Arjun G. Yodh
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View article: Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring
Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring Open
The experiments demonstrate the equivalency of absolute flow measures from iDWS and DCS and improved precision of pulsatile waveforms from SCOS. These results emphasize the need for rapid development and adoption of iDWS and SCOS.
View article: Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans Open
Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the un…
View article: The fNIRS glossary project: a consensus-based resource for functional near-infrared spectroscopy terminology
The fNIRS glossary project: a consensus-based resource for functional near-infrared spectroscopy terminology Open
The fNIRS glossary provides a community-sourced resource that facilitates education and effective scientific communication within the fNIRS community and related fields. By lowering barriers to learning and engaging with fNIRS, the glossar…
View article: Pulse Oximetry: 50 Years of Inventions & Discoveries in Biomedical Optics
Pulse Oximetry: 50 Years of Inventions & Discoveries in Biomedical Optics Open
The editorial introduces the JBO Special Issue on Pulse Oximetry.
View article: Nucleation kinetics and virtual melting in shear-induced structural transitions
Nucleation kinetics and virtual melting in shear-induced structural transitions Open
Large shear deformations can induce structural changes within crystals, yet the microscopic kinetics underlying these transformations are difficult for experimental observation and theoretical understanding. Here, we drive shear-induced st…
View article: A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy
A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy Open
Photodynamic therapy (PDT) relies on the interactions between light, photosensitizers, and tissue oxygen to produce cytotoxic reactive oxygen species (ROS), primarily singlet oxygen (1O2) through Type II photochemical reactions, along with…
View article: The fNIRS Glossary Project: A Consensus-based Resource for Functional Near-Infrared Spectroscopy Terminology
The fNIRS Glossary Project: A Consensus-based Resource for Functional Near-Infrared Spectroscopy Terminology Open
Significance A shared understanding of terminology is essential for clear scientific communication and minimizing misconceptions. This is particularly challenging in rapidly expanding, interdisciplinary domains that utilize functional near…
View article: Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans Open
Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the un…
View article: Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements
Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements Open
Advanced optical neuromonitoring of cerebral hemodynamics with hybrid diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) methods holds promise for non-invasive characterization of brain health in critically ill p…
View article: Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol
Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol Open
Out-of-hospital cardiac arrest (OHCA) affects over 360,000 adults in the United States each year with a 50–80% mortality prior to reaching medical care. Despite aggressive supportive care and targeted temperature management (TTM), half of …
View article: Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver
Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver Open
This first in vivo validation of the Openwater optical system highlights its potential as a cerebral hemodynamic monitor, but additional validation is needed in disease states.
View article: Morphology and line tension of twist disclinations in a nematic liquid crystal
Morphology and line tension of twist disclinations in a nematic liquid crystal Open
This work characterizes twist disclinations in nematic liquid crystals, using confocal microscopy to measure their 3D profile and test theoretical predictions, and using magnetic fields to deform the disclinations and measure their line te…
View article: Portable Cerebral Blood Flow Monitor to Detect Large Vessel Occlusion in Suspected Stroke Patients
Portable Cerebral Blood Flow Monitor to Detect Large Vessel Occlusion in Suspected Stroke Patients Open
Background Early detection of large vessel occlusion (LVO) facilitates triage to a comprehensive or thrombectomy-capable stroke center to reduce treatment times and improve outcomes. Prehospital stroke scales, however, are not sufficiently…
View article: AAPM Task Group Report 311: Guidance for performance evaluation of fluorescence‐guided surgery systems
AAPM Task Group Report 311: Guidance for performance evaluation of fluorescence‐guided surgery systems Open
The last decade has seen a large growth in fluorescence‐guided surgery (FGS) imaging and interventions. With the increasing number of clinical specialties implementing FGS, the range of systems with radically different physical designs, im…
View article: Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability
Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability Open
Cardiopulmonary bypass (CPB) provides cerebral oxygenation and blood flow (CBF) during neonatal congenital heart surgery, but the impacts of CPB on brain oxygen supply and metabolic demands are generally unknown. To elucidate this physiolo…
View article: Abstract 001: Microvascular reperfusion during endovascular therapy: the balance of supply and demand
Abstract 001: Microvascular reperfusion during endovascular therapy: the balance of supply and demand Open
Introduction Endovascular therapy (EVT) has revolutionized acute stroke treatment, but large vessel recanalization does not always result in tissue‐level reperfusion. Cerebral blood flow (CBF) is not routinely monitored during EVT. Here we…
View article: Microvascular reperfusion during endovascular therapy: the balance of supply and demand
Microvascular reperfusion during endovascular therapy: the balance of supply and demand Open
Background Endovascular therapy (EVT) has revolutionized the treatment of acute stroke, but large vessel recanalization does not always result in tissue-level reperfusion. Cerebral blood flow (CBF) is not routinely monitored during EVT. We…
View article: Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath hold maneuver
Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath hold maneuver Open
Bedside cerebral blood flow (CBF) monitoring has the potential to inform and improve care for acute neurologic diseases, but technical challenges limit the use of existing techniques in clinical practice. Here we validate the Openwater opt…
View article: Direction-dependent dynamics of colloidal particle pairs and the Stokes-Einstein relation in quasi-two-dimensional fluids
Direction-dependent dynamics of colloidal particle pairs and the Stokes-Einstein relation in quasi-two-dimensional fluids Open
Hydrodynamic interactions are important for diverse fluids, especially those with low Reynolds number such as microbial and particle-laden suspensions, and proteins diffusing in membranes. Unfortunately, while far-field (asymptotic) hydrod…
View article: In situ observation of coalescence of nuclei in colloidal crystal-crystal transitions
In situ observation of coalescence of nuclei in colloidal crystal-crystal transitions Open
Coalescence of nuclei in phase transitions significantly influences the transition rate and the properties of product materials, but these processes occur rapidly and are difficult to observe at the microscopic scale. Here, we directly ima…
View article: The use of novel diffuse optical spectroscopies for improved neuromonitoring during neonatal cardiac surgery requiring antegrade cerebral perfusion
The use of novel diffuse optical spectroscopies for improved neuromonitoring during neonatal cardiac surgery requiring antegrade cerebral perfusion Open
Background Surgical procedures involving the aortic arch present unique challenges to maintaining cerebral perfusion, and optimal neuroprotective strategies to prevent neurological injury during such high-risk procedures are not completely…
View article: Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury
Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury Open
In this study, we used diffuse optics to address the need for non-invasive, continuous monitoring of cerebral physiology following traumatic brain injury (TBI). We combined frequency-domain and broadband diffuse optical spectroscopy with d…
View article: Data from Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging
Data from Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging Open
The prospective multicenter ACRIN 6691 trial was designed to evaluate whether changes from baseline to mid-therapy in a diffuse optical spectroscopic imaging (DOSI)–derived imaging endpoint, the tissue optical index (TOI), predict patholog…
View article: Supplementary Table S1 from Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging
Supplementary Table S1 from Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging Open
Accrual table by institution.
View article: Supplementary Table S1 from Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging
Supplementary Table S1 from Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging Open
Accrual table by institution.