Guillermo Gervasini
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View article: Combined concentrations and genetic variability of fibroblast growth factors predict cardiovascular risk in renal patients
Combined concentrations and genetic variability of fibroblast growth factors predict cardiovascular risk in renal patients Open
View article: Two decades of global tobacco control: time for a rethink
Two decades of global tobacco control: time for a rethink Open
Two decades after the adoption of the World Health Organization’s Framework Convention on Tobacco Control (FCTC) and the introduction of its MPOWER implementation package, global declines in smoking prevalence have slowed, casting doubt on…
View article: Long-Term Effect of Semaglutide on the Glomerular Filtration Rate Slope in High-Risk Patients with Diabetic Nephropathy: Analysis in Real-World Clinical Practice
Long-Term Effect of Semaglutide on the Glomerular Filtration Rate Slope in High-Risk Patients with Diabetic Nephropathy: Analysis in Real-World Clinical Practice Open
Background: Semaglutide, a GLP-1 receptor agonist, has shown promising nephroprotective effects in clinical trials, though real-world data on its long-term impact on renal function in high-risk diabetic nephropathy patients remain scarce. …
View article: Long-Term Effect of Semaglutide on the Glomerular Filtration Rate Slope in High-Risk Patients with Diabetic Nephropathy: Analysis in Real-World Clinical Practice
Long-Term Effect of Semaglutide on the Glomerular Filtration Rate Slope in High-Risk Patients with Diabetic Nephropathy: Analysis in Real-World Clinical Practice Open
Background: Semaglutide, a GLP-1 receptor agonist, has shown promising nephroprotective effects in clinical trials, though real-world data on its long-term impact on renal function in high-risk diabetic nephropathy patients remain scarce. …
View article: Impact of Combined Macronutrient Diet on Amino Acids and Amines Plasma Levels
Impact of Combined Macronutrient Diet on Amino Acids and Amines Plasma Levels Open
Background: Nutritional biomarkers are essential for assessing the impact of dietary interventions on health. Amino Acids (AA) serve as potential biomarkers due to their role in metabolic pathways, although the influence of combining macro…
View article: Association of genetic variation in the leptin-melanocortin system with drive for thinness in patients with eating disorders: A pilot study
Association of genetic variation in the leptin-melanocortin system with drive for thinness in patients with eating disorders: A pilot study Open
We aimed to investigate whether genetic variants in the leptin-melanocortin system involved in anorexigenic signaling influence personality dimensions and psychopathological symptoms in eating disorders (ED) patients. The population consis…
View article: Association of OPRD1 Gene Variants with Changes in Body Weight and Psychometric Indicators in Patients with Eating Disorders
Association of OPRD1 Gene Variants with Changes in Body Weight and Psychometric Indicators in Patients with Eating Disorders Open
Objectives: This study aimed to investigate whether genetic variations in the OPRD1 gene affect psychopathological symptoms and personality dimensions in eating disorders (ED) patients and/or contribute to ED risk. Methods: The study invol…
View article: Impact of Variability in the Delta Opioid Receptor (OPRD1) Gene on Body Mass Index and Psychometric Characteristics of Eating Disorders Patients
Impact of Variability in the Delta Opioid Receptor (OPRD1) Gene on Body Mass Index and Psychometric Characteristics of Eating Disorders Patients Open
Objectives: This study aimed to investigate whether genetic variations in the OPRD1 gene affect psychopathological symptoms and personality dimensions in eating disorders (ED) patients and/or contribute to ED risk. Methods: The study invol…
View article: Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease
Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease Open
This review provides insight into the role that obesity, but especially mediators of the adipose tissue, have in both renal disease and transplantation. In particular, we focus on the functions of leptin and adiponectin, inflammatory media…
View article: Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease
Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease Open
There is a pressing need for more precise biomarkers of chronic kidney disease (CKD). Plasma samples from 820 subjects [231 with CKD, 325 with end-stage kidney disease (ESKD) and 264 controls] were analyzed by liquid chromatography with ta…
View article: Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease
Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease Open
There is a pressing need for more precise biomarkers of chronic kidney disease (CKD). Plasma samples from 820 subjects [231 with CKD, 325 with end-stage kidney disease (ESKD) and 264 controls] were analyzed by LC-MS/MS to determine a metab…
View article: #5537 GENETIC VARIABILITY IN THE PROSTAGLANDIN E2 PATHWAY IS RELATED TO SALT SENTIVITY IN TREATMENT-NAïVE HYPERTENSIVE PATIENTS
#5537 GENETIC VARIABILITY IN THE PROSTAGLANDIN E2 PATHWAY IS RELATED TO SALT SENTIVITY IN TREATMENT-NAïVE HYPERTENSIVE PATIENTS Open
Background and Aims Hypertensive nephropathy is a common aging-related disorder. One of the main factors that contributes to the development of hypertension is salt intake. Based on blood pressure (BP) variation after sodium intake in an a…
View article: Recent Advances and Remaining Challenges in the Management of Diabetic Kidney Disease
Recent Advances and Remaining Challenges in the Management of Diabetic Kidney Disease Open
Diabetic kidney disease (DKD), which refers to pathologic structural and functional changes observed in the kidneys of patients with diabetes mellitus (DM), is the greatest contributor to CKD and the most common cause of end-stage kidney d…
View article: Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients
Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients Open
View article: <strong>Amino acids profiling in CKD</strong>
<strong>Amino acids profiling in CKD</strong> Open
Supplementary material and source data for manuscript
View article: Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy
Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy Open
Polymorphisms in genes determining glucose homeostasis may play a relevant role in renal parameters and CV-related outcomes of DN patients.
