Fuyi Liao
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View article: Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation
Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation Open
A greater understanding of chronic lung allograft dysfunction (CLAD) pathobiology, the primary cause of mortality after lung transplantation (LTx), is needed to improve outcomes. The complement system links innate to adaptive immune respon…
View article: Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages
Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages Open
Lung transplant survival is limited by the development of chronic lung allograft dysfunction (CLAD), a type of graft rejection that lacks effective treatments. Autophagy plays a crucial role in maintaining cellular homeostasis. In a single…
View article: <i>Pseudomonas aeruginosa</i> infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection
<i>Pseudomonas aeruginosa</i> infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection Open
How pathogens inhibit transplant tolerance remains unclear. Here, we found that Pseudomonas aeruginosa infection, but not other common bacterial respiratory infections, increases antibody-mediated rejection (AMR) risk in recipients of lung…
View article: Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation
Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation Open
A greater understanding of chronic lung allograft dysfunction (CLAD) pathobiology, the primary cause of mortality after lung transplantation, is needed to improve outcomes. The complement system links innate to adaptive immune responses an…
View article: Nanoparticle targeting of neutrophil glycolysis prevents lung ischemia-reperfusion injury
Nanoparticle targeting of neutrophil glycolysis prevents lung ischemia-reperfusion injury Open
View article: B cells mediate lung ischemia/reperfusion injury by recruiting classical monocytes via synergistic B cell receptor/TLR4 signaling
B cells mediate lung ischemia/reperfusion injury by recruiting classical monocytes via synergistic B cell receptor/TLR4 signaling Open
Ischemia/reperfusion injury-mediated (IRI-mediated) primary graft dysfunction (PGD) adversely affects both short- and long-term outcomes after lung transplantation, a procedure that remains the only treatment option for patients suffering …
View article: Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome
Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome Open
Bronchiolitis obliterans syndrome (BOS) is a major impediment to lung transplant survival and is generally resistant to medical therapy. Extracorporeal photophoresis (ECP) is an immunomodulatory therapy that shows promise in stabilizing BO…
View article: The role of neutrophil extracellular traps in acute lung injury
The role of neutrophil extracellular traps in acute lung injury Open
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high morbidity and mortality. Neutrophils play a key role in the development of different forms of ALI, and the release of neutrophil extracellular traps (NE…
View article: Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2<sup>+</sup> Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome
Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2<sup>+</sup> Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome Open
Bronchiolitis obliterans syndrome (BOS) is a major impediment to lung transplant survival and is generally resistant to medical therapy. Extracorporeal photophoresis (ECP) is an immunomodulatory therapy that shows promise in stabilizing BO…
View article: Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo
Galuminox: Preclinical validation of a novel PET tracer for non-invasive imaging of oxidative stress in vivo Open
View article: An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants
An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants Open
Obliterative bronchiolitis (OB) is a poorly understood airway disease characterized by the generation of fibrotic bronchiolar occlusions. In the lung transplant setting, OB is a pathological manifestation of bronchiolitis obliterans syndro…
View article: Mitochondrial damage–associated molecular patterns released by lung transplants are associated with primary graft dysfunction
Mitochondrial damage–associated molecular patterns released by lung transplants are associated with primary graft dysfunction Open
View article: Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance
Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance Open