Gary A. Boorman
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View article: Conflicts of interest in the International Agency for Research on Cancer process of identifying carcinogenic hazards to humans
Conflicts of interest in the International Agency for Research on Cancer process of identifying carcinogenic hazards to humans Open
Managing conflicts of interest (COIs) in scientific decision-making is important for minimizing bias and fostering public trust in science. Proper management of COIs has added significance when scientists are making decisions that impact p…
View article: Phenotypic Anchoring of Acetaminophen-Induced Oxidative Stress with Gene Expression Profiles in Rat Liver
Phenotypic Anchoring of Acetaminophen-Induced Oxidative Stress with Gene Expression Profiles in Rat Liver Open
Toxicogenomics provides the ability to examine in greater detail the underlying molecular events that precede and accompany toxicity, thus allowing prediction of adverse events at much earlier times compared to classical toxicological endp…
View article: Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis
Molecular Mechanisms of Fibrosis-Associated Promotion of Liver Carcinogenesis Open
Hepatocellular carcinoma (HCC) mostly develops in patients with advanced fibrosis; however, the mechanisms of interaction between a genotoxic insult and fibrogenesis are not well understood. This study tested a hypothesis that fibrosis pro…
View article: Acetaminophen-induced acute liver injury in HCV transgenic mice
Acetaminophen-induced acute liver injury in HCV transgenic mice Open
The exact etiology of clinical cases of acute liver failure is difficult to ascertain and it is likely that various co-morbidity factors play a role. For example, epidemiological evidence suggests that coexistent hepatitis C virus (HCV) in…
View article: Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice Open
Viral hepatitis and aflatoxin B1 (AFB1) exposure are common risk factors for hepatocellular carcinoma (HCC). The incidence of HCC in individuals co-exposed to hepatitis C (HCV) or B virus and AFB1 is greater than could be explained by the …
View article: Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype Open
This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (bloo…
View article: Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin
Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin Open
A 24-month oral carcinogenicity study of permethrin was conducted by feeding male and female CD-1 mice diets containing concentrations of 0, 20, 500, and 2,000 ppm of permethrin (males) or 0, 20, 2,500, and 5,000 ppm of permethrin (females…