G. E. Morozevich
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View article: New Nitrogen-containing Androstane Derivatives Suppressing Prostate Carcinoma Cells Proliferation
New Nitrogen-containing Androstane Derivatives Suppressing Prostate Carcinoma Cells Proliferation Open
Derivatives of 3β-hydroxyandrost-5,16-diene and 3β-hydroxyandrost-5-ene containing 2-oxazoline, 2-benzoxazole, and 2-benzimidazole substituents at C-17 position were synthesized. Docking of the synthesized compounds into the active site of…
View article: Effect of an NGR Peptide on the Efficacy of the Doxorubicin Phospholipid Delivery System
Effect of an NGR Peptide on the Efficacy of the Doxorubicin Phospholipid Delivery System Open
This study is a continuation of an investigation into the effect of a targeted component, a peptide with an NGR, on the properties of the previously developed doxorubicin phospholipid delivery system. The NGR peptide has an affinity for am…
View article: Hematopoietic stimulants in the treatment and prevention of graft-versus-host disease
Hematopoietic stimulants in the treatment and prevention of graft-versus-host disease Open
Conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) are often accompanied by a period of aplasia characterized by severe neutropenia, anemia, and thrombocytopenia. Long-term antibacterial and immunosuppressive the…
View article: Implication of integrin α5β1 in senescence of SK-Mel-147 human melanoma cells
Implication of integrin α5β1 in senescence of SK-Mel-147 human melanoma cells Open
Downregulation of α5β1 integrin in the SK-Mel-147 human melanoma culture model sharply inhibits the phenotypic manifestations of tumor progression: cell proliferation and clonal activity. This was accompanied by a 2-3-fold increase in the …
View article: The effect of renalase-derived peptides on viability of HepG₂ and PC3 cells
The effect of renalase-derived peptides on viability of HepG₂ and PC3 cells Open
Renalase (RNLS) is a recently discovered protein, which plays different roles inside and outside cells. Intracellular RNLS is a FAD-dependent oxidoreductase (EC 1.6.3.5), while extracellular RNLS lacks its N-terminal peptide, FAD cofactor,…
View article: Erratum to: Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome
Erratum to: Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome Open
An Erratum to this paper has been published: https://doi.org/10.1134/S1068162022340015
View article: Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome
Prospects for the Use of Marine Sulfated Fucose-Rich Polysaccharides in Treatment and Prevention of COVID-19 and Post-COVID-19 Syndrome Open
Symptoms of the new coronavirus infection that appeared in 2019 (COVID-19) range from low fever and fatigue to acute pneumonia and multiple organ failure. The clinical picture of COVID-19 is heterogeneous and involves most physiological sy…
View article: Chlorin e6 Phospholipid Delivery System Featuring APN/CD13 Targeting Peptides: Cell Death Pathways, Cell Localization, In Vivo Biodistribution
Chlorin e6 Phospholipid Delivery System Featuring APN/CD13 Targeting Peptides: Cell Death Pathways, Cell Localization, In Vivo Biodistribution Open
We have previously designed a phospholipid delivery system for chlorin e6 to increase the efficacy of photodynamic therapy involving a second-generation photosensitizer. Further research into the matter led to double modification of the ob…
View article: Conjugates of Pyropheophorbide α with 17-substituted Steroidal Androgens. Synthesis, Molecular Modeling, Interaction with Some Cancer Cells
Conjugates of Pyropheophorbide α with 17-substituted Steroidal Androgens. Synthesis, Molecular Modeling, Interaction with Some Cancer Cells Open
Five new bifunctional conjugates of pyropheophorbide a with 17-substituted testosterone, dihydrotestosterone and epitestosterone differing in the length of linker ( 1–5 ) and two new complex conjugates 6 and 7 (containing three functional …
View article: Conjugates of Pyropheophorbide a with 17-Substituted Steroidal Androgens. Synthesis, Molecular Modeling, Interaction with Some Cancer Cells
Conjugates of Pyropheophorbide a with 17-Substituted Steroidal Androgens. Synthesis, Molecular Modeling, Interaction with Some Cancer Cells Open
