Yongjie Zhang
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View article: DDPM-Polycube: a denoising diffusion probabilistic model for polycube-based hexahedral mesh generation and volumetric spline construction
DDPM-Polycube: a denoising diffusion probabilistic model for polycube-based hexahedral mesh generation and volumetric spline construction Open
In this paper, we propose DDPM-Polycube, a generative polycube method based on denoising diffusion probabilistic models (DDPM) for generating hexahedral (hex) meshes and constructing volumetric splines. Unlike DL-Polycube methods that depe…
View article: A-325 The positive interference of lipidemia on Limulus amoebocyte lysate (LAL) testing in the presence of (1,3)-ß-glucan (BDG) in serum could be eliminated by the Dextran-X method
A-325 The positive interference of lipidemia on Limulus amoebocyte lysate (LAL) testing in the presence of (1,3)-ß-glucan (BDG) in serum could be eliminated by the Dextran-X method Open
Background Limulus amoebocyte lysate (LAL) is widely used in vitro diagnostic assay that can be used as an adjunct test for the diagnosis of invasive fungal infection. This assay was established using a kinetic photometric method. A key as…
View article: Artificial intelligence-based digital pathology using H&E-stained whole slide images in immuno-oncology: from immune biomarker detection to immunotherapy response prediction
Artificial intelligence-based digital pathology using H&E-stained whole slide images in immuno-oncology: from immune biomarker detection to immunotherapy response prediction Open
Immuno-oncology and the advent of immunotherapies, in particular immune checkpoint inhibitors (ICIs), have fundamentally altered the way we treat cancer. Yet only a small subset of patients actually responds to ICIs, and many face signific…
View article: Global burden and trends of high BMI-attributable chronic kidney disease: a comprehensive analysis from 1990 to 2021 and projections to 2035
Global burden and trends of high BMI-attributable chronic kidney disease: a comprehensive analysis from 1990 to 2021 and projections to 2035 Open
Background High body mass index (BMI) is a major modifiable risk factor for chronic kidney disease (CKD), significantly contributing to its global burden. This study aimed to systematically evaluate the global burden of CKD attributable to…
View article: Frenet–Serret Frame-Based Decomposition for Part Segmentation of 3-D Curvilinear Structures
Frenet–Serret Frame-Based Decomposition for Part Segmentation of 3-D Curvilinear Structures Open
Accurate segmentation of anatomical substructures within 3D curvilinear structures in medical imaging remains challenging due to their complex geometry and the scarcity of diverse, large-scale datasets for algorithm development and evaluat…
View article: GALDS: A Graph-Autoencoder-based Latent Dynamics Surrogate model to predict neurite material transport
GALDS: A Graph-Autoencoder-based Latent Dynamics Surrogate model to predict neurite material transport Open
Neurons exhibit intricate geometries within their neurite networks, which play a crucial role in processes such as signaling and nutrient transport. Accurate simulation of material transport in the networks is essential for understanding t…
View article: Optimal Horseshoe Crab Blood Collection Solution That Inhibits Cellular Exocytosis and Improves Production Yield of Limulus Amoebocyte Lysate for Use in Endotoxin Tests
Optimal Horseshoe Crab Blood Collection Solution That Inhibits Cellular Exocytosis and Improves Production Yield of Limulus Amoebocyte Lysate for Use in Endotoxin Tests Open
Limulus amoebocyte lysate (LAL) assays have emerged as among the most effective approaches for detecting endotoxins and fungi in vitro since they were first tested 50 years ago. Although detailed protocols are publicly available, conventio…
View article: Large-scale survey, animal models, and computational modeling identify histological neurodegenerative biomarkers for traumatic optic neuropathy
Large-scale survey, animal models, and computational modeling identify histological neurodegenerative biomarkers for traumatic optic neuropathy Open
BACKGROUNDTraumatic optic neuropathy (TON) is a leading cause of blindness following closed traumatic brain injury, with no effective treatments available. Previous interventional clinical trials were complicated by its low prevalence, var…
View article: Biodegradation mechanisms of p-nitrophenol and microflora dynamics in fluidized bed bioreactors
Biodegradation mechanisms of p-nitrophenol and microflora dynamics in fluidized bed bioreactors Open
p -Nitrophenol (PNP), a member of the nitroaromatic family, is widely used in the production of pesticides, dyes, pharmaceuticals, and petroleum products. As a toxic compound, PNP is highly resistance to degradation, posing a significant c…
View article: 3D neuron growth and neurodevelopmental disorder modeling based on truncated hierarchical B-splines with multi-level local refinements
3D neuron growth and neurodevelopmental disorder modeling based on truncated hierarchical B-splines with multi-level local refinements Open
3D neuron growth and neurodevelopmental disorders (NDDs) deterioration exhibit complex morphological transformations as neurites differentiate into axons and dendrites, forming intricate networks driven by tubulin concentrations and neurot…
View article: The yield of Limulus amoebocyte lysate (LAL), which is used for endotoxin detection and adjunct diagnosis of invasive fungal infection, was optimized with caffeine collection buffer
The yield of Limulus amoebocyte lysate (LAL), which is used for endotoxin detection and adjunct diagnosis of invasive fungal infection, was optimized with caffeine collection buffer Open
Background Limulus amoebocyte lysate (LAL) is a major component of the Fungal Infection Diagnosis Kit for the adjunct diagnosis of invasive fungal infections. During the previous bleeding season, PBS-collection buffer was found to prevent …
View article: Preparation and Performance Evaluation of High-Temperature Polymer Nano-Plugging Agents for Water-Based Drilling Fluids Systems Applicable to Unconventional Reservoirs
Preparation and Performance Evaluation of High-Temperature Polymer Nano-Plugging Agents for Water-Based Drilling Fluids Systems Applicable to Unconventional Reservoirs Open
To address the challenges of micro-fracture development in shale formations, frequent wellbore instability, and the limited plugging capability of water-based drilling fluids in unconventional reservoirs, a nano-plugging agent (NPA) was sy…
View article: Multistep prediction for egg prices: An efficient sequence-to-sequence network
Multistep prediction for egg prices: An efficient sequence-to-sequence network Open
Egg price has the characteristics of non-stationary, non-linear, and high volatility, which is more difficult to predict accurately. In this paper, we comprehensively consider the multiple factors affecting egg prices and construct a seque…
View article: High-throughput digital twin framework for predicting neurite deterioration using MetaFormer attention
High-throughput digital twin framework for predicting neurite deterioration using MetaFormer attention Open
Neurodevelopmental disorders (NDDs) cover a variety of conditions, including autism spectrum disorder, attention-deficit/hyperactivity disorder, and epilepsy, which impair the central and peripheral nervous systems. Their high comorbidity …