Steffen U. Eisenhardt
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Impact of surgical margins on recurrence after resection of atypical lipomatous tumors: A single-center retrospective analysis Open
Marginal resection of atypical lipomatous tumors offers an acceptable local recurrence rate while allowing the preservation of critical structures and function. Regular postoperative surveillance enables early identification of tumor recur…
View article: Differentiation of acute versus chronic skin rejection in a rodent model of vascularized composite allotransplantation
Differentiation of acute versus chronic skin rejection in a rodent model of vascularized composite allotransplantation Open
Background Vascularized composite allografts (VCA) have evolved to be a potential option in complex reconstructive surgery. However, managing acute and chronic allograft rejection remains challenging. This study underlines differences betw…
View article: C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway
C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway Open
Introduction T cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection. Monomeric CRP…
View article: Intratumoral heterogeneity of cancer driver genomic alterations in myxoid liposarcomas
Intratumoral heterogeneity of cancer driver genomic alterations in myxoid liposarcomas Open
Background Myxoid liposarcomas (MLS) are rare malignant mesenchymal tumors characterized by specific translocations t(12;16) and t(12;22) with limited additional driver mutations, most notably in PIK3CA and the TERT promoter. PIK3CA is con…
View article: C-reactive protein: the nexus between inflammation and protein misfolding diseases
C-reactive protein: the nexus between inflammation and protein misfolding diseases Open
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable …
P-383 Number of mature oocytes, time and cost-effectiveness of different ovarian stimulation protocols and strategies in relation to AMH concentration in secondary fertility preservation in women Open
Study question Which stimulation protocols and stimulation strategies are most time and cost effective for secondary fertility preservation after cancer treatment in women with reduced AMH concentration? Summary answer If AMH concentration…
View article: Human Fcγ-receptors selectively respond to C-reactive protein isoforms
Human Fcγ-receptors selectively respond to C-reactive protein isoforms Open
Introduction The pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells…
View article: Human Fcγ-receptors selectively respond to C-reactive protein (CRP) isoforms
Human Fcγ-receptors selectively respond to C-reactive protein (CRP) isoforms Open
The pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ-rece…
Artificial Intelligence in Facial Palsy Treatment: A Systematic Review and Recommendations Open
Background: Artificial intelligence (AI) is rapidly advancing and increasingly applied in facial palsy research. However, there is no comprehensive review to guide surgeons on AI-based facial assessment tools. Although photographic standar…
Microsurgical versus complex physical decongestive therapy for chronic breast cancer-related lymphoedema Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of microsurgery versus complex physical decongestive therapy in people with chronic breast cancer-related lymphoedema.
View article: The LYMPH trial: comparing microsurgical with conservative treatment for chronic breast cancer-associated lymphoedema – study protocol of a pragmatic randomised international multicentre superiority trial
The LYMPH trial: comparing microsurgical with conservative treatment for chronic breast cancer-associated lymphoedema – study protocol of a pragmatic randomised international multicentre superiority trial Open
Introduction Up to one-fifth of breast cancer survivors will develop chronic breast cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard of treatment. However, it is mainly symptomati…
Improved Quantification of Circulating Tumor <span>DNA</span> in Translocation‐Associated Myxoid Liposarcoma by Simultaneous Detection of Breakpoints and Single Nucleotide Variants Open
Background Myxoid liposarcomas (MLS) can exhibit a disseminated metastatic pattern, necessitating extensive diagnostics during follow‐up. With no tumor markers available, early diagnosis of recurrences and tumor monitoring is difficult. Th…
View article: Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation
Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation Open
BACKGROUND: CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammat…
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets Open