View article: Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk
Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk Open
Nephrosclerosis patients have a high cardiovascular (CV) risk that is very often of more concern than the renal disease itself. We aimed to determine whether variants in phospholipase-related genes, associated with atherosclerosis and CV o…
View article: Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy
Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy Open
Diabetic nephropathy (DN) has become the major cause of end-stage kidney disease and is associated to an extremely high cardiovascular (CV) risk. We screened 318 DN patients for 23 SNPs in four glucose transporters (SLC2A1, SLC2A…
View article: Glucose Homeostasis Genes Dataset
Glucose Homeostasis Genes Dataset Open
Genetic and clinical anonymous data for diabetic nephropathy patients
View article: Glucose homeostasis genes and diabetic nephropathy
Glucose homeostasis genes and diabetic nephropathy Open
Dataset containing clinical and genetic anonymous information on diabetic neprhopathy patients
View article: A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease
A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease Open
Diabetic kidney disease (DKD) has been pointed out as a prominent cause of chronic and end-stage renal disease (ESRD). There is a genetic predisposition to DKD, although clinically relevant loci are yet to be identified. We utilized a cust…
View article: Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy
Genetics Variants in the Epoxygenase Pathway of Arachidonic Metabolism Are Associated with Eicosanoids Levels and the Risk of Diabetic Nephropathy Open
Genes in the epoxygenase pathway of arachidonic acid metabolism leading to vasoactive eicosanoids, mainly 20-hydroxyeicosatetraenoic (20-HETE) and epoxyeicosatrienoic (EETs) acids, have been related to glucose-induced renal damage in precl…
View article: Variability in the antioxidant <i>MSRA</i> gene affects the psychopathology of patients with anorexia nervosa
Variability in the antioxidant <i>MSRA</i> gene affects the psychopathology of patients with anorexia nervosa Open
The objective is to determine whether variability in the MSRA gene, related to obesity and several psychiatric conditions, may be relevant for psychopathological symptoms common in Anorexia Nervosa (AN) and/or for the susceptibility to the…
View article: Genetic Variants in PGE2 Receptors Modulate the Risk of Nephrosclerosis and Clinical Outcomes in These Patients
Genetic Variants in PGE2 Receptors Modulate the Risk of Nephrosclerosis and Clinical Outcomes in These Patients Open
Prostaglandin E2 (PGE2) is a major actor mediating renal injury. We aimed to determine genetic variability in the genes coding for its receptors (PTGER1-4) and study associations with nephrosclerosis risk and clinical outcomes. We identifi…
View article: Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation
Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation Open
Introduction Leptin is a pro-inflammatory adipocytokine implicated in cardiovascular disease, insulin resistance, obesity and chronic kidney disease. Material and methods In a cohort of 236 renal transplant recipients, we aimed to determin…
View article: Plasma and urinary concentrations of arachidonic acid-derived eicosanoids are associated with diabetic kidney disease
Plasma and urinary concentrations of arachidonic acid-derived eicosanoids are associated with diabetic kidney disease Open
Preclinical studies indicate that arachidonic acid (AA)-derived eicosanoids contribute to hyperglycemia-induced kidney injury. We aimed to determine whether plasma and/or urinary levels of dihydroxyeicosatrienoic (DHETs) and 20-hydroxyeico…
View article: Phospholipases genes dataset
Phospholipases genes dataset Open
Dataset with clinical, demographic and genetic data of nephrosclerosis patients and controls
View article: Supplementary Table S1.xlsx
Supplementary Table S1.xlsx Open
Supplementary table for the article "PLASMA AND URINARY CONCENTRATIONS OF ARACHIDONIC ACID-DERIVED EICOSANOIDS ARE ASSOCIATED WITH DIABETIC KIDNEY DISEASE" in Excli J
View article: Supplementary Table S1.xlsx
Supplementary Table S1.xlsx Open
Supplementary table for the article "PLASMA AND URINARY CONCENTRATIONS OF ARACHIDONIC ACID-DERIVED EICOSANOIDS ARE ASSOCIATED WITH DIABETIC KIDNEY DISEASE" in Excli J
View article: Phospholipases genes dataset
Phospholipases genes dataset Open
Dataset with clinical, demographic and genetic data of nephrosclerosis patients and controls