Fu‐Sheng Wang
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View article: IL-4R+SELL+ Naïve B Cell Expansion correlates with functional cure in PEG-IFNα Treated Chronic Hepatitis B Patients
IL-4R+SELL+ Naïve B Cell Expansion correlates with functional cure in PEG-IFNα Treated Chronic Hepatitis B Patients Open
During chronic hepatitis B (CHB) infection, B cell dysfunction is a key contributor to viral persistence. Pegylated interferon alpha (PEG-IFNα) acts as an effective therapeutic agent for CHB by restoring immune responses directed against H…
View article: Efficacy and safety of mesenchymal stem/stromal cells and their derived extracellular vesicles for acute respiratory distress syndrome: a systematic review and meta-analysis
Efficacy and safety of mesenchymal stem/stromal cells and their derived extracellular vesicles for acute respiratory distress syndrome: a systematic review and meta-analysis Open
View article: Impact on clinical biomarkers, immune recovery, and HIV reservoir dynamics of switching to EVG/c/FTC/TAF versus maintaining a non-INSTI-based regimen in virologically suppressed individuals
Impact on clinical biomarkers, immune recovery, and HIV reservoir dynamics of switching to EVG/c/FTC/TAF versus maintaining a non-INSTI-based regimen in virologically suppressed individuals Open
Background: Integrase Strand Transfer Inhibitors (INSTIs) have emerged as the preferred first-line antiretroviral therapy (ART) regimen globally, primarily due to their superior efficacy and favorable safety profile. However, in China, the…
View article: Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders
Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders Open
Disruption of the gut microenvironment is a hallmark of HIV infection, where regulatory T cells (Tregs) play a critical role in maintaining gut homeostasis. However, the mechanisms by which gut Tregs contribute to immune reconstitution fai…
View article: Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights
Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights Open
Decompensated liver cirrhosis (DLC) is characterized by severe liver dysfunction and immune dysregulation, posing significant treatment challenges. Mesenchymal stromal cell (MSC) therapy has shown promise in DLC treatment, but the optimal …
View article: Arthroscopic treatment of iliopsoas cyst using outside-in technique—surgical technique and clinical outcomes
Arthroscopic treatment of iliopsoas cyst using outside-in technique—surgical technique and clinical outcomes Open
Due to the low prevalence of iliopsoas cysts, as well as the technical challenges involved in locating cysts from outside the joint capsule during arthroscopic surgery, there is a lack of comprehensive arthroscopy technique and clinical li…
View article: Establishment and validation of a screening and risk predication model for rotator cuff tear and shoulder stiffness
Establishment and validation of a screening and risk predication model for rotator cuff tear and shoulder stiffness Open
Based on routine data, the prediction model offers clinicians a simple and reliable tool for predicting the combination of RCT and shoulder stiffness.
View article: Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8<sup>+</sup> T cells
Disruption of cell-intrinsic PCSK9 enhances the antitumor efficacy of CD8<sup>+</sup> T cells Open
Background Tumor-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) facilitates tumor progression, but the role of immune cell-intrinsic PCSK9 in tumor control remains unclear. Methods Orthotopic models of pancreatic cancer and …
View article: Significant Reduction of Chenodeoxycholic Acid and Glycochenodeoxycholic Acid in the Elderly with Severe COVID-19
Significant Reduction of Chenodeoxycholic Acid and Glycochenodeoxycholic Acid in the Elderly with Severe COVID-19 Open
Elderly individuals infected with SARS-CoV-2 are at higher risk of developing cytokine storms and severe outcomes, yet specific biomarkers remain unclear. In this study, we investigated the alteration of primary bile acid metabolism in eld…
View article: Evolution and characteristics of tetracycline resistance in <i>Mycoplasma pneumoniae</i>
Evolution and characteristics of tetracycline resistance in <i>Mycoplasma pneumoniae</i> Open
Macrolide resistance in Mycoplasma pneumoniae is becoming prevalent. Tetracyclines are an important alternative for patients with macrolide-resistant M. pneumoniae infections. Tetracycline-resistant M. pneumoniae has never been reported in…
View article: Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis
Antioxidant interventions reduced cytokine-induced pyroptosis of peripheral MAIT cells in patients with HBV-related cirrhosis Open
Background: Mucosal-associated invariant T (MAIT) cells are diminished in various liver diseases, but the underlying mechanism remains unclear. This study aimed to investigate the characteristics and underlying mechanisms of MAIT cell depl…
View article: PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub
PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub Open
Latent HIV-1 presents a formidable challenge for viral eradication. HIV-1 transcription and latency reversal require interactions between the viral promoter and host proteins. Here, we perform the dCas9-targeted locus-specific protein anal…
View article: <scp>CgABR1</scp>‐<scp><i>CgFAD</i></scp> negatively regulates the fruit neck length in citrus
<span>CgABR1</span>‐<span><i>CgFAD</i></span> negatively regulates the fruit neck length in citrus Open
Summary Pummelo ( Citrus maxima ) is a fundamental species of Citrus which contributes to most of the cultivated citrus, including sweet orange, lemon and etc. The fruit neck is a structural feature of pummelo, and a long fruit neck reduce…
View article: Early Immunological and Inflammation Proteomic Changes in Elderly COVID-19 Patients Predict Severe Disease Progression
Early Immunological and Inflammation Proteomic Changes in Elderly COVID-19 Patients Predict Severe Disease Progression Open
Background: Elderly patients infected with SARS-CoV-2 are at higher risk of developing cytokine storm and severe outcomes; however, specific immunological and proteomic biomarkers for early prediction remain unclear in this vulnerable grou…
View article: Viral persistence in long COVID: Research advances and treatment strategies
Viral persistence in long COVID: Research advances and treatment strategies Open
Although the coronavirus disease 2019 (COVID-19) pandemic has ended, the enduring health impacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continue to garner global attention, as approximately 10% of patient…
View article: Density‐Dependent Difference in Serum Levels of Immunoglobulin G in Brandt's Voles and Its Potential Influencing Factors
Density‐Dependent Difference in Serum Levels of Immunoglobulin G in Brandt's Voles and Its Potential Influencing Factors Open
Understanding the density‐dependent immune response is an important theme in ecological and evolutionary studies. Animals may elevate their immune response with an increase in population density. There is substantial evidence supporting th…
View article: Safety and efficacy of human umbilical cord-derived mesenchymal stem cells in COVID-19 patients: A real-world observation
Safety and efficacy of human umbilical cord-derived mesenchymal stem cells in COVID-19 patients: A real-world observation Open
Background: The effects of human umbilical cord-derived mesenchymal stem cell (UC-MSC) treatment on coronavirus disease 2019 (COVID-19) patients have been preliminarily characterized. However, real-world data on the safety and efficacy of …
View article: The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease
The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease Open
View article: Long-term outcomes of mesenchymal stem cell therapy in severe COVID-19 patients: 3-year follow-up of a randomized, double-blind, placebo-controlled trial
Long-term outcomes of mesenchymal stem cell therapy in severe COVID-19 patients: 3-year follow-up of a randomized, double-blind, placebo-controlled trial Open
ClinicalTrials.gov, NCT04288102. Registered 28 February 2020, https://clinicaltrials.gov/study/NCT04288102 .