Five new bifunctional conjugates of pyropheophorbide a with 17-substituted testosterone, dihydrotestosterone and epitestosterone differing in the length of linker (1 � 5) and two new complex conjugates 6 and 7 (containing three functional …
View article: Chondroitin Sulfate and Fucosylated Chondroitin Sulfate as Stimulators of Hematopoiesis in Cyclophosphamide-Induced Mice
Chondroitin Sulfate and Fucosylated Chondroitin Sulfate as Stimulators of Hematopoiesis in Cyclophosphamide-Induced Mice Open
The immunosuppression and inhibition of hematopoiesis are considered to be reasons for the development of complications after intensive chemotherapy and allogeneic hematopoietic stem cell transplantation. Chondroitin sulfate (CS), isolated…
View article: Composite phospholipid-gold nanoparticles with targeted fragment for tumor imaging
Composite phospholipid-gold nanoparticles with targeted fragment for tumor imaging Open
Gold nanoparticles and their conjugates have significant potential in the field of diagnosis of various diseases due to their SPR, which enhances light scattering and absorption. Conjugates of gold nanoparticles with various ligands can be…
View article: Implication of integrin α2β1 in senescence of SK-Mel-147 human melanoma cells
Implication of integrin α2β1 in senescence of SK-Mel-147 human melanoma cells Open
This investigation addressed the impact of integrin-initiated signaling pathways on senescence of tumor cells. In a model of human SK-Mel-147 melanoma cells, the silencing of integrin α2β1 strongly reduced cell proliferation and enhanced t…
View article: Implication of integrins α3β1 and α5β1 in invasion and anoikis of SK-Mel-147 human melanoma cells: non-canonical functions of protein kinase Akt
Implication of integrins α3β1 and α5β1 in invasion and anoikis of SK-Mel-147 human melanoma cells: non-canonical functions of protein kinase Akt Open
Downregulation of integrins α3β1 and α5β1 strongly decreased cell colony formation and in vitro invasion and markedly enhanced anoikis in SK-Mel-147 human melanoma cells. These modifications were accompanied by a marked increase in the lev…
View article: Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles
Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles Open
Doxorubicin is one of the widely known and frequently used chemotherapy drugs for the treatment of various types of cancer, the use of which is difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed to…
View article: Implication of integrin α2β1 in anoikis of SK-Mel-147 human melanoma cells: a non-canonical function of Akt protein kinase
Implication of integrin α2β1 in anoikis of SK-Mel-147 human melanoma cells: a non-canonical function of Akt protein kinase Open
Suppression of anoikis, a kind of apoptosis caused by disruption of contacts between cell and extracellular matrix, is an important prerequisite for cancer cell metastasis. In this communication, we demonstrate that shRNA-mediated depletio…
View article: Trifunctional (Pyropheophorbide a – Steroid – Hexadecyl Chain) Conjugates: Synthesis, Solubilization, Interaction with Cultured Cells
Trifunctional (Pyropheophorbide a – Steroid – Hexadecyl Chain) Conjugates: Synthesis, Solubilization, Interaction with Cultured Cells Open
Two novel complex conjugates (containing three functional units: pyropheophorbide a, 17α-substituted testosterone, and lipophylic hexadecyl chain, connected with L-lysine joining block) were synthesized.The scheme consisted of condensation…
View article: Photosensitizer Chlorin e6 Internalization into Tumor Cells in Phospholipid Nanoparticles Conjugated with Peptide Containing the NGR Sequence
Photosensitizer Chlorin e6 Internalization into Tumor Cells in Phospholipid Nanoparticles Conjugated with Peptide Containing the NGR Sequence Open
The possibility of increased internalization of the photosensitizer chlorin e6 in tumor cells was investigatedusing soy phosphatidylcholine nanoparticles 20-30 nm with or without attached peptide containing Asn-Gly-Arg (NGR) motif was stud…
View article: Conjugates of Pyropheophorbide a with Androgen Receptor Ligands
Conjugates of Pyropheophorbide a with Androgen Receptor Ligands Open
Two new conjugates of pyropheophorbide a with testosterone and dihydrotestosterone: 17 3 [2-(17β-hydroxy-3-oxopregn-4-en-21-oylamido)ethylamido]pyropheophorbide a (10) and 17 3 [2-(17β-hydroxy-3-oxopregnan-21-oylamido)ethylamido]pyropheoph…