Clive Ballard
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View article: Discerning cognitive domains through online assessment in aging participants in Norwegian Cohort 50+
Discerning cognitive domains through online assessment in aging participants in Norwegian Cohort 50+ Open
Cognitive decline is a significant aspect of aging, varying across domains such as executive function, working memory, and attention. Identifying modifiable risk factors and their domain-specific effects is crucial to mitigating age-relate…
View article: Drug repurposing for Alzheimer’s disease: a Delphi consensus and stakeholder consultation
Drug repurposing for Alzheimer’s disease: a Delphi consensus and stakeholder consultation Open
View article: Alzheimer’s Disease blood biomarkers measured through remote capillary sampling correlate with cognitive performance in older adults
Alzheimer’s Disease blood biomarkers measured through remote capillary sampling correlate with cognitive performance in older adults Open
Blood biomarkers are rapidly becoming established in the diagnostic pathway for Alzheimer’s Disease (AD), particularly p-tau217. However, there is a need for more scalable detection tools to reach individuals who are not in contact with sp…
View article: Identifying synergistic combinations of repurposed treatments for Alzheimer’s Disease
Identifying synergistic combinations of repurposed treatments for Alzheimer’s Disease Open
View article: The computerised PROTECT Cognitive Test System is sensitive to dementia and correlates with Alzheimer-related blood biomarkers
The computerised PROTECT Cognitive Test System is sensitive to dementia and correlates with Alzheimer-related blood biomarkers Open
Early detection of cognitive impairment is essential for timely diagnosis and to support recruitment of pre-clinical patients into trials of disease-modifying therapies. Current clinically used tools have limited sensitivity for early cogn…
View article: Risk of stroke associated with risperidone in dementia with and without comorbid cardiovascular disease: population-based matched cohort study
Risk of stroke associated with risperidone in dementia with and without comorbid cardiovascular disease: population-based matched cohort study Open
Background Agitation and aggression occur in up to half of people living with dementia over the course of the disease. Although non-pharmacological interventions are used as first-line treatment strategies, antipsychotics may be indicated …
View article: The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-year Growth Mixture Model Analysis
The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-year Growth Mixture Model Analysis Open
Anxiety is common in autistic people, yet little is known about its course beyond midlife due to limited longitudinal research. We analysed data from 5,270 adults aged 50–91 (median 62; 75% female) in the PROTECT study. Participants comple…
View article: Social isolation and loneliness in adults over 50 with high autistic traits.
Social isolation and loneliness in adults over 50 with high autistic traits. Open
Social isolation and loneliness are major public health issues, especially in old age, with serious health impacts. Some populations, such as autistic people, have been found to report high rates of social isolation and loneliness compared…
View article: ASLEEP: Preventing and Treating Symptoms of Insomnia in Mid-Life and Older Adults – Study protocol for a Randomized Controlled Trial on the PROTECT Norge Infrastructure (Preprint)
ASLEEP: Preventing and Treating Symptoms of Insomnia in Mid-Life and Older Adults – Study protocol for a Randomized Controlled Trial on the PROTECT Norge Infrastructure (Preprint) Open
BACKGROUND Sleep is increasingly recognized as a fundamental determinant of health and brain function. Sleep difficulties are common in older adults, with a substantial proportion reporting problems initiating or maintaining sleep, which …
View article: Validation of the Care Partner Stress Scale in the CAN-PROTECT Study
Validation of the Care Partner Stress Scale in the CAN-PROTECT Study Open
Background Family and friend care partners play a vital role in supporting individuals with neurocognitive disorders, such as Alzheimer disease and related dementias. Care partners are often uncompensated and face unique, multifaceted chal…
View article: Validation of the Quality of Life and Function Five Domain Scale (QFS-5) against the EuroQol-5D (EQ-5D)
Validation of the Quality of Life and Function Five Domain Scale (QFS-5) against the EuroQol-5D (EQ-5D) Open
INTRODUCTION: Quality of life (QoL) captures objective life conditions, subjective wellbeing, and personal aspirations. There is growing interest in ability-based, patient-centred instruments that are not confounded by health outcomes. The…
View article: Treatment for Alzheimer's disease
Treatment for Alzheimer's disease Open
Over the last three decades, the evidence on how to best treat the cognitive and non-cognitive symptoms of patients with Alzheimer's disease has increased. Although these pharmacological and non-pharmacological strategies have significantl…
View article: Effects of Oral Anthocyanin Supplementation on In Vitro Neurogenesis, Hippocampus-Dependent Cognition, and Blood-Based Dementia Biomarkers: Results from a 24-Week Randomized Controlled Trial in Older Adults At Risk for Dementia (ACID)
Effects of Oral Anthocyanin Supplementation on In Vitro Neurogenesis, Hippocampus-Dependent Cognition, and Blood-Based Dementia Biomarkers: Results from a 24-Week Randomized Controlled Trial in Older Adults At Risk for Dementia (ACID) Open
Background: Identifying compounds with neuroprotective properties that target the neurogenic process will have a considerable impact on dementia prevention. Methods: This is a secondary analysis of a 24-week randomised, double-blind, place…
View article: Recommendations for management and future investigation of psychosis in neurodegenerative disease: Findings from the International Psychogeriatric Association (IPA) working group
Recommendations for management and future investigation of psychosis in neurodegenerative disease: Findings from the International Psychogeriatric Association (IPA) working group Open
Future directions include the need for the implementation of evidence-based nonpharmacological treatments consistent with the aims of precision medicine, further investigation into novel pharmacological agents, mapping specific psychotic s…
View article: Defining health and lifestyle characteristics of the age 50+ population: cluster analysis of data from the PROTECT study
Defining health and lifestyle characteristics of the age 50+ population: cluster analysis of data from the PROTECT study Open
Introduction The proportion of older people in the world is increasing and evidence suggests that older adults interact differently with products. Understanding this change is necessary to develop products that satisfy this cohort’s needs.…
View article: Brief operationalized psychosocial interventions for agitation and psychosis: Use in clinical trials and clinical care
Brief operationalized psychosocial interventions for agitation and psychosis: Use in clinical trials and clinical care Open
Although best practice guidelines universally recommend non-pharmacological interventions as the first-line treatment for neuropsychiatric symptoms, implementation has been limited. Several tools, such as Brief Psychosocial Therapy, are de…
View article: Autistic Traits and Suicidality in Midlife and Old Age: Investigating Mediating Effects of Mental Health and Social Connectedness
Autistic Traits and Suicidality in Midlife and Old Age: Investigating Mediating Effects of Mental Health and Social Connectedness Open
Aims: Suicidality is increased among middle-aged and older autistic adults; however, little is known about underlying factors linking Autism with suicidality in midlife and older age. This is the first study to address this. Methods: A cro…
View article: Clinical trials for neuropsychiatric syndromes in major and mild neurocognitive disorders: A CONSORT-based approach
Clinical trials for neuropsychiatric syndromes in major and mild neurocognitive disorders: A CONSORT-based approach Open
Neuropsychiatric syndromes (NPS) such as agitation, psychosis, apathy, and irritability are among the most disabling features of major and mild neurocognitive disorders including Alzheimer's disease, other neurodegenerative disorders (NDD)…
View article: Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial
Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial Open
Vitamin D supplementation produced no measurable improvement in cognitive outcomes in older adults with mild to moderate vitamin D deficiency. The remote trial methodology provides an innovative approach to large-scale trials.
