Gorm Greisen
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View article: Treatment guided by cerebral oximetry in mechanically ventilated newborns: a statistical analysis plan for step one of the SafeBoosC-IIIv randomised clinical trial
Treatment guided by cerebral oximetry in mechanically ventilated newborns: a statistical analysis plan for step one of the SafeBoosC-IIIv randomised clinical trial Open
ClinicalTrials.gov NCT05907317. First submitted on 8 June 2023, https://clinicaltrials.gov/study/NCT05907317.
View article: A Family‐Centred Paediatric Delirium Bundle: A Feasibility Study
A Family‐Centred Paediatric Delirium Bundle: A Feasibility Study Open
Background Paediatric delirium (PD) is a common disorder in critically ill children. PD management, however, needs improvement. To this end, we developed a family‐centred non‐pharmacological delirium management bundle based on consensus fr…
View article: O-285 Reproductive hormones at 7-10 years of age in children born after assisted reproductive technology
O-285 Reproductive hormones at 7-10 years of age in children born after assisted reproductive technology Open
Study question Do reproductive hormones and pubertal development differ at 7-10 years of age in children conceived after frozen embryo transfer, fresh embryo transfer or natural conception? Summary answer Pubertal development, reproductive…
View article: Low Parental Participation in a Randomised Clinical Trial of Video Tutorials: A Qualitative Study
Low Parental Participation in a Randomised Clinical Trial of Video Tutorials: A Qualitative Study Open
Aim Parents calling a Danish out‐of‐hours nonurgent medical helpline were invited to a trial comparing video tutorials on managing children's acute illnesses with telephone triage by health professionals. Participants allocated to videos w…
View article: Parents’ Motivations for Calling an Out-of-Hours Helpline: Qualitative Study
Parents’ Motivations for Calling an Out-of-Hours Helpline: Qualitative Study Open
Background Young children often get sick, and although they usually do not need treatment, it can be distressing for parents and lead to a high rate of urgent health care use. As the demand for out-of-hours services grows, understanding pa…
View article: Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial
Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial Open
Objectives To compare the effect of liberal versus restrictive transfusion strategies on the proportion of time (%time) spent with intermittent hypoxaemia (IH, ie, arterial haemoglobin oxygen saturation measured by pulse oximetry (SpO 2 ) …
View article: Postnatal growth and metabolic blood biomarkers in preterm infants developing reversible retinopathy of prematurity
Postnatal growth and metabolic blood biomarkers in preterm infants developing reversible retinopathy of prematurity Open
Purpose To investigate predictive potential of growth and metabolic blood biomarkers in the development of milder, reversible retinopathy of prematurity (ROP) stages. Methods Biomarkers were obtained from blood samples collected every seco…
View article: The risk of epilepsy after neonatal seizures
The risk of epilepsy after neonatal seizures Open
Aim To estimate the cumulative risk of epilepsy after neonatal seizures and identify subpopulations at increased risk. Method This was a nationwide register‐based cohort study including all children born in Denmark between 1997 and 2018. T…
View article: Correction: The use of paracetamol during pregnancy: A qualitative study and possible strategies for a clinical trial
Correction: The use of paracetamol during pregnancy: A qualitative study and possible strategies for a clinical trial Open
[This corrects the article DOI: 10.1371/journal.pone.0271537.].
View article: Visceral and subcutaneous adipose tissue in children born after ART with frozen and fresh embryo transfers
Visceral and subcutaneous adipose tissue in children born after ART with frozen and fresh embryo transfers Open
STUDY QUESTION Is the ratio of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) comparable between children following ART and natural conception (NC)? SUMMARY ANSWER Children conceived by frozen embryo transfer (FET) had…
View article: Effects of red blood cell transfusion on cerebral hemodynamics of preterm neonates
Effects of red blood cell transfusion on cerebral hemodynamics of preterm neonates Open
The results confirm previous CW-NIRS studies, but the wide variability of BFI makes the effects of RBCT on cerebral metabolism uncertain.
