Fuyuki Sato
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View article: Prognostic Significance of Tumor Budding in Early Oral Tongue Squamous Cell Carcinoma with Shallow Depth of Invasion
Prognostic Significance of Tumor Budding in Early Oral Tongue Squamous Cell Carcinoma with Shallow Depth of Invasion Open
Purpose This study aims to explore prognostic factors for late cervical lymph node metastasis in oral tongue squamous cell carcinoma (OTSCC) with pathological depth of invasion (pDOI) ≤ 3 mm, which, despite shallow invasion, may still be a…
View article: Subtraction <scp>CT</scp> Improves Detectability of Mandibular Bone Invasion in Oral Squamous Cell Carcinoma
Subtraction <span>CT</span> Improves Detectability of Mandibular Bone Invasion in Oral Squamous Cell Carcinoma Open
Objective Pretreatment evaluation of bone invasion in head and neck cancer is critical for treatment strategies. We investigated the usefulness of subtraction CT (SCT) in evaluating mandibular bone invasion in oral squamous cell carcinoma …
View article: Salvage skull base surgery after proton beam therapy for recurrent sinonasal malignancies: A retrospective study
Salvage skull base surgery after proton beam therapy for recurrent sinonasal malignancies: A retrospective study Open
Background This study aimed to examine treatment outcomes and postoperative complications associated with salvage skull base surgery following radical proton beam therapy (PBT). Methods Nine patients who underwent salvage skull base surger…
View article: Additional file 1 of Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Additional file 1 of Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder Open
Supplementary Material 1
View article: Clinicopathological Features of Buccal Squamous Cell Carcinoma with Focus on Patients Who Never Smoke and Never Drink
Clinicopathological Features of Buccal Squamous Cell Carcinoma with Focus on Patients Who Never Smoke and Never Drink Open
Introduction Oral carcinoma has been reported at a substantial proportion in patients who never smoke and never drink. However, the proportion may vary by subsite and ethnicity. Objective We aimed to determine the clinicopathological featu…
View article: Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder Open
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. Dec1, a BHLH transcription factor…
View article: High Speed Calculation Method Using Convolution for Calculating Normal and Disaster Costs of Buildings with Energy Generation and Storage Facilities
High Speed Calculation Method Using Convolution for Calculating Normal and Disaster Costs of Buildings with Energy Generation and Storage Facilities Open
In recent years, resilience-enhanced building buildings have been attracting increasing attention, in which photovoltaic (PV) power generation and storage batteries are installed in office buildings to continue operations even during a gri…
View article: <i>Smad3</i> deficiency accelerates tongue wound healing via epithelial cell-extracellular matrix interactions
<i>Smad3</i> deficiency accelerates tongue wound healing via epithelial cell-extracellular matrix interactions Open
Chieko Taguchi, Fuyuki Sato, Chen Wang, Shigeru Nakamura, Kosuke Oikawa, Ujjal Kumar Bhawal, Hiroyuki Okada, and Kazumune Arikawa. Oral Biol Res 2022;46:141-9. https://doi.org/10.21851/obr.46.04.202212.141
View article: Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer
Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer Open
Background Postoperative chemoradiotherapy (CRT) is a standard therapy for patients with high-risk factors for head and neck squamous cell carcinoma, including incomplete resection and extra-nodal extension (ENE). However, the prognostic i…
View article: Differential immunohistochemical expression of DEC1, CK‑1ε, and CD44 in oral atypical squamous epithelium and carcinoma <i>in situ</i>
Differential immunohistochemical expression of DEC1, CK‑1ε, and CD44 in oral atypical squamous epithelium and carcinoma <i>in situ</i> Open
Presence of nuclear atypia during histological investigation is often a cause of concern for pathologists while identifying tumor and non‑tumor cells in a biopsy sample of oral mucosa. Nuclear atypia is observed in severe inflammation, ulc…
View article: Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues
Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues Open
Sodium fluoride (NaF) is widely used in clinical dentistry. However, the administration of high or low concentrations of NaF has various functions in different tissues. Understanding the mechanisms of the different effects of NaF will help…