View article: Web-Based Assessment of Cognition and Dementia Risk Factors in Over 3000 Norwegian Adults Aged 50 Years and Older: Cross-Sectional PROTECT Norge Study
Web-Based Assessment of Cognition and Dementia Risk Factors in Over 3000 Norwegian Adults Aged 50 Years and Older: Cross-Sectional PROTECT Norge Study Open
Background With the growing number of older adults in the Norwegian population and the associated rapid rise in dementia and cognitive impairment, novel and more efficient methodologies are needed to facilitate research, improve diagnostic…
View article: Drug Repositioning for Alzheimer’s Disease: A Delphi Consensus and Stakeholder Consultation
Drug Repositioning for Alzheimer’s Disease: A Delphi Consensus and Stakeholder Consultation Open
Background Alzheimer’s Disease (AD) is an escalating global challenge, with over 40 million people affected and this number is projected to increase to over 100 million by 2050. While amyloid-targeting antibody treatments (lecanumab and do…
View article: Pre-psychosis in later life as a risk factor for progressive cognitive decline: Findings from the IPA psychosis in neurodegenerative disease working group
Pre-psychosis in later life as a risk factor for progressive cognitive decline: Findings from the IPA psychosis in neurodegenerative disease working group Open
View article: Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti-inflammatory biomarker effects
Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti-inflammatory biomarker effects Open
Anthocyanins are dietary flavonoids shown to have a therapeutic capacity to mitigate inflammation and oxidative stress. The present secondary analyses from the “Anthocyanins in People at Risk for Dementia Study” were aimed at (I) determini…
View article: Clinical Evolution of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies in a Post‐Mortem Cohort
Clinical Evolution of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies in a Post‐Mortem Cohort Open
Background Almost all patients with neurodegenerative dementias experience neuropsychiatric symptoms (NPS) but the timing and clinical course is highly variable. Methods In a prospective cohort study in Western Norway, patients with a new …
View article: A Narrative Review of Alzheimer’s Disease and the Available Pharmaceuticals for Management of Its Cognitive Impairment in 2024
A Narrative Review of Alzheimer’s Disease and the Available Pharmaceuticals for Management of Its Cognitive Impairment in 2024 Open
Alzheimer’s disease is a neurodegenerative disorder characterized mainly by neurobehavioral changes that increase in severity over time. Research about this disease is paramount as the current understanding is that this disease will …
View article: Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study
Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study Open
Lewy body (LB) diseases are an umbrella term encompassing a range of neurodegenerative conditions all characterized by the hallmark of intra-neuronal α-synuclein associated with the development of motor and cognitive dysfunction. In this s…
View article: The Association Between Autism Spectrum Traits and Age-Related Spatial Working Memory Decline: A Large-Scale Longitudinal Study
The Association Between Autism Spectrum Traits and Age-Related Spatial Working Memory Decline: A Large-Scale Longitudinal Study Open
Background and Objectives Based on mixed findings from previous research, researchers have hypothesized autism may be a protective or risk factor for age-related cognitive decline/dementia, or that autism does not influence it (parallel ag…
View article: Blocking the Dkk1-LRP6 interaction prevents acute amyloid-β-driven cognitive impairment
Blocking the Dkk1-LRP6 interaction prevents acute amyloid-β-driven cognitive impairment Open
View article: Menopausal symptom burden as a predictor of mid- to late-life cognitive function and mild behavioral impairment symptoms: A CAN-PROTECT study
Menopausal symptom burden as a predictor of mid- to late-life cognitive function and mild behavioral impairment symptoms: A CAN-PROTECT study Open
Background Recent evidence suggests the experience of menopausal symptoms (i.e., perimenopausal symptoms) may be associated with cognitive and behavioural changes. We investigated these two relationships in a sample of postmenopausal femal…
View article: Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson’s Disease Psychosis
Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson’s Disease Psychosis Open
Background Cognitive deficits and reduced dopamine transporter (DAT) binding ratio have been reported in Parkinson’s disease psychosis (PDP). However, it remains unclear whether DAT striatal binding ratio (SBR) may contribute to worsening …