Giuseppe Foti
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View article: Effect of varying driving pressure and respiratory rate on ventilator‐induced lung injury in healthy and injured lungs: An experimental animal study
Effect of varying driving pressure and respiratory rate on ventilator‐induced lung injury in healthy and injured lungs: An experimental animal study Open
Ventilator‐induced lung injury (VILI) is a major complication of mechanical ventilation. A combined index of driving pressure (DP) and respiratory rate (RR), expressed as 4DP+RR, has been proposed to predict VILI risk. We investigated whet…
View article: Personalized ventilation guided by electrical impedance tomography with increased <scp>PEEP</scp> improves ventilation‐perfusion matching in asymmetrical airway closure and contralateral pulmonary embolism during veno‐venous extracorporeal membrane oxygenation: A case report
Personalized ventilation guided by electrical impedance tomography with increased <span>PEEP</span> improves ventilation‐perfusion matching in asymmetrical airway closure and contralateral pulmonary embolism during veno‐venous extracorporeal membrane oxygenation: A case report Open
We report the case of a 54‐year‐old man with right‐lung pneumonia and contralateral pulmonary embolism (PE) conditioning severe refractory hypoxemia requiring veno‐venous extracorporeal membrane oxygenation. Electrical impedance tomography…
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Cover Image Open
The cover image is based on the article Personalized ventilation guided by electrical impedance tomography with increased PEEP improves ventilation‐perfusion matching in asymmetrical airway closure and contralateral pulmonary embolism duri…
View article: Prognostic Value of Signal Abnormalities on Brain <scp>MRI</scp> in Post‐Anoxic Super‐Refractory Status Epilepticus: A Single‐Center Retrospective Study
Prognostic Value of Signal Abnormalities on Brain <span>MRI</span> in Post‐Anoxic Super‐Refractory Status Epilepticus: A Single‐Center Retrospective Study Open
Background Epileptiform activity, including status epilepticus (SE), occurs in up to one‐third of comatose survivors of cardiac arrest and may predict poor outcome. The relationship between SE and hypoxic–ischemic brain injury (HIBI) is no…
View article: Acute Intoxications Admitted to the Intensive Care Unit: A Retrospective Cohort Study
Acute Intoxications Admitted to the Intensive Care Unit: A Retrospective Cohort Study Open
Background: Acute intoxications are a critical yet underexplored area in intensive care. Poisoning ranks among the leading causes of injury‐related death, but limited data and the lack of clinical guidelines hinder prompt recognition and e…
View article: Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study
Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study Open
Postoperative delirium (POD) is often under-recognized in clinical practice. Blood-based markers could facilitate delirium detection and risk stratification. Neurofilament-Light chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) are pr…
View article: Not too much, not too little. Titrating flow rate to minimise inspiratory effort during helmet CPAP: A bench study
Not too much, not too little. Titrating flow rate to minimise inspiratory effort during helmet CPAP: A bench study Open
Helmet pressure swings below PEEP lead to additional inspiratory efforts. The HEPA filter acts as a flow resistor, generating an overpressure leading to increased respiratory effort. The continuous-flow rate should be titrated high enough …
View article: Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19
Derivation and external validation of predictive models for invasive mechanical ventilation in intensive care unit patients with COVID-19 Open
Background This study aimed to develop prognostic models for predicting the need for invasive mechanical ventilation (IMV) in intensive care unit (ICU) patients with COVID-19 and compare their performance with the Respiratory rate-OXygenat…
View article: Pressure Support Ventilation During Extracorporeal Membrane Oxygenation Support in Patients With Acute Respiratory Distress Syndrome
Pressure Support Ventilation During Extracorporeal Membrane Oxygenation Support in Patients With Acute Respiratory Distress Syndrome Open
In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed to limit the pr…
View article: Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan
Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan Open
Background Automated analysis of lung computed tomography (CT) scans may help characterize subphenotypes of acute respiratory illness. We integrated lung CT features measured via deep learning with clinical and laboratory data in spontaneo…
View article: Stratified analyses refine association between TLR7 rare variants and severe COVID-19
Stratified analyses refine association between TLR7 rare variants and severe COVID-19 Open
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence…
View article: Perioperative Care for Children With Syndromic Craniofacial Synostosis Undergoing Le Fort III Surgery: A Retrospective Cohort Study
Perioperative Care for Children With Syndromic Craniofacial Synostosis Undergoing Le Fort III Surgery: A Retrospective Cohort Study Open
Objective: To present characteristics, surgical variables, complications, and postoperative care in pediatric patients with craniofacial synostosis undergoing Le Fort III osteotomy. Background: Craniofacial synostoses are a group of geneti…
View article: Physiologic Effects of Extracorporeal Membrane Oxygenation in Patients with Severe Acute Respiratory Distress Syndrome
Physiologic Effects of Extracorporeal Membrane Oxygenation in Patients with Severe Acute Respiratory Distress Syndrome Open
Rationale: Blood flow rate affects mixed venous oxygenation (SvO2) during venovenous extracorporeal membrane oxygenation (ECMO), with possible effects on the pulmonary circulation and the right heart function. Objectives: To describe the p…
View article: Mechanical ventilation settings during weaning from venovenous extracorporeal membrane oxygenation
Mechanical ventilation settings during weaning from venovenous extracorporeal membrane oxygenation Open
Objectives: To describe clinical characteristics, mechanical ventilation strategies, and outcomes in patients with severe acute respiratory distress syndrome (ARDS) during weaning from venovenous extracorporeal membrane oxygenation (VV ECM…
View article: One-year survival and Quality of Life of first wave COVID-19 invasively ventilated patients in Lombardy, Italy
One-year survival and Quality of Life of first wave COVID-19 invasively ventilated patients in Lombardy, Italy Open
BACKGROUND: Lombardy was the epicenter of the first coronavirus disease 2019 (COVID-19) outbreak in western countries. The outbreak began in February 2020 and rapidly disseminated throughout the region. ICU beds were vastly insufficient an…
View article: The “ZEEP-PEEP test” to evaluate the response to positive end-expiratory pressure delivered by helmet: A prospective physiologic study
The “ZEEP-PEEP test” to evaluate the response to positive end-expiratory pressure delivered by helmet: A prospective physiologic study Open
Helmet CPAP improved oxygenation. This improvement was not only due to the PEEP effect, but also to the increase of the effective inspired FiO2. Performing the ZEEP-PEEP test may help to identify patients who benefit from PEEP.
View article: Successful Versus Failed Transition From Controlled Ventilation to Pressure Support Ventilation in COVID-19 Patients: A Retrospective Cohort Study
Successful Versus Failed Transition From Controlled Ventilation to Pressure Support Ventilation in COVID-19 Patients: A Retrospective Cohort Study Open
OBJECTIVES: In patients with COVID-19 respiratory failure, controlled mechanical ventilation (CMV) is often necessary during the acute phases of the disease. Weaning from CMV to pressure support ventilation (PSV) is a key objective when th…