Glen M. Boyle
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View article: A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma
A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma Open
Metastatic spread and therapeutic resistance are the principal causes of cancer mortality. For melanoma, these processes rely on the capacity of cells to switch between transcriptional states. Although targeting transcriptional states phar…
View article: Inhibition of BRN2 in Melanoma Reverses Anoikis Resistance and Sensitizes Cells to Killing by Vemurafenib
Inhibition of BRN2 in Melanoma Reverses Anoikis Resistance and Sensitizes Cells to Killing by Vemurafenib Open
Anoikis is an apoptotic cell death program triggered upon detachment from surrounding extracellular structures. However, the ability to evade cell death by anoikis in the presence of apoptosis-inducing stimuli is necessary for the formatio…
View article: Pathogenesis of polypropylene mesh complications in female pelvic floor surgery
Pathogenesis of polypropylene mesh complications in female pelvic floor surgery Open
Oxidation degradation was demonstrated equally in all cases and controls of polypropylene mesh explants. As such we were unable to confirm this was the cause of complications that were related to increased fibrosis and myofibroblast activi…
View article: Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal Adenocarcinomas
Spatial Transcriptomics Reveals Novel Mechanisms Involved in Perineural Invasion in Pancreatic Ductal Adenocarcinomas Open
Background: Pancreatic ductal adenocarcinoma (PDAC) has a high incidence of perineural invasion (PNI), a pathological feature of the cancer invasion of nerves. PNI is associated with a poor prognosis, local recurrence and cancer pain. It h…
View article: Spatial Transcriptomics of Perineural Invasion in Pancreatic Ductal Adenocarcinomas
Spatial Transcriptomics of Perineural Invasion in Pancreatic Ductal Adenocarcinomas Open
Pancreatic Ductal Adenocarcinoma (PDAC) has a high incidence of perineural invasion (PNI), a pathological feature of cancer invasion of nerves. PNI is associated with poor prognosis, metastasis, local recurrence and cancer pain. It has bee…
View article: Epoxytiglianes induce keratinocyte wound healing responses via classical protein kinase C activation to promote skin re-epithelialization
Epoxytiglianes induce keratinocyte wound healing responses via classical protein kinase C activation to promote skin re-epithelialization Open
Epoxytiglianes are a novel class of diterpene esters. The prototype epoxytigliane, EBC-46 (tigilanol tiglate), is a potent anti-cancer agent in clinical development for local treatment of a range of human and animal tumors. EBC-46 also con…
View article: Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade Open
Background Tigilanol tiglate (TT) is a protein kinase C (PKC)/C1 domain activator currently being developed as an intralesional agent for the treatment of various (sub)cutaneous malignancies. Previous work has shown that intratumoral (I.T.…
View article: 1091 Tigilanol Tiglate is a small molecule oncolytic that induces immunogenic cell death and promotes immune cell infiltration into human tumors
1091 Tigilanol Tiglate is a small molecule oncolytic that induces immunogenic cell death and promotes immune cell infiltration into human tumors Open
Background Tigilanol Tiglate (TT) is a novel small molecule under development for local treatment of solid tumours via intratumoral (I.T.) injection. TT is a protein kinase C (PKC)/C1 domain activator that disrupts tumour vasculature and c…
View article: Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck
Development of an in vivo murine model of perineural invasion and spread of cutaneous squamous cell carcinoma of the head and neck Open
Introduction Cutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This metastatic process is called perineural invasion (PNI) and spread (PNS). An …
View article: Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis
Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis Open
The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the extracellular matrix, is an absolute requirement for the survival of disseminating and circulating tumour cells (CTCs), and for the seeding of meta…
View article: Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens
Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens Open
Human skin needs additional protection from damaging ultraviolet radiation (UVR: 280–400 nm). Harmful UVR exposure leads to DNA damage and the development of skin cancer. Available sunscreens offer chemical protection from detrimental sun …
View article: Supplementary Table S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Supplementary Table S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome Open
Supplementary Table S1 (related to Fig. 4A): (A) Ingenuity Pathway Analysis derived from the uncorrected dataset displaying top canonical signaling pathways involving differentially regulated genes in recipients as described in Fig.4A. (B)…
View article: Supplementary Figure S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Supplementary Figure S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome Open
Supplementary Figure S1: GVHD survival of lethally-irradiated (day 0, 1000cGy split dose) B6.WT, B6.ASC-/- or B6.NLRP3-/- recipients transplanted with BALB/c BM (5x106) and T cells (5x106). The non-GVHD control group received TCD BM cells …
View article: Supplementary Table S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Supplementary Table S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome Open
