María G. Castro
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View article: Diagnostic accuracy of the novel and biosafe molecular assay Orange G3 TBC compared to GeneXpert for tuberculosis diagnosis in resource-limited settings
Diagnostic accuracy of the novel and biosafe molecular assay Orange G3 TBC compared to GeneXpert for tuberculosis diagnosis in resource-limited settings Open
Background: Tuberculosis (TB) remains a global public health priority, with 10.5 million new cases and 1.5 million deaths reported in 2023. Current diagnostic methods face limitations in sensitivity, biosafety, and accessibility, particula…
View article: Mental Health in Adolescence as a Mitigating Factor for Bruxism: Literature Review
Mental Health in Adolescence as a Mitigating Factor for Bruxism: Literature Review Open
Objective:Analyze the main legal assets harmed in cases of misappropriation of academic authorship, describing their ethical, legal and professional implications. Methodology:A conceptual and normative analysis of the rights involved was c…
View article: Oral manifestations of Monkeypox infection: clinical implications for dental diagnosis and management in emerging viral outbreaks in Brazil
Oral manifestations of Monkeypox infection: clinical implications for dental diagnosis and management in emerging viral outbreaks in Brazil Open
Introduction: The reemergence of Monkeypox (Mpx) in 2022 represented a new challenge for global public health. Although previously confined to African regions, the international spread of the virus highlighted the need for a multidisciplin…
View article: Three-dimensional topological defects and quasi-long-range order in biological liquid crystals
Three-dimensional topological defects and quasi-long-range order in biological liquid crystals Open
Active nematic liquid crystals are the main structural phase of gliomas, promoting collective migration and aggression. We establish the existence of nematic order and topological defect lines and loops in 3D in vivo mouse and human glioma…
View article: Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib
Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib Open
Isocitrate dehydrogenase (IDH)-mutant gliomas have distinctive metabolic and biological traits that potentially render them susceptible to targeted treatments. Here, by conducting a high-throughput drug screen, we pinpointed a specific vul…
View article: Oncogenic IDH1 <sup>mut</sup> drives robust loss of histone acetylation and increases chromatin heterogeneity
Oncogenic IDH1 <sup>mut</sup> drives robust loss of histone acetylation and increases chromatin heterogeneity Open
Malignant gliomas are heterogeneous tumors, mostly incurable, arising in the central nervous system (CNS) driven by genetic, epigenetic, and metabolic aberrations. Mutations in isocitrate dehydrogenase (IDH1/2 mut ) enzymes are predominant…
View article: Inhibition of H3K27M-enhanced ATM signaling increases radiation efficacy in diffuse midline glioma
Inhibition of H3K27M-enhanced ATM signaling increases radiation efficacy in diffuse midline glioma Open
H3K27-altered diffuse midline glioma (DMG) is an aggressive and treatment-resistant form of pediatric high-grade glioma (pHGG). The disease is defined by point mutations in histone H3 that convert lysine 27 to methionine (termed H3K27M), r…
View article: TMIC-50. IMPACT OF ZOTIRACICLIB ON GLIOMA TUMOR MICROENVIRONMENT
TMIC-50. IMPACT OF ZOTIRACICLIB ON GLIOMA TUMOR MICROENVIRONMENT Open
BACKGROUND Zotiraciclib, an orally administered multi-kinase inhibitor, has shown anti-glioma effect via suppression of transcriptional process and mitochondrial function. Here, we investigate the impact of zotiraciclib on the glioma immun…
View article: TMIC-62. INVESTIGATING THE ROLE OF OSTEOPONTIN IN RADIORESISTANCE OF H3.3-G34R PEDIATRIC HIGH-GRADE GLIOMA
TMIC-62. INVESTIGATING THE ROLE OF OSTEOPONTIN IN RADIORESISTANCE OF H3.3-G34R PEDIATRIC HIGH-GRADE GLIOMA Open
Pediatric high-grade gliomas (pHGGs) are currently the leading cause of cancer-related deaths in children. Around 15% of pHGGs harbor a glycine to arginine (G34R) mutation in histone H3.3. Gliomas in general, including H3.3-G34R gliomas, c…
View article: EXTH-11. PEDIATRIC GLIOMA IMMUNE PROFILING IDENTIFIES TIM3 AS A THERAPEUTIC TARGET IN BRAF-FUSION PILOCYTIC ASTROCYTOMA
EXTH-11. PEDIATRIC GLIOMA IMMUNE PROFILING IDENTIFIES TIM3 AS A THERAPEUTIC TARGET IN BRAF-FUSION PILOCYTIC ASTROCYTOMA Open
Despite being the leading cause of childhood mortality, pediatric gliomas have been relatively understudied. Repurposing of adult brain tumor immunotherapies in pediatric patients has not been successful, highlighting the need for pediatri…
View article: TMIC-79. IDH1-R132H REWIRES AUTOPHAGY IN THE GLIOMA MICROENVIRONMENT TO FACILITATE TUMOR PROGRESSION AND RESPONSE TO RADIATION
TMIC-79. IDH1-R132H REWIRES AUTOPHAGY IN THE GLIOMA MICROENVIRONMENT TO FACILITATE TUMOR PROGRESSION AND RESPONSE TO RADIATION Open
Gliomas are primary brain tumors with a poor prognosis. IDH1R132H exhibits a gain of function mutation leading to 2-hydroxyglutarate (2HG) production. We previously demonstrated, 2-HG mediated epigenetic rewiring is associated with better …