The differential activation of recipient-derived monocytes by CRP exacerbates the innate immune response and accelerates clinical allograft rejection. Thus, therapeutic targeting of CRP represents a novel and promising strategy for prevent…
P-597 Pain intensity of oocyte retrieval of low and moderate number of oocytes is only mild, questioning the need of anesthesia and analgesia Open
Study question What is the pain intensity of oocyte retrieval (oocyte pick-up, OPU) without anesthesia and analgesia in women with low or medium number of follicles? Summary answer Pain intensity is only mild and is only slightly different…
View article: The LYMPH Trial - Comparing Microsurgical with Conservative Treatment of Chronic Breast Cancer Associated Lymphedema: Study Protocol of a Pragmatic Randomized International Multicentre Superiority Trial
The LYMPH Trial - Comparing Microsurgical with Conservative Treatment of Chronic Breast Cancer Associated Lymphedema: Study Protocol of a Pragmatic Randomized International Multicentre Superiority Trial Open
Introduction Up to one fifth of breast cancer survivors will develop chronic breast cancer-related lymphedema (BCRL). To date complex physical decongestion therapy (CDT) is the gold standard of treatment. However, it is mainly symptomatic …
View article: Non-invasive monitoring of neoadjuvant radiation therapy response in soft tissue sarcomas by multiparametric MRI and quantification of circulating tumor DNA—A study protocol
Non-invasive monitoring of neoadjuvant radiation therapy response in soft tissue sarcomas by multiparametric MRI and quantification of circulating tumor DNA—A study protocol Open
Background Wide resection remains the cornerstone of localized soft-tissue sarcomas (STS) treatment. Neoadjuvant radiation therapy (NRT) may decrease the risk of local recurrences; however, its effectiveness for different histological STS …
Special Issue: Evidence-Based Diagnosis and Management of Facial Nerve Disorders Open
Although there has been a rapid increase in the number of new publications and studies in relation to the diagnostics, impacts and rehabilitation methods of facial nerve disorders, a general structure in evidence-based medicine is still di…
The esthetic outcome of recipient sites of gracilis muscle flaps versus anterolateral thigh flaps: A retrospective study Open
Background Anterolateral thigh (ALT) and gracilis muscle flaps have been described as comparable reconstructive options regarding maximal flap dimension and indications. However, split‐thickness skin‐grafted muscle flaps are generally beli…
Evidence-based Considerations on Donor Nerve Selection and Ideal Muscle Weight in Long-standing Facial Paralysis – The Freiburg Algorithm Open
Introduction: Free functional muscle transfer (FMT) is the standard for smile reconstruction in long-standing facial paralysis. Using the contralateral NVII for innervation of the transferred muscle frequently produces satisfying results. …
Non-invasive Monitoring of Soft-tissue Sarcoma Response to Neoadjuvant Radiotherapy by Quantification of Circulating Tumor DNA (ctDNA) and Multiparametric MRI (mpMRI) Open
Introduction: Soft-tissue sarcomas (STS) are a heterogenous group of rare, yet malignant tumors. Wide resection remains the cornerstone of treatment for localized STS. Current S3 guidelines recommend neoadjuvant radiotherapy for primary, h…
C-Reactive Protein Aggravates Acute Allograft Rejection via Subset-Specific Monocyte Activation Visualized in a VCA Model Open
Introduction: The impact of the innate immune response on acute and chronic allograft rejection is poorly understood. We have recently identified a molecular mechanism that leads to a conformational change within the structure of C-reactiv…
Multiparametric magnetic resonance imaging for radiation therapy response monitoring in soft tissue sarcomas: a histology and MRI co-registration algorithm Open
Rationale: To establish a spatially exact co-registration procedure between in vivo multiparametric magnetic resonance imaging (mpMRI) and (immuno)histopathology of soft tissue sarcomas (STS) to identify imaging parameters that reflect rad…
View article: A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein Open
C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relat…
C-reactive protein, immunothrombosis and venous thromboembolism Open
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation. There is now increasing evidence that CRP is not only a marker…
Individualized Mini-Panel Sequencing of ctDNA Allows Tumor Monitoring in Complex Karyotype Sarcomas Open
Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin with high mortality. After curative resection, about one third of patients suffer from distant metastases. Tumor follow-up only covers a portion of recurrences and is associa…