Supplementary Table S1 (related to Fig. 4A): (A) Ingenuity Pathway Analysis derived from the uncorrected dataset displaying top canonical signaling pathways involving differentially regulated genes in recipients as described in Fig.4A. (B)…
View article: Data from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Data from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome Open
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein stru…
View article: Supplementary Figure S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Supplementary Figure S1 from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome Open
Supplementary Figure S1: GVHD survival of lethally-irradiated (day 0, 1000cGy split dose) B6.WT, B6.ASC-/- or B6.NLRP3-/- recipients transplanted with BALB/c BM (5x106) and T cells (5x106). The non-GVHD control group received TCD BM cells …
View article: Data from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome
Data from ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome Open
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein stru…
View article: Data from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma
Data from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma Open
STAT1 plays a pivotal role in signal transduction and transcriptional activation in response to type I and II IFNs. Regulation of STAT1 expression has significant consequences in human cancer cells, where STAT1 deficiencies have been assoc…
View article: Supplementary Figures 1 - 7, Tables 1 - 4 from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma
Supplementary Figures 1 - 7, Tables 1 - 4 from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma Open
PDF file - 675K, Supplementary Figure 1. Characterization of an ISRE in the human STAT1 gene promoter. Supplementary Figure 2. ChIP assay demonstrates binding of REST to the STAT1 RE-1 element in melanoma cell lines. Supplementary Figure 3…
View article: Supplementary Figures 1 - 7, Tables 1 - 4 from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma
Supplementary Figures 1 - 7, Tables 1 - 4 from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma Open
PDF file - 675K, Supplementary Figure 1. Characterization of an ISRE in the human STAT1 gene promoter. Supplementary Figure 2. ChIP assay demonstrates binding of REST to the STAT1 RE-1 element in melanoma cell lines. Supplementary Figure 3…
View article: Data from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma
Data from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma Open
STAT1 plays a pivotal role in signal transduction and transcriptional activation in response to type I and II IFNs. Regulation of STAT1 expression has significant consequences in human cancer cells, where STAT1 deficiencies have been assoc…
View article: Supplementary Figure Legend from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma
Supplementary Figure Legend from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma Open
PDF file - 167K
View article: Supplementary Figure Legend from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma
Supplementary Figure Legend from REST Negatively and ISGF3 Positively Regulate the Human <i>STAT1</i> Gene in Melanoma Open
PDF file - 167K
View article: Supplementary Figures S1-S6 from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Supplementary Figures S1-S6 from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis Open
This file contains Supplementary Figure S1A-B, Figure S2A, Figure S3-F, Figure S4A-B, Figure S5A-E and Figure S6A. Figure S1. CD73 expression in melanoma does not associate with survival. Figure S2. Hematopoietic A2AR-deficiency reduces in…
View article: Supplementary Methods, Table, and Legends from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Supplementary Methods, Table, and Legends from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis Open
This file contains Supplementary experimental Procedures, Supplementary Figure Legends, and Table S1. Table S1. Changes to patient CD73 expression following BRAF targeted therapy.
View article: Supplementary Methods, Table, and Legends from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Supplementary Methods, Table, and Legends from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis Open
This file contains Supplementary experimental Procedures, Supplementary Figure Legends, and Table S1. Table S1. Changes to patient CD73 expression following BRAF targeted therapy.
View article: Data from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Data from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis Open
Increasing evidence exists for the role of immunosuppressive adenosine in promoting tumor growth and spread in a number of cancer types, resulting in poor clinical outcomes. In this study, we assessed whether the CD73-adenosinergic pathway…
View article: Data from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Data from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis Open
Increasing evidence exists for the role of immunosuppressive adenosine in promoting tumor growth and spread in a number of cancer types, resulting in poor clinical outcomes. In this study, we assessed whether the CD73-adenosinergic pathway…
View article: Supplementary Figures S1-S6 from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Supplementary Figures S1-S6 from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis Open
This file contains Supplementary Figure S1A-B, Figure S2A, Figure S3-F, Figure S4A-B, Figure S5A-E and Figure S6A. Figure S1. CD73 expression in melanoma does not associate with survival. Figure S2. Hematopoietic A2AR-deficiency reduces in…