View article: Aspergillus flavus arthritis of the knee misdiagnosed as septic arthritis: A case report
Aspergillus flavus arthritis of the knee misdiagnosed as septic arthritis: A case report Open
View article: Referee report. For: Seroconversion rates among different designs of COVID-19 vaccines: a network meta-analysis of randomized controlled trials [version 1; peer review: 2 approved with reservations]
Referee report. For: Seroconversion rates among different designs of COVID-19 vaccines: a network meta-analysis of randomized controlled trials [version 1; peer review: 2 approved with reservations] Open
View article: Early Alpha-Fetoprotein Response Predicts Sustained Tumor Response Following Immune Checkpoint Inhibitors Combined with Targeted Therapy in Liver Cancer
Early Alpha-Fetoprotein Response Predicts Sustained Tumor Response Following Immune Checkpoint Inhibitors Combined with Targeted Therapy in Liver Cancer Open
Background: Although immune checkpoint inhibitors (ICI) have revolutionized liver cancer treatment, some patients experience early tumor progression after therapy, missing the window for other potential treatments, such as neoadjuvant ther…
View article: New hope for cure of HIV-infected patients
New hope for cure of HIV-infected patients Open
View article: Theoretical and simulation analysis of DC bus current fluctuation control strategies of modular multilevel converter under AC side fault conditions
Theoretical and simulation analysis of DC bus current fluctuation control strategies of modular multilevel converter under AC side fault conditions Open
Modular Multilevel Converters (MMCs) play a crucial role in high-voltage DC (HVDC) systems due to their adaptable control and swift response capabilities. However, AC side faults could introduce asymmetric double-line frequency components …
View article: The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization Analysis
The Relationship between Smoking and Susceptibility to HIV Infection: A Two-Sample Mendelian Randomization Analysis Open
Smoking is prevalent among people living with the human immunodeficiency virus (HIV), and it increases morbidity and mortality in this population. However, due to ethical constraints, there is limited information on the effects of smoking …
View article: Implications of accumulation of clonally expanded and senescent CD4 <sup>+</sup> GNLY <sup>+</sup> T cells in immunological non-responders of HIV-1 infection
Implications of accumulation of clonally expanded and senescent CD4 <sup>+</sup> GNLY <sup>+</sup> T cells in immunological non-responders of HIV-1 infection Open
Increased CD4+GNLY+ T cells have been confirmed to be inversely associated with CD4+ T cell count in immunological non-responders (INRs), however, the underlying mechanisms are unknown. This study aimed to …
View article: Functional cure induced by tenofovir alafenamide plus peginterferon-alpha-2b in young children with chronic hepatitis B: a case series study
Functional cure induced by tenofovir alafenamide plus peginterferon-alpha-2b in young children with chronic hepatitis B: a case series study Open
TAF plus Peg-IFN-α-2b therapy is potentially safe and effective for pediatric CHB patients, which may provide important insights for future clinical practice and study designs targeting functional cures for children with CHB.
View article: Manipulating the 4-1BB Pathway to Cure HBV
Manipulating the 4-1BB Pathway to Cure HBV Open
Chronic Hepatitis B Virus (HBV) infection is a major global health issue leading to liver cirrhosis and hepatocellular carcinoma. Currently available treatments have limited efficacy in completely eradicating the virus.[1] The persistence …
View article: The effect of convalescent plasma therapy on the rate of nucleic acid negative conversion in patients with persistent COVID-19 test positivity
The effect of convalescent plasma therapy on the rate of nucleic acid negative conversion in patients with persistent COVID-19 test positivity Open
Objective This study investigates the association between convalescent plasma therapy and the negative conversion rate in patients with persistent COVID-19 test positivity. Method A retrospective analysis was conducted on patients with sev…
View article: Serum IP-10 increase correlated with PEG-IFNα response in nucleot(s)ide analogs-treated patients with chronic hepatitis B
Serum IP-10 increase correlated with PEG-IFNα response in nucleot(s)ide analogs-treated patients with chronic hepatitis B Open