View article: Cerebral oximetry monitoring versus usual care for extremely preterm infants: a detailed statistical analysis plan for the 2-year follow-up of the SafeBoosC-III randomised clinical trial
Cerebral oximetry monitoring versus usual care for extremely preterm infants: a detailed statistical analysis plan for the 2-year follow-up of the SafeBoosC-III randomised clinical trial Open
Background The SafeBoosC-III trial investigated treatment guided by cerebral oximetry monitoring for the first 72 hours after birth in extremely preterm infants and showed no effects on mortality or severe brain injury at 36 weeks’ postmen…
View article: Five‐year neurodevelopmental assessment of extremely preterm or extremely low birthweight infants: Association with school performance
Five‐year neurodevelopmental assessment of extremely preterm or extremely low birthweight infants: Association with school performance Open
Aim We investigated the associations between motor performance and IQ at 5 years of age and school difficulties and grade point averages (GPAs) at 18 years of age. Additionally, the accuracy of preschool IQ in predicting school difficultie…
View article: Increasing prevalence of cerebral palsy in children born very preterm in Denmark
Increasing prevalence of cerebral palsy in children born very preterm in Denmark Open
Aim To analyse the rising prevalence of cerebral palsy (CP) in children born preterm in Denmark. Method We included all live‐born children born preterm in Denmark from 1997 to 2013. The prevalence of CP in children born preterm was categor…
View article: P-784 Visceral and subcutaneous adipose tissue in children born after assisted reproductive technology with frozen and fresh embryo transfer
P-784 Visceral and subcutaneous adipose tissue in children born after assisted reproductive technology with frozen and fresh embryo transfer Open
Study question Is the distribution of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) comparable between children following assisted reproduction and natural conception (NC)? Summary answer Children following …
View article: If things were simple, word would have gotten around. - Can complexity science help us improve pediatric research?
If things were simple, word would have gotten around. - Can complexity science help us improve pediatric research? Open
Complexity science is a discipline which explores how complex systems behave and how we interact with them. Though it is widely implemented outside medicine, particularly in the sciences involving human behavior, but also in the natural sc…
View article: Time intervals between pumping did not affect breastmilk protein produced by mothers of preterm infants
Time intervals between pumping did not affect breastmilk protein produced by mothers of preterm infants Open
Aim Few studies investigate factors that might influence the content of expressed breastmilk. This study aims to investigate the influence of the intervals between breastmilk pumping and the time of the day on protein and fat concentration…
View article: The parent perspective on paediatric delirium and an associated care bundle: A qualitative study
The parent perspective on paediatric delirium and an associated care bundle: A qualitative study Open
Aims To explore how parents experienced their child with delirium and how parents viewed our delirium management bundle. Design We conducted a qualitative exploratory descriptive study using semi‐structured individual or dyad interviews. M…
View article: Blood pressure and lipid profiles in children born after ART with frozen embryo transfer
Blood pressure and lipid profiles in children born after ART with frozen embryo transfer Open
STUDY QUESTION Are blood pressure (BP) and lipid profiles different between children conceived after ART with frozen embryo transfer (FET), fresh embryo transfer (fresh-ET), and natural conception (NC)? SUMMARY ANSWER Girls conceived after…
View article: Cerebrovascular reactivity to carbon dioxide tension in newborns: data from combined time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy
Cerebrovascular reactivity to carbon dioxide tension in newborns: data from combined time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy Open
BabyLux device detected -induced changes in cerebral and CBF, as expected. The small statistically significant positive relationship between and variation is not considered clinically relevant and we are inclined to consider it as an ar…
View article: Video Tutorials to Empower Caregivers of Ill Children and Reduce Health Care Utilization
Video Tutorials to Empower Caregivers of Ill Children and Reduce Health Care Utilization Open
Importance Young children often fall ill, leading to concern among their caregivers and urgent contact with health care services. Objective To assess the effectiveness and safety of video tutorials to empower caregivers in caring for acute…