Fei Liu
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View article: Auranofin attenuates TOPBP1-mediated ATR replication stress response and improves chemotherapeutic response in breast tumor models
Auranofin attenuates TOPBP1-mediated ATR replication stress response and improves chemotherapeutic response in breast tumor models Open
Genome instability is most commonly caused by replication stress, which also renders cancer cells extremely vulnerable once their response to replication stress is impeded. Topoisomerase II binding protein 1 (TOPBP1), an allosteric activat…
View article: Development and Validation of a Prognostic Model for Lung Cancer Based on Machine Learning and Immune Microenvironment Analysis
Development and Validation of a Prognostic Model for Lung Cancer Based on Machine Learning and Immune Microenvironment Analysis Open
Lung cancer prognosis varies significantly among patients, highlighting the need for accurate prediction tools. Emerging evidence suggests that the immune microenvironment plays a crucial role in lung cancer progression and treatment respo…
View article: Investigating Novel Biomarkers in Endometrial Cancer: A Study on RT-qPCR and Immunohistochemistry
Investigating Novel Biomarkers in Endometrial Cancer: A Study on RT-qPCR and Immunohistochemistry Open
This study aimed to investigate the expression patterns of HOXB9, DLX5, NGR1, and GATA6 in endometrial cancer tissues compared to adjacent non-cancerous tissues. Using RT-qPCR and immunohistochemistry, the researchers found significant upr…
View article: Hotspots and Frontiers in Arrhythmias During Pregnancy: A Bibliometric Analysis
Hotspots and Frontiers in Arrhythmias During Pregnancy: A Bibliometric Analysis Open
This bibliometric study presents a thorough overview of international research on arrhythmias in pregnant women. It identifies key contributors, influential institutions, and developing research topics, offering potential insights for opti…
View article: Validity of four low-cost smartwatches in estimating energy expenditure during cycling in Chinese untrained women
Validity of four low-cost smartwatches in estimating energy expenditure during cycling in Chinese untrained women Open
Wrist-worn activity monitors, such as smartwatches, are frequently used to monitor energy expenditure (EE) of physical activity, but there is a high degree of heterogeneity in their accuracy. The purpose of this study was to evaluate the v…
View article: Analysis of the correlation between EAT thickness and prognosis in patients with heart failure with preserved ejection fraction
Analysis of the correlation between EAT thickness and prognosis in patients with heart failure with preserved ejection fraction Open
Purpose To explore the correlation between epicardial adipose tissue (EAT) thickness and prognosis in patients with heart failure with preserved ejection fraction. Method A total of 156 patients diagnosed with heart failure with preserved …
View article: Multimodal LLM-assisted Evolutionary Search for Programmatic Control Policies
Multimodal LLM-assisted Evolutionary Search for Programmatic Control Policies Open
Deep reinforcement learning has achieved impressive success in control tasks. However, its policies, represented as opaque neural networks, are often difficult for humans to understand, verify, and debug, which undermines trust and hinders…
View article: Research trends and topics on sepsis immunosuppression: a bibliometric and visual analysis of global research from 2004 to 2024
Research trends and topics on sepsis immunosuppression: a bibliometric and visual analysis of global research from 2004 to 2024 Open
Background Sepsis, a condition characterized by critical organ impairment resulting from dysregulated response to infection, remains a leading cause of mortality globally. Immunosuppression significantly dictates the clinical trajectory an…
View article: Meta-analysis of the incidence and risk factors of postoperative delirium in organ transplant patients
Meta-analysis of the incidence and risk factors of postoperative delirium in organ transplant patients Open
BACKGROUND Postoperative delirium (POD) is a concerning complication of organ transplantation. With organ transplantation offering hope to patients with end-stage organ disease, understanding the incidence and risk factors of POD is crucia…
View article: Gut microbiome dysbiosis accelerates osteoarthritis progression by inducing IFP-SM inflammation in “double-hit” mice
Gut microbiome dysbiosis accelerates osteoarthritis progression by inducing IFP-SM inflammation in “double-hit” mice Open
These findings collectively underscore the critical role of GMB dysbiosis in modulating intestinal permeability, systemic inflammation, and OA pathogenesis. The protective effects of Bacteroidota and the B/F ratio, as well as the detriment…
View article: Comparison of two portable metabolic systems for measuring energy expenditure at rest and during exercise in untrained women
Comparison of two portable metabolic systems for measuring energy expenditure at rest and during exercise in untrained women Open
Purpose Portable metabolic systems are used as the “gold standard” for measuring energy expenditure (EE) in the development and validation of wearable devices. This study aimed to compare EE measurements obtained using the COSMED K5 (K5) a…
View article: C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients
C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients Open
Atypical hemolytic uremic syndrome (aHUS) is a rare and severe thrombotic microangiopathy caused by genetic or acquired abnormalities leading to activation of the complement alternative pathway on cell surfaces. This process leads to endot…
View article: Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19
Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19 Open
Background: Chronic kidney disease (CKD) patients with coronavirus disease 2019 (COVID-19) are at significant risk of death. However, clinical identification of high-risk individuals remains suboptimal despite the recognition of many patho…
View article: KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification
KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification Open
Vascular calcification (VC) is recognized as an independent predictor of cardiovascular events. Although estrogen replacement is a controversial treatment due to its potential carcinogenic effects, it was considered a protective treatment …
View article: Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome
Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome Open
Importance Both tacrolimus (TAC) and mycophenolate mofetil (MMF) are recommended for children with frequently relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS). However, their comparative effectiveness and …
View article: The efficacy and safety of rituximab monotherapy in the new onset pediatric idiopathic nephrotic syndrome: a randomized controlled clinical trial
The efficacy and safety of rituximab monotherapy in the new onset pediatric idiopathic nephrotic syndrome: a randomized controlled clinical trial Open
Although the CR rate of children with idiopathic NS treated with RTX alone is significantly lower, the relapse rate among responders to RTX is also lower than that of the GC treatment.
View article: Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies
Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies Open
The complement system is an essential part of innate immunity, and dysregulated complement is an underlying driver in many inflammatory and autoimmune diseases. Currently approved complement-focused therapeutics rely on systemic blockade o…