adherence to inhaler therapy is common among COPD patients, contributing to …
View article: <i>Helicobacter pylori</i>, esophageal precancerous lesions, and proton pump inhibitor overuse
<i>Helicobacter pylori</i>, esophageal precancerous lesions, and proton pump inhibitor overuse Open
This article reviews the cohort study published in the World Journal of Gastroenterology , which reported low rates of Helicobacter pylori (H. pylori ) infection among esophageal cancer (EC) patients, coupled with proton pump inhibitor (PP…
View article: Intensive care unit-acquired weakness: Unveiling significant risk factors and preemptive strategies through machine learning
Intensive care unit-acquired weakness: Unveiling significant risk factors and preemptive strategies through machine learning Open
This editorial discusses an article recently published in the World Journal of Clinical Cases , focusing on risk factors associated with intensive care unit-acquired weakness (ICU-AW). ICU-AW is a serious neuromuscular complication seen in…
View article: Elafibranor: A promising treatment for alcoholic liver disease, metabolic-associated fatty liver disease, and cholestatic liver disease
Elafibranor: A promising treatment for alcoholic liver disease, metabolic-associated fatty liver disease, and cholestatic liver disease Open
Liver diseases pose a significant threat to human health. Although effective therapeutic agents exist for some liver diseases, there remains a critical need for advancements in research to address the gaps in treatment options and improve …
View article: Study on influencing factors of medication adherence to inhalers in patients with COPD and asthma based on Anderson Model
Study on influencing factors of medication adherence to inhalers in patients with COPD and asthma based on Anderson Model Open
Purpose To investigate the influencing factors of adherence to inhalers in patients with COPD and asthma, providing reference for improving the adherence to inhalers of patients with asthma and COPD. Methods A questionnaire was designed ba…
View article: Avoiding misdiagnosis of multilocular thymic cysts as malignant tumors on computer tomography
Avoiding misdiagnosis of multilocular thymic cysts as malignant tumors on computer tomography Open
This editorial provides insights from a case report by Sun et al published in the World Journal of Clinical Cases . The case report focuses on a case where a multilocular thymic cyst (MTC) was misdiagnosed as a thymic tumor, resulting in a…
View article: Efficacy and safety of combinations of H<sub>1</sub> antihistamines in the treatment of urticaria: A scoping review
Efficacy and safety of combinations of H<sub>1</sub> antihistamines in the treatment of urticaria: A scoping review Open
The efficacy and safety of combining H 1 antihistamines (AHs) for treating urticaria are currently unclear. This scoping review aims to provide a comprehensive overview of the evidence regarding the efficacy and safety of H 1 AH combinatio…
View article: Emerging Insights into Postoperative Neurocognitive Disorders: The Role of Signaling Across the Gut-Brain Axis
Emerging Insights into Postoperative Neurocognitive Disorders: The Role of Signaling Across the Gut-Brain Axis Open
The pathophysiological regulatory mechanisms in postoperative neurocognitive disorders (PNCDs) are intricately complex. Currently, the pathogenesis of PNCDs has not been fully elucidated. The mechanism involved may include a variety of fac…
View article: Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells Open
Total saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and…
View article: Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis
Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis Open
The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis (PF), an irreversible lung injury. This condition can manifest within a short interval f…
View article: Professionals' Perspectives on Factors Influencing Adherence to Inhaler Medication in Patients with Copd and Asthma: A Qualitative Study
Professionals' Perspectives on Factors Influencing Adherence to Inhaler Medication in Patients with Copd and Asthma: A Qualitative Study Open
View article: Three-Dimensional Cell Co-Culture Liver Models and Their Applications in Pharmaceutical Research
Three-Dimensional Cell Co-Culture Liver Models and Their Applications in Pharmaceutical Research Open
As the primary site for the biotransformation of drugs, the liver is the most focused on organ type in pharmaceutical research. However, despite being widely used in pharmaceutical research, animal models have inherent species differences,…
View article: The Effect of Patients’ Psychological Contract with Pharmacists on Medication Adherence: A Qualitative Study
The Effect of Patients’ Psychological Contract with Pharmacists on Medication Adherence: A Qualitative Study Open
The psychological contract of outpatients with hospital pharmacists has a positive effect on their medication adherence. Effective management on medication adherence should involve the management on patients' psychological contract with ho…
View article: Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example
Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example Open
Ion-complementary self-assembling peptides have been studied in many fields for their distinct advantages, mainly due to their self-assembly properties. However, their shortcomings, such as insufficient specific activity and poor mechanica…
View article: Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-Ⅰ as an Example
Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-Ⅰ as an Example Open
Ion-complementary self-assembling peptides have been studied in many fields for their distinct advantages mainly due to their self-assembly properties. However, their shortcomings, such as insufficient specific activity and poor mechanical…
View article: Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair
Application of Hydrogels as Sustained-Release Drug Carriers in Bone Defect Repair Open
Large bone defects resulting from trauma, infection and tumors are usually difficult for the body’s repair mechanisms to heal spontaneously. Generally, various types of bones and orthopedic implants are adopted to enhance bone repair and r…
View article: Knowledge and Behavior in Rational Drug Use Among College Students in Zunyi City
Knowledge and Behavior in Rational Drug Use Among College Students in Zunyi City Open
Chengchen Yin,1– 3 Xing He,1– 3 Kaili Shen,1– 3 Xingrui Mu,1– 3 Fushan Tang1– 3 1Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, 563006, Peo…
View article: Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats
Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats Open
Xiaochaihu decoction is one of the most important traditional Chinese medicines that is widely used with other drugs in clinical practice, and may cause drug-drug interactions. However, there is not sufficient experimental evidence for the…
View article: Experimental anti-tumor effect of emodin in suspension – <i>in situ</i> hydrogels formed with self-assembling peptide
Experimental anti-tumor effect of emodin in suspension – <i>in situ</i> hydrogels formed with self-assembling peptide Open
Lung cancer is a major cause of cancer-related deaths worldwide. Stimulus-sensitive hydrogels, which can be formed by responding to stimuli in the cancer microenvironment, have been widely studied as controlled-release carriers for hydroph…
View article: Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo
Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo Open
Our results demonstrated that RADA16-I has the potential to be a carrier for the hydrophobic drug EM and can effectively improve the delivery of hydrophobic antitumor drugs with enhanced antitumor effects and reduced toxic effects of the d…