View article: CNSC-18. A SCOPING REVIEW OF HISTONE 3.3 G34R/V HIGH-GRADE GLIOMA: EPIGENETIC AND MOLECULAR PROFILES, CLINICOPATHOLOGY, AND TREATMENT AVENUES
CNSC-18. A SCOPING REVIEW OF HISTONE 3.3 G34R/V HIGH-GRADE GLIOMA: EPIGENETIC AND MOLECULAR PROFILES, CLINICOPATHOLOGY, AND TREATMENT AVENUES Open
Survival of pediatric and young adults with malignant glioma remains poor despite progress in treatment. This is especially true for histone 3.3 G34R/V (H3.3G34R/V) mutated gliomas, which often present in adolescent and young adult patient…
View article: TMIC-06. TUMOR ASSOCIATED MACROPHAGES DRIVE TUMOR PROGRESSION AND ARE TRANSCRIPTIONALLY SHAPED BY HISTONE MUTATIONS IN DIFFUSE MIDLINE GLIOMA
TMIC-06. TUMOR ASSOCIATED MACROPHAGES DRIVE TUMOR PROGRESSION AND ARE TRANSCRIPTIONALLY SHAPED BY HISTONE MUTATIONS IN DIFFUSE MIDLINE GLIOMA Open
Little progress has been made to delineate the inflammatory microenvironment in pediatric high-grade glioma (pHGG) and diffuse midline glioma (DMG). We utilize molecularly defined human samples and immunocompetent mouse models to study how…
View article: Income transfer and COVID-19 pandemic in Brazil: wrong and right at the same time
Income transfer and COVID-19 pandemic in Brazil: wrong and right at the same time Open
To alleviate the effects of socioeconomic inequalities and of the fall in economic activity on vulnerable populations during the COVID-19 pandemic, many countries have implemented or expanded income distribution programs. Brazil, amid the …
View article: P02.24.B THE IMPACT OF THE IDH1 R132H MUTATION ON MMP2 METHYLATION, EXPRESSION AND INVASION IN EXPERIMENTAL GLIOMAS AND HUMAN GBMS
P02.24.B THE IMPACT OF THE IDH1 R132H MUTATION ON MMP2 METHYLATION, EXPRESSION AND INVASION IN EXPERIMENTAL GLIOMAS AND HUMAN GBMS Open
BACKGROUND Glioblastoma (GBM) is a highly diffusive tumor which restricts the efficacy of surgical resection and facilitates tumor recurrence. Matrix metalloproteinase 2 (MMP2) is the extracellular matrix protease that is activated by MMP1…
View article: CD200 depletion in glioma enhances antitumor immunity and induces tumor rejection
CD200 depletion in glioma enhances antitumor immunity and induces tumor rejection Open
High-grade gliomas are a major health challenge with poor prognosis and high morbidity. Immune-checkpoint inhibitors (ICI) have emerged as promising therapeutic options for several malignancies yet show little efficacy against central nerv…
View article: Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma
Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma Open
Despite being the leading cause of cancer-related childhood mortality, pediatric gliomas have been relatively understudied, and the repurposing of immunotherapies has not been successful. Whole-transcriptome sequencing, single-cell sequenc…
View article: Risk Factors for Breast Cancer in Third-Year Medical Students in NOVA Medical School
Risk Factors for Breast Cancer in Third-Year Medical Students in NOVA Medical School Open
Comprehending the complexities of breast cancer, including its risk factors, methods for early detection, and treatment alternatives, is vital for effectively combating the illness and enhancing both survival rates and the quality of life …
View article: Spatiotemporal Insights into Glioma Oncostream Dynamics: Unraveling Formation, Stability, and Disassembly Pathways (Adv. Sci. 18/2024)
Spatiotemporal Insights into Glioma Oncostream Dynamics: Unraveling Formation, Stability, and Disassembly Pathways (Adv. Sci. 18/2024) Open
Unraveling the Dynamics of Brain Tumor Invasion In article number 2309796, Pedro R. Lowenstein and co‐workers present a comprehensive study on the behavior of glioma oncostreams, focusing on their formation, stability, and disassembly in v…
View article: Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma Open
Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M). DMG-H3K2…
View article: Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance Open
Supplementary Figures and Figure Legends
View article: Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance Open
Table S2. Liquid Chromatography and Mass Spectrometry Measurement of 2-hydroxyglutarate in the Conditioned Media of mIDH1 GCCs untreated, treated with vehicle (DMSO), or mIDH1 inhibitor (AGI-5198 or DS1001b)
View article: Supplementary Methods S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Supplementary Methods S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance Open
Supplementary Methods
View article: Data from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Data from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance Open
Purpose:Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to…
View article: Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance Open
Table S2. Liquid Chromatography and Mass Spectrometry Measurement of 2-hydroxyglutarate in the Conditioned Media of mIDH1 GCCs untreated, treated with vehicle (DMSO), or mIDH1 inhibitor (AGI-5198 or DS1001b)
View article: Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance Open
Supplementary Figures and Figure Legends