View article: The roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling
The roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling Open
The cold-shock protein Y-box-binding protein (YB)-1 regulates the expression of various chemokines and their receptors at the transcriptional level. Expression of the orphan chemokine CXCL14 is repressed by EGF induced signaling. The possi…
View article: The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation
The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation Open
Periodontal inflammation is a common inflammatory disease associated with chronic inflammation that can ultimately lead to alveolar attachment loss and bone destruction. Understanding autophagy and pyroptosis has suggested their significan…
View article: Complex Component of Oncocytic and Non-Oncocytic Lipoadenomas in the Parotid Gland: A Case Report
Complex Component of Oncocytic and Non-Oncocytic Lipoadenomas in the Parotid Gland: A Case Report Open
Oncocytic lipoadenoma of the salivary gland is a rare tumor that develops mainly in the parotid gland. We report a case of oncocytic lipoadenoma of the parotid gland in a 70-year-old woman. The tumor measured 30 × 20 mm and had a well-circ…
View article: <i>Dec2</i> attenuates autophagy in inflamed periodontal tissues
<i>Dec2</i> attenuates autophagy in inflamed periodontal tissues Open
Introduction Transcriptional regulation of autophagy depends on the transcription factors coordinated inflammatory feedback mechanism. Here, we provide a comprehensive functional characterization of periodontal ligament fibroblasts (PDLFs)…
View article: DEC1 negatively regulates AMPK activity via LKB1
DEC1 negatively regulates AMPK activity via LKB1 Open
Basic helix-loop-helix (bHLH) transcription factor DEC1 (bHLHE40/Stra13/Sharp2) is one of the clock genes that show a circadian rhythm in various tissues. AMP-activated protein kinase (AMPK) activity plays important roles in the metabolic …
View article: Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells
Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells Open
Myxoid liposarcoma (MLS) is thought to occur due to defective adipocytic differentiation in mesenchymal stem cells. A promising strategy for MLS treatment is the prevention of sarcomagenesis by promoting the terminal differentiation of MLS…
View article: MicroRNA 200b promotes mesenchymal‑to‑epithelial transition in anaplastic thyroid carcinoma
MicroRNA 200b promotes mesenchymal‑to‑epithelial transition in anaplastic thyroid carcinoma Open
Anaplastic thyroid cancer (ATC) remains a cancer with one of the worst prognoses, despite novel targeted therapies. The median survival rate has not improved for decades. Epithelial-to-mesenchymal transition (EMT) is a crucial step in phys…
View article: Alternation of Aggregate and Proliferation of Human Pancreatic Cancer Cells in Type I Collagen-coated and Fibronectin-coated Dishes
Alternation of Aggregate and Proliferation of Human Pancreatic Cancer Cells in Type I Collagen-coated and Fibronectin-coated Dishes Open
IntroductionCellular attachment to surfaces is highly influential in structural and functional characteristics of cells in culture.The interactions lead to activation of various intracellular signaling pathways that play an important role …
View article: Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis
Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis Open
Basic helix-loop-helix (BHLH) transcription factors differentiated embryonic chondrocyte gene 1 (DEC1) and gene 2 (DEC2) regulate circadian rhythms, apoptosis, epithelial mesenchymal transition (EMT), invasions and metastases in various ki…
View article: Dec1 Deficiency Suppresses Cardiac Perivascular Fibrosis Induced by Transverse Aortic Constriction
Dec1 Deficiency Suppresses Cardiac Perivascular Fibrosis Induced by Transverse Aortic Constriction Open
Cardiac fibrosis is a major cause of cardiac dysfunction in hypertrophic hearts. Differentiated embryonic chondrocyte gene 1 (Dec1), a basic helix–loop–helix transcription factor, has circadian expression in the heart; however, its role in…
View article: Differential expression of claudin‑4, occludin, SOX2 and proliferating cell nuclear antigen between basaloid squamous cell carcinoma and squamous cell carcinoma
Differential expression of claudin‑4, occludin, SOX2 and proliferating cell nuclear antigen between basaloid squamous cell carcinoma and squamous cell carcinoma Open
Basaloid squamous cell carcinomas (BSCCs) in oral lesions are extremely rare, and the histology is not well understood. Histologically, they are often similar to conventional squamous cell carcinoma (SCC). The present study was designed wi…